Protein detail

LRP8

Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)

Entry name LRP8	UniProt ID Q14114	EVMP confidence score 0.38
Supporting publications (n)	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)

Protein Class (5)

Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function (4)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted secreted proteins
Predicted intracellular proteins

Transmembrane

827..847; Helical

Transmembrane Count

Ensembl

ENSG00000157193

Entrez Gene Symbol

LRP8

Gene Synonym (4)

APOER2HSZ75190LRP-8MCI1

Gene Description

LDL receptor related protein 8

Chromosome

Position

53242364-53328469

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificepididymisCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmyeloid DC

Function & Pathway6

Protein Function (4)

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted secreted proteins
Predicted intracellular proteins

Cellular Component (13)

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Molecular Function (12)

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Biological Process (3)

Reactome (7)

Mediation Categories (3)

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence69

Ligand-Receptor Signaling (60)

60 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	iTALK	No	Yes	Yes	Yes	No
receptor	receptor	Almen2009	No	Yes	Yes	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	Yes	Yes	No
receptor	receptor	EMBRACE	No	Yes	Yes	Yes	No
low_density_lipoprotein	receptor	HGNC	No	Yes	Yes	Yes	No
receptor	receptor	HGNC	No	Yes	Yes	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	Yes	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRS11	Q05519	LRP8	Q14114	Yes	Yes	No	SIGNOR	SIGNOR:31269452
FYN	P06241	LRP8	Q14114	Yes	Yes	No	WangSIGNOR	SIGNOR:25340851
MYLIP	Q8WY64	LRP8	Q14114	Yes	No	Yes	SIGNOR	SIGNOR:20427281

Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Grin2a-Lrp8 complex	GRIN2A GRIN2C LRP8	Q12879 Q14114 Q14957	1:1:1	Compleat	Compleat:HC1347	16102539
	LRP8 LRPAP1	P30533 Q14114	0:0	hu.MAP2
	MAP2K5 MAP3K2 MAP3K3 MAPK7 NLRP8 TRAF7	Q13163 Q13164 Q6Q0C0 Q86W28 Q99759 Q9Y2U5	0:0:0:0:0:0	hu.MAP2
	MAP2K5 MAP3K2 MAP3K3 MAPK7 NLRP8	Q13163 Q13164 Q86W28 Q99759 Q9Y2U5	0:0:0:0:0	hu.MAP2
	ARHGAP39 LRP8	Q14114 Q9C0H5	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Western blottingFlow cytometry	3	32384937 32795414 38321535

Sequence, Structure & Domains16

Sequences

Length

963

Mass

105,634

Sequence

MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP

Alternative Products

Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist. No differences were observed in the pattern splicing between control and Alzheimer brains.; Name=1; Synonyms=ApoER2 922; IsoId=Q14114-1; Sequence=Displayed; Name=2; Synonyms=ApoER2 906; IsoId=Q14114-2; Sequence=VSP_010305, VSP_010307, VSP_010308; Name=3; IsoId=Q14114-3; Sequence=VSP_010308; Name=4; Synonyms=ApoER2delta4-7; IsoId=Q14114-4; Sequence=VSP_038181, VSP_010306; Name=5; IsoId=Q14114-5; Sequence=Not described

Alternative Sequence

166..295; LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP -> S (in isoform 2); 166; L -> W (in isoform 4); 167..336; Missing (in isoform 4); 737..812; APQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHY -> D (in isoform 2); 893..951; Missing (in isoform 2 and isoform 3)

3D Structural Models

Turn

119..121; 339..341; 459..462; 469..472; 506..509; 516..519; 549..552; 593..596; 603..606; 625..627; 646..649; 656..658; 689..691

Helix

53..56; 62..64; 76..78; 101..103; 115..117; 342..344; 379..381; 479..481; 485..487; 680..682; 696..699

Beta Strand

59..61; 67..69; 72..75; 88..92; 98..100; 106..108; 348..352; 355..357; 359..361; 368..372; 385..393; 396..400; 405..407; 409..412; 414..416; 418..420; 423..427; 429..439; 442..458; 463..468; 473..478; 489..492; 501..505; 510..515; 520..525; 530..535; 540..548; 553..558; 560..562; 564..569; 576..579; 586..592; 597..602; 607..612; 619..622; 629..637; 640..645; 650..655; 663..666; 675..678; 692..695; 701..706; 710..714; 716..720; 731..735

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

765..777; Polar residues; 778..799; Low complexity; 800..812; Polar residues

Repeat

462..508; LDL-receptor class B 1; 509..551; LDL-receptor class B 2; 552..595; LDL-receptor class B 3; 596..639; LDL-receptor class B 4; 640..681; LDL-receptor class B 5

Domain (CC)

The cytoplasmic domain is involved in the binding of DAB1 and in the recruitment of JNK-interacting proteins. Isoforms, which lack part of the cytoplasmic domain, are unable to recruit members of the family of JNK interacting proteins (JIP) to the cytoplasmic tail (By similarity).

Domain (FT)

46..82; LDL-receptor class A 1; 85..123; LDL-receptor class A 2; 126..164; LDL-receptor class A 3; 166..202; LDL-receptor class A 4; 205..246; LDL-receptor class A 5; 258..295; LDL-receptor class A 6; 298..334; LDL-receptor class A 7; 336..375; EGF-like 1; 376..415; EGF-like 2; calcium-binding

Region

740..798; Clustered O-linked oligosaccharides; 754..815; Disordered

Protein Families

LDLR family

Sequence Similarities

Belongs to the LDLR family.

Clinical Relevance4

Antibody

HPA073031

Interaction Protein

ENSG00000163956

Interaction Count

Interaction Dataset

intact_biogrid