Protein detail

NID2

Nidogen-2 (NID-2) (Osteonidogen)

Protein symbol
NID2
UniProt ID
EVMP score
0.50
Frequency
2
Transmembrane count
Protein classification
Plasma proteinsPredicted intracellular proteinsPredicted secreted proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Nidogen-2 (NID-2) (Osteonidogen)
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function
  • Predicted secreted proteins
  • Predicted intracellular proteins
Entrez Gene Symbol
Gene Description
Nidogen 2
Chromosome
14
Position
52004809-52069059
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAdrenal medulla cellsBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

32 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmCellinkerYesNoYesNoNo
glycoproteinecmMatrisomeYesNoYesNoNo
basement_membraneecmMatrisomeYesNoYesNoNo
ligandligandtalklrYesNoYesNoNo
ligandligandconnectomeDB2020YesNoYesNoNo
ligandligandiTALKYesNoYesNoNo
ligandligandEMBRACEYesNoYesNoNo
ligandligandCellTalkDBYesNoYesNoNo
ligandligandRamilowski2015YesNoYesNoNo
ligandligandLRdbYesNoYesNoNo
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Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
B4GALNT4LYG2NID2PILRAPILRBQ14112Q76KP1Q86SG7Q9UKJ0Q9UKJ10:0:0:0:0hu.MAP2
LYG2NID2Q14112Q86SG70:0hu.MAP2
LRRTM4NID2PILRAPILRBQ14112Q86VH4Q9UKJ0Q9UKJ10:0:0:0hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry [LTQ-FT Ultra]R SequencingMass spectrometry3323849373230158129603567
Sequence, Structure & Domains

Sequences

Length
1,375
Mass
151,254
Sequence
MEGDRVAGRPVLSSLPVLLLLPLLMLRAAALHPDELFPHGESWGDQLLQEGDDESSAVVKLANPLHFYEARFSNLYVGTNGIISTQDFPRETQYVDYDFPTDFPAIAPFLADIDTSHGRGRVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSGELNTFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDLKSEGPYFSLTSTEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVPLGRSFSHATALESDYNEDNLDYYDVNEEEAEYLPGEPEEALNGHSSIDVSFQSKVDTKPLEESSTLDPHTKEGTSLGEVGGPDLKGQVEPWDERETRSPAPPEVDRDSLAPSWETPPPYPENGSIQPYPDGGPVPSEMDVPPAHPEEEIVLRSYPASGHTTPLSRGTYEVGLEDNIGSNTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTVTSTSSRDYSLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTGRK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14112-1; Sequence=Displayed; Name=2; IsoId=Q14112-2; Sequence=VSP_038779, VSP_038780
Alternative Sequence
7..59; Missing (in isoform 2); 844..892; LITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTD -> Y (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
386..403; Basic and acidic residues; 999..1014; Pro residues
Repeat
1154..1197; LDL-receptor class B 1; 1198..1240; LDL-receptor class B 2; 1241..1285; LDL-receptor class B 3; 1286..1327; LDL-receptor class B 4; 1329..1373; LDL-receptor class B 5
Domain (FT)
108..273; NIDO; 484..524; EGF-like 1; 528..758; Nidogen G2 beta-barrel; 759..800; EGF-like 2; 801..843; EGF-like 3; calcium-binding; 848..891; EGF-like 4; 892..930; EGF-like 5; calcium-binding; 937..1005; Thyroglobulin type-1 1; 1016..1084; Thyroglobulin type-1 2
Region
348..437; Disordered; 992..1016; Disordered
Clinical Relevance
Interaction Protein
ENSG00000135862
Interaction Count
1
Interaction Dataset
biogrid_bioplex