Protein detail
DAG1
Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]
Protein symbol DAG1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)]
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
- Transporters
- Potential drug targets
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
- Disease related genes
Transmembrane
750..775; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
156DAGA3aAGRNRDAG
Gene Description
Dystroglycan 1
Chromosome
3
Position
49468713-49535618
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificHofbauer cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of glycan/glycoprotein metabolism
- Transporters
- Potential drug targets
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
- Disease related genes
Cellular Component
- GO:0005576 extracellular region
- GO:0005604 basement membrane
- GO:0005615 extracellular space
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005788 endoplasmic reticulum lumen
- GO:0005796 Golgi lumen
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0005925 focal adhesion
- GO:0009897 external side of plasma membrane
- GO:0016010 dystrophin-associated glycoprotein complex
- GO:0016011 dystroglycan complex
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0030027 lamellipodium
- GO:0030175 filopodium
- GO:0033268 node of Ranvier
- GO:0034399 nuclear periphery
- GO:0042383 sarcolemma
- GO:0043034 costamere
- GO:0043231 intracellular membrane-bounded organelle
- GO:0044853 plasma membrane raft
- GO:0045211 postsynaptic membrane
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
- GO:0070938 contractile ring
- GO:0098684 photoreceptor ribbon synapse
- GO:0098978 glutamatergic synapse
- GO:0098982 GABA-ergic synapse
- GO:0099524 postsynaptic cytosol
Molecular Function
- GO:0001618 virus receptor activity
- GO:0002162 dystroglycan binding
- GO:0003779 actin binding
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008307 structural constituent of muscle
- GO:0015631 tubulin binding
- GO:0017166 vinculin binding
- GO:0042169 SH2 domain binding
- GO:0043236 laminin binding
- GO:0043237 laminin-1 binding
- GO:0044877 protein-containing complex binding
- GO:0051393 alpha-actinin binding
Biological Process
KEGG
Reactome
- R-hsa-8932504 dag1 core m2 glycosylations
- R-hsa-8932505 dag1 core m3 glycosylations
- R-hsa-8931838 dag1 glycosylations
- R-hsa-3906995 diseases associated with o glycosylation of proteins
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-3000178 ecm proteoglycans
- R-hsa-9619665 egr2 and sox10 mediated initiation of schwann cell myelination
- R-hsa-1474244 extracellular matrix organization
- R-hsa-9913351 formation of the dystrophin glycoprotein complex dgc
- R-hsa-9939291 matriglycan biosynthesis on dag1
- R-hsa-9675108 nervous system development
- R-hsa-3000171 non integrin membrane ecm interactions
- R-hsa-5173105 o linked glycosylation
- R-hsa-597592 post translational protein modification
- R-hsa-9010553 regulation of expression of slits and robos
- R-hsa-376176 signaling by robo receptors
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| DAG1 | SRC | P12931 | Y | 892 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDRLIMS-P_ProtMapperKEAphosphoELMSIGNOR_ProtMapper | phosphoELM:12795607ProtMapper:18982058ProtMapper:12795607KEA:12795607HPRD:12795607 |
Ligand-Receptor Signaling
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | UniProt_keyword | No | No | Yes | Yes | No |
| secreted | secreted | UniProt_location | No | No | Yes | Yes | No |
| secreted | secreted | Baccin2019 | No | No | Yes | Yes | No |
| secreted | secreted | OmniPath | No | No | Yes | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | Yes | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | Yes | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | Yes | No |
Regulatory Interaction Network
9 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:Q9UKY4_Q9Y6A1 | DAG1 | Q14118 | Yes | Yes | No | SIGNOR | SIGNOR:14699049 | |
| NRX2A | Q9P2S2 | DAG1 | Q14118 | Yes | Yes | No | CellPhoneDBCellChatDBSIGNOR | SIGNOR:22626542CellChatDB:21628410 |
| NRX2B | P58401 | DAG1 | Q14118 | Yes | Yes | No | CellPhoneDBCellChatDBSIGNOR | SIGNOR:22626542CellChatDB:21628410 |
| NRX3B | Q9HDB5 | DAG1 | Q14118 | Yes | Yes | No | CellPhoneDBSIGNOR | SIGNOR:22626542 |
| NRX3A | Q9Y4C0 | DAG1 | Q14118 | Yes | Yes | No | CellPhoneDBSIGNOR | SIGNOR:22626542 |
| NRX1A | Q9ULB1 | DAG1 | Q14118 | Yes | Yes | No | CellPhoneDBCellChatDBSIGNOR | SIGNOR:22626542CellChatDB:21628410 |
| NRX1B | P58400 | DAG1 | Q14118 | Yes | Yes | No | CellPhoneDBCellChatDBSIGNOR | SIGNOR:22626542CellChatDB:21628410 |
| ANK3 | Q12955 | DAG1 | Q14118 | Yes | Yes | No | SIGNOR | SIGNOR:19109891 |
| SRC | P12931 | DAG1 | Q14118 | Yes | Yes | Yes | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAphosphoELM_KEALit-BM-17DOMINOHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperSPIKE_LCHPRD-phos | Lit-BM-17:17474147HINT:11724572DOMINO:17474147ProtMapper:18982058phosphoELM:12795607ProtMapper:12795607SPIKE_LC:17474147Lit-BM-17:11724572SIGNOR:12795607KEA:12795607HPRD:12795607HPRD-phos:12795607 |
Protein Complex Composition
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Kir4.1-beta-dystroglycan complexwhole brain lysate | DAG1KCNJ10 | P78508Q14118 | 1:1 | Compleat | Compleat:HC3174 | 15102837 |
| DAG1LGALS9LGALS9BLGALS9CPBK | O00182Q14118Q3B8N2Q6DKI2Q96KB5 | 0:0:0:0:0 | hu.MAP2 | |||
| DAG1LGALS9LGALS9BPBK | O00182Q14118Q3B8N2Q96KB5 | 0:0:0:0 | hu.MAP | |||
| CORO7DAG1 | P57737Q14118 | 0:0 | Havugimana2012 | Havugimana2012:C_18 | ||
| DAG1DTNASNTB1 | Q13884Q14118Q9Y4J8 | 0:0:0 | KEGG-MEDICUS | |||
| DAG1 | Q14118 | 4 | PDB | PDB:8uf4 | ||
| DAG1POMGNT1 | Q14118Q8WZA1 | 2:2 | PDB | PDB:5ggp | ||
| DAG1DTNASNTG1 | Q14118Q9NSN8Q9Y4J8 | 0:0:0 | KEGG-MEDICUS |
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
895
Mass
97,441
Sequence
MRMSVGLSLLLPLSGRTFLLLLSVVMAQSHWPSEPSEAVRDWENQLEASMHSVLSDLHEAVPTVVGIPDGTAVVGRSFRVTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLEGLPLDTDKGVHYISVSATRLGANGSHIPQTSSVFSIEVYPEDHSELQSVRTASPDPGEVVSSACAADEPVTVLTVILDADLTKMTPKQRIDLLHRMRSFSEVELHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCSLNQNSVPDIHGVEAPAREGAMSAQLGYPVVGWHIANKKPPLPKRVRRQIHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTRVSEAGTTVPGQIRPTMTIPGYVEPTAVATPPTTTTKKPRVSTPKPATPSTDSTTTTTRRPTKKPRTPRPVPRVTTKVSITRLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDAWVGTYFEVKIPSDTFYDHEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLSAVDAFEIHVHRRPQGDRAPARFKAKFVGDPALVLNDIHKKIALVKKLAFAFGDRNCSTITLQNITRGSIVVEWTNNTLPLEPCPKEQIAGLSRRIAEDDGKPRPAFSNALEPDFKATSITVTGSGSCRHLQFIPVVPPRRVPSEAPPTEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGKLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSVPETTPLNQDTMGEYTPLRDEDPNAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP
3D Structural Models
Turn
112..115; 268..270
Helix
84..87; 123..125; 159..161; 199..201; 204..218; 222..224; 275..283; 285..290
Beta Strand
70..73; 78..81; 93..98; 101..103; 108..111; 116..119; 127..138; 144..157; 188..196; 225..229; 241..245; 256..265; 294..302; 372..377; 379..384
3D Structure
NMR spectroscopy (1); X-ray crystallography (7)
Domain & Motif Annotations
Compositional Bias
413..447; Low complexity; 724..735; Pro residues; 736..746; Basic and acidic residues; 832..846; Polar residues; 859..870; Pro residues
Motif
776..782; Nuclear localization signal; 889..892; PPXY motif
Domain (FT)
603..712; Peptidase S72
Region
30..408; Required for laminin recognition; 169..200; O-glycosylated at one site; 316..485; Mucin-like domain; 381..460; Disordered; 463..485; O-glycosylated at seven sites with GalNAc; 478..498; Disordered; 724..746; Disordered; 819..895; Required for interaction with CAV3; 823..895; Disordered; 880..895; Required for binding DMD and UTRN