Protein detail
DSG2
Desmoglein-2 (Cadherin family member 5) (HDGC)
Entry name DSG2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Desmoglein-2 (Cadherin family member 5) (HDGC)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Transmembrane
610..634; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CDHF5
Gene Description
Desmoglein 2
Chromosome
18
Position
31498177-31549008
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Cellular Component
- GO:0001533 cornified envelope
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0009986 cell surface
- GO:0014704 intercalated disc
- GO:0016324 apical plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0030054 cell junction
- GO:0030057 desmosome
- GO:0043231 intracellular membrane-bounded organelle
- GO:0070062 extracellular exosome
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-109581 apoptosis
- R-hsa-111465 apoptotic cleavage of cellular proteins
- R-hsa-351906 apoptotic cleavage of cell adhesion proteins
- R-hsa-75153 apoptotic execution phase
- R-hsa-6809371 formation of the cornified envelope
- R-hsa-6805567 keratinization
- R-hsa-5357801 programmed cell death
- R-hsa-9013404 rac2 gtpase cycle
- R-hsa-9013423 rac3 gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Canonical Pathways
- M226 Pid vegfr1 pathway
- M193 Pid nephrin neph1 pathway
- M108 Pid netrin pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
1,118
Mass
122,294
Sequence
MARSPGRAYALLLLLICFNVGSGLHLQVLSTRNENKLLPKHPHLVRQKRAWITAPVALREGEDLSKKNPIAKIHSDLAEERGLKITYKYTGKGITEPPFGIFVFNKDTGELNVTSILDREETPFFLLTGYALDARGNNVEKPLELRIKVLDINDNEPVFTQDVFVGSVEELSAAHTLVMKINATDADEPNTLNSKISYRIVSLEPAYPPVFYLNKDTGEIYTTSVTLDREEHSSYTLTVEARDGNGEVTDKPVKQAQVQIRILDVNDNIPVVENKVLEGMVEENQVNVEVTRIKVFDADEIGSDNWLANFTFASGNEGGYFHIETDAQTNEGIVTLIKEVDYEEMKNLDFSVIVANKAAFHKSIRSKYKPTPIPIKVKVKNVKEGIHFKSSVISIYVSESMDRSSKGQIIGNFQAFDEDTGLPAHARYVKLEDRDNWISVDSVTSEIKLAKLPDFESRYVQNGTYTVKIVAISEDYPRKTITGTVLINVEDINDNCPTLIEPVQTICHDAEYVNVTAEDLDGHPNSGPFSFSVIDKPPGMAEKWKIARQESTSVLLQQSEKKLGRSEIQFLISDNQGFSCPEKQVLTLTVCECLHGSGCREAQHDSYVGLGPAAIALMILAFLLLLLVPLLLLMCHCGKGAKGFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGRNGVGGMAKEATMKGSSSASIVKGQHEMSEMDGRWEEHRSLLSGRATQFTGATGAIMTTETTKTARATGASRDMAGAQAAAVALNEEFLRNYFTDKAASYTEEDENHTAKDCLLVYSQEETESLNASIGCCSFIEGELDDRFLDDLGLKFKTLAEVCLGQKIDINKEIEQRQKPATETSMNTASHSLCEQTMVNSENTYSSGSSFPVPKSLQEANAEKVTQEIVTERSVSSRQAQKVATPLPDPMASRNVIATETSYVTGSTMPPTTVILGPSQPQSLIVTERVYAPASTLVDQPYANEGTVVVTERVIQPHGGGSNPLEGTQHLQDVPYVMVRERESFLAPSSGVQPTLAMPNIAVGQNVTVTERVLAPASTLQSSYQIPTENSMTARNTTVSGAGVPGPLPDFGLEESGHSNSTITTSSTRVTKHSTVQHSYS
3D Structural Models
Turn
76..82; 92..94; 106..108; 119..121; 192..194; 215..217; 229..231; 304..306; 327..330; 342..345; 362..366; 401..403; 418..420; 442..444
Helix
65..67; 540..543
Beta Strand
56..59; 86..91; 95..98; 100..104; 110..113; 123..132; 134..136; 138..140; 143..150; 158..160; 162..169; 177..180; 189..191; 197..205; 211..213; 219..222; 233..242; 257..263; 278..282; 289..296; 307..315; 321..326; 331..336; 350..358; 373..380; 391..400; 409..412; 426..431; 438..440; 446..451; 464..477; 480..490; 498..500; 502..507; 513..518; 525..528; 544..549; 551..560; 564..570; 575..577; 584..591; 595..598
3D Structure
Electron microscopy (8); NMR spectroscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
1068..1077; Polar residues; 1095..1118; Polar residues
Repeat
881..912; Desmoglein repeat 1; 913..942; Desmoglein repeat 2; 943..968; Desmoglein repeat 3; 969..992; Desmoglein repeat 4; 993..1021; Desmoglein repeat 5; 1022..1051; Desmoglein repeat 6
Domain (CC)
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
50..160; Cadherin 1; 161..273; Cadherin 2; 274..388; Cadherin 3; 389..503; Cadherin 4
Region
1068..1118; Disordered