Protein detail
SCRIB
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Entry name SCRIB | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 9 | Transmembrane count | Protein classification Disease related genesPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Protein Class (2)
Disease related genesPredicted intracellular proteins
Protein Function (2)
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
KIAA0147SCRB1Vartul
Gene Description
Scribble planar cell polarity protein
Chromosome
8
Position
143790920-143815773
Supporting publications (n)
9
EVMP confidence score
0.63
Fluorescence & Localization3
Tissue Specificskeletal muscleCell SpecificAlveolar cells type 1
Function & Pathway8
Protein Function (2)
- Disease related genes
- Predicted intracellular proteins
Cellular Component (19)
- GO:0001772 immunological synapse
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005912 adherens junction
- GO:0014069 postsynaptic density
- GO:0016323 basolateral plasma membrane
- GO:0030027 lamellipodium
- GO:0030054 cell junction
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Molecular Function (4)
Biological Process (3)
KEGG (4)
Reactome (11)
- R-hsa-4608870 asymmetric localization of pcp proteins
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-4086400 pcp ce pathway
- R-hsa-9013409 rhoj gtpase cycle
- R-hsa-9013406 rhoq gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9696270 rnd2 gtpase cycle
- R-hsa-9696264 rnd3 gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
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Canonical Pathways (2)
- M235 Pid tcr calcium pathway
- M113 Pid nfat 3pathway
Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence49
Enzyme-Mediated Modification (7)
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SCRIB | PRKACA | P17612 | S | 1,445 | phosphorylation | SIGNOR | SIGNOR:20622900 |
| SCRIB | ROCK1 | Q13464 | S | 1,508 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| SCRIB | ROCK1 | Q13464 | S | 1,378 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| SCRIB | RHOA | P61586 | S | 1,508 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:26101221 |
| SCRIB | EGF | P01133 | S | 1,223 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
| SCRIB | EGF | P01133 | S | 1,225 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
| SCRIB | EGF | P01133 | S | 1,348 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| adherens_junction | adherens_junction | Ramilowski_location | No | Yes | No | No | No |
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Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| UBE3A | Q05086 | SCRIB | Q14160 | Yes | No | Yes | HINTSIGNORBioGRIDSPIKE_LC | SIGNOR:11027293HINT:16482544BioGRID:16482544HINT:11027293SPIKE_LC:11027293 |
| CTNB1 | P35222 | SCRIB | Q14160 | Yes | Yes | No | SIGNOR | SIGNOR:21255999 |
| ROCK1 | Q13464 | SCRIB | Q14160 | Yes | No | No | iPTMnetPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:26101221 |
Protein Complex Composition (21)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting | 1 | 29148239 |
Sequence, Structure & Domains16
Sequences
Length
1,655
Mass
177,724
Sequence
MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPPSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQRLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLPLSGKKFDYRAFAALPSSRPVYDIQSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=3; IsoId=Q14160-3; Sequence=Displayed; Name=1; IsoId=Q14160-1; Sequence=VSP_062397; Name=2; Synonyms=Variant N1; IsoId=Q14160-2; Sequence=VSP_062396, VSP_062397
Alternative Sequence
1..81; Missing (in isoform 2); 1566..1590; Missing (in isoform 2 and isoform 1)
3D Structural Models
Turn
1027..1030
Helix
768..772; 793..801; 820..823; 902..906; 928..936; 1046..1049; 1071..1078; 1129..1131; 1144..1148; 1170..1177
Beta Strand
710..712; 715..717; 725..732; 734..736; 740..744; 751..754; 757..763; 765..767; 779..783; 805..814; 815..818; 860..866; 874..878; 892..898; 914..918; 940..947; 997..1000; 1002..1008; 1010..1012; 1016..1020; 1022..1024; 1031..1033; 1036..1041; 1043..1045; 1057..1061; 1080..1090; 1099..1104; 1113..1117; 1119..1122; 1126..1128; 1134..1139; 1141..1143; 1156..1160; 1181..1189
3D Structure
NMR spectroscopy (4); X-ray crystallography (32)
Domain & Motif Annotations
Compositional Bias
479..494; Basic and acidic residues; 537..555; Low complexity; 556..565; Acidic residues; 660..694; Acidic residues; 829..841; Basic and acidic residues; 1227..1242; Basic and acidic residues; 1302..1311; Pro residues; 1353..1365; Basic and acidic residues; 1383..1395; Basic and acidic residues; 1409..1421; Low complexity; 1422..1432; Acidic residues; 1461..1472; Basic and acidic residues; 1524..1537; Basic and acidic residues
Repeat
37..58; LRR 1; 60..81; LRR 2; 83..104; LRR 3; 106..127; LRR 4; 129..150; LRR 5; 152..174; LRR 6; 175..197; LRR 7; 198..219; LRR 8; 221..243; LRR 9; 244..265; LRR 10; 267..288; LRR 11; 290..312; LRR 12; 313..334; LRR 13; 336..357; LRR 14; 359..381; LRR 15; 382..402; LRR 16
Coiled Coil
458..474; 656..701; 1379..1419
Domain (FT)
728..815; PDZ 1; 862..950; PDZ 2; 1004..1093; PDZ 3; 1100..1194; PDZ 4
Region
1..818; Sufficient for targeting to adherens junction and to inhibit cell proliferation; 417..440; Disordered; 459..606; Disordered; 628..702; Disordered; 717..1229; Interaction with ARHGEF7; 728..1194; Required for interaction with VIM; 827..853; Disordered; 1105..1117; Interaction with tick-borne encephalitis virus RNA-directed RNA polymerase NS5; 1227..1246; Disordered; 1277..1489; Disordered; 1520..1568; Disordered; 1622..1655; Disordered
Protein Families
LAP (LRR and PDZ) protein family
Sequence Similarities
Belongs to the LAP (LRR and PDZ) protein family.
Clinical Relevance6
Disease Involvement
Disease variant
Drug Targets
Literature-reported target
Interaction Protein (8)
ENSG00000018408ENSG00000081913ENSG00000102606ENSG00000102882ENSG00000108262ENSG00000119139ENSG00000129295ENSG00000165409
Interaction Count
8
Interaction Dataset
intact_biogrid
Supporting Publications9
| PMID | Title | Abstract |
|---|---|---|
| 29891991 | Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion. | No abstract available |
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No abstract available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No abstract available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No abstract available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |