Protein detail
FAK2
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Entry name FAK2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Protein Class
Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
CADTKCAKBFAK2PTKPYK2RAFTK
Gene Description
Protein tyrosine kinase 2 beta
Chromosome
8
Position
27311482-27459391
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificNeutrophil progenitors
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Cellular Component
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0005938 cell cortex
- GO:0014069 postsynaptic density
- GO:0017146 NMDA selective glutamate receptor complex
- GO:0030027 lamellipodium
- GO:0030425 dendrite
- GO:0030426 growth cone
- GO:0043025 neuronal cell body
- GO:0043197 dendritic spine
- GO:0044297 cell body
- GO:0048471 perinuclear region of cytoplasm
- GO:0097440 apical dendrite
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0098793 presynapse
- GO:0098978 glutamatergic synapse
- GO:0099092 postsynaptic density, intracellular component
Molecular Function
- GO:0004683 calcium/calmodulin-dependent protein kinase activity
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0035254 glutamate receptor binding
- GO:0043423 3-phosphoinositide-dependent protein kinase binding
- GO:0044877 protein-containing complex binding
- GO:0099602 neurotransmitter receptor regulator activity
Biological Process
KEGG
- hsa04020 Calcium signaling pathway
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa05135 Yersinia infection
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
Reactome
- R-hsa-1500931 cell cell communication
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-451927 interleukin 2 family signaling
- R-hsa-9020558 interleukin 2 signaling
- R-hsa-9013420 rhou gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-449147 signaling by interleukins
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-194138 signaling by vegf
- R-hsa-391160 signal regulatory protein family interactions
Canonical Pathways
- M72 Pid nectin pathway
- M232 Pid ecadherin stabilization pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
40 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PTK2B | EGF | P01133 | Y | 402 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:26084289 |
| PTK2B | AGT | P01019 | Y | 402 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:21852560 |
| PTK2B | NRG1 | Q02297 | Y | 402 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:26084289 |
| PTK2B | HRG | P04196 | Y | 402 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:26084289 |
| PTK2B | FN1 | P02751 | Y | 402 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:26866924 |
| PTK2B | FYN | P06241 | Y | 402 | phosphorylation | KEA | KEA:17570479 |
| PTK2B | HCK | P08631 | Y | 580 | phosphorylation | KEA | KEA:17570479 |
| PTK2B | IGF1R | P08069 | Y | 579 | phosphorylation | KEA | KEA:17570479 |
| PTK2B | LYN | P07948 | Y | 579 | phosphorylation | KEA | KEA:17570479 |
| PTK2B | PRKDC | P78527 | S | 375 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
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Regulatory Interaction Network
29 records.
Page 3 of 3Previous
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ArgBP2a-CBL-PTK2B complex | CBLPTK2BSORBS2 | O94875P22681Q14289 | 1:1:1 | CompleatCORUM | CORUM:5709Compleat:HC1811 | 15128873 |
| LPXNPTK2B | O60711Q14289 | 4:2 | PDB | PDB:4xefPDB:4xevPDB:4xek | ||
| PTK2BPXN | P49023Q14289 | 4:2 | PDB | PDB:3u3fPDB:3gm1PDB:4r32 | ||
| PTK2B | Q14289 | 6 | PDB | PDB:6lf3 | ||
| PTK2BUFC1 | Q14289Q9Y3C8 | 0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
1,009
Mass
115,875
Sequence
MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14289-1; Sequence=Displayed; Name=2; Synonyms=PYK2H; IsoId=Q14289-2; Sequence=VSP_004981
Alternative Sequence
739..780; Missing (in isoform 2)
3D Structural Models
Turn
77..80; 119..121; 138..140; 166..169; 187..189; 314..316; 518..520; 620..622; 625..628; 963..965
Helix
35..37; 52..54; 67..76; 87..89; 111..117; 124..126; 141..144; 148..165; 172..186; 194..196; 198..207; 210..212; 216..221; 224..238; 243..254; 302..304; 338..355; 422..424; 465..481; 510..517; 523..542; 552..554; 570..572; 589..591; 594..599; 604..619; 631..633; 634..640; 652..661; 666..668; 672..691; 879..897; 898..900; 903..905; 906..927; 928..930; 933..962; 969..1004
Beta Strand
38..45; 48..50; 55..62; 90..99; 102..105; 127..133; 263..273; 277..282; 285..289; 297..300; 310..313; 317..322; 331..336; 356..360; 425..433; 435..445; 447..449; 451..458; 461..463; 489..493; 495..497; 499..503; 546..548; 555..559; 562..565
3D Structure
NMR spectroscopy (2); X-ray crystallography (24)
Domain & Motif Annotations
Compositional Bias
712..725; Pro residues
Domain (FT)
39..359; FERM; 425..683; Protein kinase; 870..1000; Focal AT
Region
701..725; Disordered; 801..1009; Interaction with TGFB1I1; 868..1009; Focal adhesion targeting (FAT)
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- FAK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
Clinical Relevance
Drug Targets
Literature-reported target
Drugs
GILTERITINIBMASITINIBNULLCHEMBL:CHEMBL261692LUCITANIBZEARALENONECABOZANTINIB S-MALATECOMPOUND 1 [PMID: 34917254]QUIZARTINIBTAFETINIBRG-1530ABROCITINIBCENISERTIBAST-487WF-47-JS03PONATINIBZETELETINIBBARICITINIBCOMPOUND 1D [PMID: 21493067]VEPAFESTINIBSORAFENIBLINIFANIBDELGOCITINIBCHEMBL:CHEMBL600336PRALSETINIBDEFACTINIBILORASERTIBCHEMBL:CHEMBL580819COMPOUND 8H [PMID: 21561767]SELPERCATINIBRESENCATINIBCHEMBL:CHEMBL374632RIVOCERANIBVANDETANIBPF-562271CONTELTINIBIZENCITINIBUPADACITINIBPEFICITINIBHESPERADINCEP-11981TAMATINIBGW843682XKBP-7018SUNITINIBTESEVATINIBCHEMBL:CHEMBL1576310
Interaction Protein
ENSG00000010810
Interaction Count
1
Interaction Dataset
intact_biogrid