Protein detail
LRP8
Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)
Protein symbol LRP8 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins |
Basic Information
Protein Names
Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted secreted proteins
- Predicted intracellular proteins
Transmembrane
827..847; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
APOER2HSZ75190LRP-8MCI1
Gene Description
LDL receptor related protein 8
Chromosome
1
Position
53242364-53328469
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificepididymisCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmyeloid DC
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted secreted proteins
- Predicted intracellular proteins
Cellular Component
- GO:0005615 extracellular space
- GO:0005875 microtubule associated complex
- GO:0005886 plasma membrane
- GO:0005901 caveola
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0043025 neuronal cell body
- GO:0043235 receptor complex
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0098839 postsynaptic density membrane
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0004888 transmembrane signaling receptor activity
- GO:0005041 low-density lipoprotein particle receptor activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008035 high-density lipoprotein particle binding
- GO:0019894 kinesin binding
- GO:0030229 very-low-density lipoprotein particle receptor activity
- GO:0034185 apolipoprotein binding
- GO:0038024 cargo receptor activity
- GO:0038025 reelin receptor activity
- GO:0048306 calcium-dependent protein binding
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| low_density_lipoprotein | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| low_density_lipoprotein_ldl_receptor_and_ldl_receptor_related_proteins | receptor | HPMR | No | Yes | Yes | Yes | No |
| ldlr | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | No |
| extracellular | extracellular | HPMR | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | Yes | Yes | No |
| matrix_adhesion | matrix_adhesion | Cellinker | No | Yes | Yes | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRS11 | Q05519 | LRP8 | Q14114 | Yes | Yes | No | SIGNOR | SIGNOR:31269452 |
| FYN | P06241 | LRP8 | Q14114 | Yes | Yes | No | WangSIGNOR | SIGNOR:25340851 |
| MYLIP | Q8WY64 | LRP8 | Q14114 | Yes | No | Yes | SIGNOR | SIGNOR:20427281 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Grin2a-Lrp8 complex | GRIN2AGRIN2CLRP8 | Q12879Q14114Q14957 | 1:1:1 | Compleat | Compleat:HC1347 | 16102539 |
| LRP8LRPAP1 | P30533Q14114 | 0:0 | hu.MAP2 | |||
| MAP2K5MAP3K2MAP3K3MAPK7NLRP8TRAF7 | Q13163Q13164Q6Q0C0Q86W28Q99759Q9Y2U5 | 0:0:0:0:0:0 | hu.MAP2 | |||
| MAP2K5MAP3K2MAP3K3MAPK7NLRP8 | Q13163Q13164Q86W28Q99759Q9Y2U5 | 0:0:0:0:0 | hu.MAP2 | |||
| ARHGAP39LRP8 | Q14114Q9C0H5 | 0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
963
Mass
105,634
Sequence
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP
Alternative Products
Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist. No differences were observed in the pattern splicing between control and Alzheimer brains.; Name=1; Synonyms=ApoER2 922; IsoId=Q14114-1; Sequence=Displayed; Name=2; Synonyms=ApoER2 906; IsoId=Q14114-2; Sequence=VSP_010305, VSP_010307, VSP_010308; Name=3; IsoId=Q14114-3; Sequence=VSP_010308; Name=4; Synonyms=ApoER2delta4-7; IsoId=Q14114-4; Sequence=VSP_038181, VSP_010306; Name=5; IsoId=Q14114-5; Sequence=Not described
Alternative Sequence
166..295; LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP -> S (in isoform 2); 166; L -> W (in isoform 4); 167..336; Missing (in isoform 4); 737..812; APQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHY -> D (in isoform 2); 893..951; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
119..121; 339..341; 459..462; 469..472; 506..509; 516..519; 549..552; 593..596; 603..606; 625..627; 646..649; 656..658; 689..691
Helix
53..56; 62..64; 76..78; 101..103; 115..117; 342..344; 379..381; 479..481; 485..487; 680..682; 696..699
Beta Strand
59..61; 67..69; 72..75; 88..92; 98..100; 106..108; 348..352; 355..357; 359..361; 368..372; 385..393; 396..400; 405..407; 409..412; 414..416; 418..420; 423..427; 429..439; 442..458; 463..468; 473..478; 489..492; 501..505; 510..515; 520..525; 530..535; 540..548; 553..558; 560..562; 564..569; 576..579; 586..592; 597..602; 607..612; 619..622; 629..637; 640..645; 650..655; 663..666; 675..678; 692..695; 701..706; 710..714; 716..720; 731..735
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
765..777; Polar residues; 778..799; Low complexity; 800..812; Polar residues
Repeat
462..508; LDL-receptor class B 1; 509..551; LDL-receptor class B 2; 552..595; LDL-receptor class B 3; 596..639; LDL-receptor class B 4; 640..681; LDL-receptor class B 5
Domain (CC)
The cytoplasmic domain is involved in the binding of DAB1 and in the recruitment of JNK-interacting proteins. Isoforms, which lack part of the cytoplasmic domain, are unable to recruit members of the family of JNK interacting proteins (JIP) to the cytoplasmic tail (By similarity).
Domain (FT)
46..82; LDL-receptor class A 1; 85..123; LDL-receptor class A 2; 126..164; LDL-receptor class A 3; 166..202; LDL-receptor class A 4; 205..246; LDL-receptor class A 5; 258..295; LDL-receptor class A 6; 298..334; LDL-receptor class A 7; 336..375; EGF-like 1; 376..415; EGF-like 2; calcium-binding
Region
740..798; Clustered O-linked oligosaccharides; 754..815; Disordered
Protein Families
LDLR family
Sequence Similarities
Belongs to the LDLR family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000163956
Interaction Count
1
Interaction Dataset
intact_biogrid