Protein detail
SRC8
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Protein symbol SRC8 | UniProt ID | EVMP score 0.63 |
Frequency 7 | Transmembrane count | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Protein Class
Cancer-related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
EMS1
Gene Description
Cortactin
Chromosome
11
Position
70398404-70436584
Frequency
7
EVMP Score
0.63
Fluorescence & Localization
Cell SpecificEarly spermatids
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
Cellular Component
- GO:0001726 ruffle
- GO:0002102 podosome
- GO:0005737 cytoplasm
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0005925 focal adhesion
- GO:0005938 cell cortex
- GO:0008076 voltage-gated potassium channel complex
- GO:0030027 lamellipodium
- GO:0030139 endocytic vesicle
- GO:0030426 growth cone
- GO:0030863 cortical cytoskeleton
- GO:0043197 dendritic spine
- GO:0043231 intracellular membrane-bounded organelle
- GO:1990023 mitotic spindle midzone
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
193 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CTTN | CDK2 | P24941 | S | 405 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| CTTN | CDK2 | P24941 | S | 368 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CTTN | CDK2 | P24941 | S | 418 | phosphorylation | KEA | KEA:17570479 |
| CTTN | PRKD2 | Q9BZL6 | S | 298 | phosphorylation | PhosphoSite | |
| CTTN | ATM | Q13315 | S | 113 | phosphorylation | PhosphoSite | |
| CTTN | FYN | P06241 | Y | 470 | phosphorylation | PhosphoSite | |
| CTTN | FYN | P06241 | Y | 446 | phosphorylation | RLIMS-P_ProtMapperPhosphoSiteProtMapper | ProtMapper:27363897 |
| CTTN | FYN | P06241 | Y | 486 | phosphorylation | PhosphoSite | |
| CTTN | FYN | P06241 | Y | 421 | phosphorylation | PhosphoSite | |
| CTTN | FYN | P06241 | Y | 453 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| actin_regulation_adhesome | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
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Regulatory Interaction Network
23 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SRC8 | Q14247 | COMPLEX:O15144_O15145_O15511_P59998_P61158_P61160_Q92747 | Yes | Yes | No | SIGNOR | SIGNOR:11231575 | |
| KPCD3 | O94806 | SRC8 | Q14247 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:24753582PhosphoSite:31727638PhosphoSite:19038333PhosphoSite:27179075PhosphoSite:20363754 |
| CDK2 | P24941 | SRC8 | Q14247 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPiPTMnetProtMapperKEAPhosphoSiteNetworKIN_KEA | PhosphoSite:21856159PhosphoSite:21079800PhosphoSite:26490115PhosphoSite:24867096PhosphoSite:20444238PhosphoSite:10537323PhosphoSite:24188565KEA:17570479PhosphoSite:27363897 |
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Protein Complex Composition
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CTTN-FER-PTK2 complex | CTTNFERPTK2 | P16591Q05397Q14247 | 0:0:0 | CORUM | CORUM:6916 | 19339212 |
| G alpha-13-Hax-1-cortactin-Rac complex | AKT1CTTNGNA13HAX1 | O00165P31749Q14247Q14344 | 0:0:0:0 | CORUM | CORUM:6282 | 15339924 |
| c-Abl-cortactin-nmMLCK complex | ABL1CTTNMYLK | P00519Q14247Q15746 | 0:0:0 | CORUM | CORUM:6076 | 20861316 |
| CTTNWIPF1 | O43516Q14247 | 1:1 | PDB | PDB:9eznPDB:9ezpPDB:9ezo | ||
| C19orf53CTTNHNRNPUSPATS2 | Q00839Q14247Q86XZ4Q9UNZ5 | 0:0:0:0 | hu.MAP | |||
| C19orf53CTTNHNRNPUTHAP11 | Q00839Q14247Q96EK4Q9UNZ5 | 0:0:0:0 | hu.MAP | |||
| CTTNPRRC2BPRRC2C | Q14247Q5JSZ5Q9Y520 | 0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
550
Mass
61,586
Sequence
MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14247-1; Sequence=Displayed; Name=2; IsoId=Q14247-2; Sequence=VSP_043120, VSP_043121; Name=3; IsoId=Q14247-3; Sequence=VSP_043120
Alternative Sequence
264..300; Missing (in isoform 2 and isoform 3); 538..550; YGLFPANYVELRQ -> FRELAFSCVRVALVPIKCSRDLPGQARGLRSALWRVGRKDCPRRGASSRVSLLGRRGLGLMEVNPELSHPEHRSCHVRWEICLCHTVTARRIRKLISFLRSREAGPVPSCSQVGGVSFQKVTWKCLGTWVPECP (in isoform 2)
3D Structural Models
Helix
543..545
Beta Strand
497..499; 506..510; 518..523; 526..534; 537..542; 546..548
3D Structure
NMR spectroscopy (4); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
17..27; Acidic residues; 357..396; Basic and acidic residues
Repeat
80..116; Cortactin 1; 117..153; Cortactin 2; 154..190; Cortactin 3; 191..227; Cortactin 4; 228..264; Cortactin 5; 265..301; Cortactin 6; 302..324; Cortactin 7; truncated
Coiled Coil
348..401
Domain (CC)
The SH3 motif may mediate binding to the cytoskeleton.
Domain (FT)
492..550; SH3
Region
1..27; Disordered; 344..419; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs
Interaction Protein
ENSG00000094631ENSG00000111229ENSG00000113758ENSG00000115091ENSG00000126016ENSG00000136068ENSG00000136754ENSG00000138071ENSG00000146648ENSG00000153317ENSG00000159251ENSG00000163466ENSG00000196924ENSG00000198898
Interaction Count
14
Interaction Dataset
intact_biogridbiogrid_opencell