Protein detail
EFR3A
Protein EFR3 homolog A (Protein EFR3-like)
Entry name EFR3A | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protein EFR3 homolog A (Protein EFR3-like)
Protein Class (2)
Disease related genesPredicted intracellular proteins
Protein Function (2)
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
KIAA0143
Gene Description
EFR3 homolog A
Chromosome
8
Position
131904093-132013642
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cells
Function & Pathway
Protein Function (2)
- Disease related genes
- Predicted intracellular proteins
Cellular Component (2)
Biological Process (3)
Mediation Categories
Metabolism mediation
Relations & Evidence11
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | DGIdb | Yes | ||||
| receptor | receptor | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| EFR3A | Q14156 | PI4KA | P42356 | Yes | Yes | SIGNOR | SIGNOR:34504076 | |
| EFR3A | Q14156 | RASK | P01116 | Yes | Yes | SIGNOR | SIGNOR:34504076 |
Sequence, Structure & Domains
Sequences
Length
821
Mass
92,924
Sequence
MPTRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKTDMEKLTFYAVSAPEKLDRIGSYLAERLSRDVVRHRSGYVLIAMEALDQLLMACHSQSIKPFVESFLHMVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSCHSDPEIRTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEVDSRIGPPSSPSATDKEENPAVLAENCFRELLGRATFGNMNNAVRPVFAHLDHHKLWDPNEFAVHCFKIIMYSIQAQYSHHVIQEILGHLDARKKDAPRVRAGIIQVLLEAVAIAAKGSIGPTVLEVFNTLLKHLRLSVEFEANDLQGGSVGSVNLNTSSKDNDEKIVQNAIIQTIGFFGSNLPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQIMLLRSLLMVTSGYKAKTIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADLKIKREKICRQDTSFMKKNGQQLYRHIYLGCKEEDNVQKNYELLYTSLALITIELANEEVVIDLIRLAIALQDSAIINEDNLPMFHRCGIMALVAAYLNFVSQMIAVPAFCQHVSKVIEIRTMEAPYFLPEHIFRDKCMLPKSLEKHEKDLYFLTNKIAESLGGSGYSVERLSVPYVPQVTDEDRLSRRKSIVDTVSIQVDILSNNVPSDDVVSNTEEITFEALKKAIDTSGMEEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSGTLTITSGHAQYQSVPVYEMKFPDLCVY
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14156-1; Sequence=Displayed; Name=2; IsoId=Q14156-2; Sequence=VSP_022217; Name=3; IsoId=Q14156-3; Sequence=VSP_022218
Alternative Sequence
1..36; Missing (in isoform 2); 619..662; Missing (in isoform 3)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Protein Families
EFR3 family
Sequence Similarities
Belongs to the EFR3 family.
Clinical Relevance
Disease Involvement (2)
AutismAutism spectrum disorder
Related Diseases (2)
Drugs (2)
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |