Protein detail
SRC8
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Protein symbol SRC8 | UniProt ID | EVMP score 0.63 |
Frequency 7 | Transmembrane count | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Protein Class
Cancer-related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
EMS1
Gene Description
Cortactin
Chromosome
11
Position
70398404-70436584
Frequency
7
EVMP Score
0.63
Fluorescence & Localization
Cell SpecificEarly spermatids
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
Cellular Component
- GO:0001726 ruffle
- GO:0002102 podosome
- GO:0005737 cytoplasm
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0005905 clathrin-coated pit
- GO:0005925 focal adhesion
- GO:0005938 cell cortex
- GO:0008076 voltage-gated potassium channel complex
- GO:0030027 lamellipodium
- GO:0030139 endocytic vesicle
- GO:0030426 growth cone
- GO:0030863 cortical cytoskeleton
- GO:0043197 dendritic spine
- GO:0043231 intracellular membrane-bounded organelle
- GO:1990023 mitotic spindle midzone
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
193 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CTTN | FYN | P06241 | Y | 384 | phosphorylation | PhosphoNetworks | |
| CTTN | FYN | P06241 | Y | 433 | phosphorylation | PhosphoNetworks | |
| CTTN | GSK3B | P49841 | S | 113 | phosphorylation | PhosphoNetworks | |
| CTTN | GSK3B | P49841 | T | 364 | phosphorylation | PhosphoNetworks | |
| CTTN | GSK3B | P49841 | S | 368 | phosphorylation | PhosphoNetworks | |
| CTTN | GSK3B | P49841 | S | 405 | phosphorylation | KEA | KEA:17570479 |
| CTTN | GSK3B | P49841 | S | 418 | phosphorylation | KEA | KEA:17570479 |
| CTTN | GSK3B | P49841 | T | 401 | phosphorylation | KEA | KEA:17570479 |
| CTTN | PRKCA | P17252 | S | 117 | phosphorylation | PhosphoNetworks | |
| CTTN | PRKCH | C0HM02 | S | 117 | phosphorylation | PhosphoNetworks |
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| actin_regulation_adhesome | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
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Regulatory Interaction Network
23 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CT2NL | Q9P2B4 | SRC8 | Q14247 | Yes | Yes | No | SIGNOR | SIGNOR:23015759 |
| PTN1 | P18031 | SRC8 | Q14247 | Yes | Yes | No | AdhesomeSIGNORProtMapperDEPODSIGNOR_ProtMapperREACH_ProtMapperSPIKE_LC | SPIKE_LC:18387954Adhesome:18387954SIGNOR:18387954ProtMapper:27824079Adhesome:18515860DEPOD:18387954ProtMapper:18387954SIGNOR:27824079 |
| KPCD1 | Q15139 | SRC8 | Q14247 | Yes | No | Yes | Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | ProtMapper:21680539ProtMapper:19038333SIGNOR:20363754ProtMapper:29152154ProtMapper:31727638ProtMapper:26490115ProtMapper:20363754SIGNOR:19038333 |
| PTPRG | P23470 | SRC8 | Q14247 | Yes | No | Yes | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:25624455ProtMapper:25624455 |
| PTN6 | P29350 | SRC8 | Q14247 | Yes | No | Yes | SIGNOR | SIGNOR:34088320 |
| FGFR1 | P11362 | SRC8 | Q14247 | Yes | No | Yes | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapper | phosphoELM:12601080KEA:15951569KEA:15592455SIGNOR:12601080ProtMapper:12601080KEA:12601080 |
| COMPLEX:O15399_Q05586 | SRC8 | Q14247 | Yes | Yes | No | SIGNOR | SIGNOR:14684878 | |
| COMPLEX:Q05586_Q13224 | SRC8 | Q14247 | Yes | Yes | No | SIGNOR | SIGNOR:14684878 | |
| CTTB2 | Q8WZ74 | SRC8 | Q14247 | Yes | Yes | No | HPRDSIGNOR | SIGNOR:22262902HPRD:9813110 |
| COMPLEX:Q05586_Q12879 | SRC8 | Q14247 | Yes | Yes | No | SIGNOR | SIGNOR:14684878 |
Protein Complex Composition
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CTTN-FER-PTK2 complex | CTTNFERPTK2 | P16591Q05397Q14247 | 0:0:0 | CORUM | CORUM:6916 | 19339212 |
| G alpha-13-Hax-1-cortactin-Rac complex | AKT1CTTNGNA13HAX1 | O00165P31749Q14247Q14344 | 0:0:0:0 | CORUM | CORUM:6282 | 15339924 |
| c-Abl-cortactin-nmMLCK complex | ABL1CTTNMYLK | P00519Q14247Q15746 | 0:0:0 | CORUM | CORUM:6076 | 20861316 |
| CTTNWIPF1 | O43516Q14247 | 1:1 | PDB | PDB:9eznPDB:9ezpPDB:9ezo | ||
| C19orf53CTTNHNRNPUSPATS2 | Q00839Q14247Q86XZ4Q9UNZ5 | 0:0:0:0 | hu.MAP | |||
| C19orf53CTTNHNRNPUTHAP11 | Q00839Q14247Q96EK4Q9UNZ5 | 0:0:0:0 | hu.MAP | |||
| CTTNPRRC2BPRRC2C | Q14247Q5JSZ5Q9Y520 | 0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
550
Mass
61,586
Sequence
MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14247-1; Sequence=Displayed; Name=2; IsoId=Q14247-2; Sequence=VSP_043120, VSP_043121; Name=3; IsoId=Q14247-3; Sequence=VSP_043120
Alternative Sequence
264..300; Missing (in isoform 2 and isoform 3); 538..550; YGLFPANYVELRQ -> FRELAFSCVRVALVPIKCSRDLPGQARGLRSALWRVGRKDCPRRGASSRVSLLGRRGLGLMEVNPELSHPEHRSCHVRWEICLCHTVTARRIRKLISFLRSREAGPVPSCSQVGGVSFQKVTWKCLGTWVPECP (in isoform 2)
3D Structural Models
Helix
543..545
Beta Strand
497..499; 506..510; 518..523; 526..534; 537..542; 546..548
3D Structure
NMR spectroscopy (4); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
17..27; Acidic residues; 357..396; Basic and acidic residues
Repeat
80..116; Cortactin 1; 117..153; Cortactin 2; 154..190; Cortactin 3; 191..227; Cortactin 4; 228..264; Cortactin 5; 265..301; Cortactin 6; 302..324; Cortactin 7; truncated
Coiled Coil
348..401
Domain (CC)
The SH3 motif may mediate binding to the cytoskeleton.
Domain (FT)
492..550; SH3
Region
1..27; Disordered; 344..419; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs
Interaction Protein
ENSG00000094631ENSG00000111229ENSG00000113758ENSG00000115091ENSG00000126016ENSG00000136068ENSG00000136754ENSG00000138071ENSG00000146648ENSG00000153317ENSG00000159251ENSG00000163466ENSG00000196924ENSG00000198898
Interaction Count
14
Interaction Dataset
intact_biogridbiogrid_opencell