EV MemProt Atlas

Basic Information

Protein Names

Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)

Protein Class

Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes

Ensembl

ENSG00000120899

Entrez Gene Symbol

PTK2B

Gene Synonym

CADTKCAKBFAK2PTKPYK2RAFTK

Gene Description

Protein tyrosine kinase 2 beta

Chromosome

8

Position

27311482-27459391

Frequency

1

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificNeutrophil progenitors

Function & Pathway

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M72 Pid nectin pathway
M232 Pid ecadherin stabilization pathway

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

40 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PTK2B	PTPN12	Q05209	Y	402	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:11337490
PTK2B	PTPN12	Q05209	Y	579	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:11337490
PTK2B	PTPN12	Q05209	Y	580	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:11337490
PTK2B	PTPN6	P29350	Y	402	dephosphorylation	SIGNOR	SIGNOR:10521452
PTK2B	PTPN6	P29350	Y	402	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:10521452
PTK2B	PTPN11	Q06124	Y	906	dephosphorylation	HPRD	HPRD:10880513
PTK2B	PTPN11	Q06124	Y	864	dephosphorylation	HPRD	HPRD:10880513
PTK2B	PTPN11	Q06124	Y	906	phosphorylation	MIMPHPRD_MIMPKEAPhosphoSite_MIMP	KEA:10880513
PTK2B	PTPN11	Q06124	Y	864	phosphorylation	KEA	KEA:10880513
PTK2B	INSR	P06213	Y	402	phosphorylation	Li2012KEA	KEA:17570479

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Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
gpcr	receptor	DGIdb	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ferm_domain	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Regulatory Interaction Network

29 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FAK2	Q14289	STAP1	Q9ULZ2	Yes	Yes	No	WangPhosphoPointSIGNORHPRDSPIKE_LCSPIKE	SIGNOR:10518561 HPRD:10518561 SPIKE_LC:10518561 SPIKE:10518561
PTN11	Q06124	FAK2	Q14289	Yes	No	Yes	SPIKEWangAdhesomeMIMPNetPathHPRD_MIMPPhosphoSite_MIMPSIGNORiPTMnetProtMapperDEPODHPRDPhosphoSite_KEAKEAHPRD_KEASPIKE_LCLit-BM-17HPRD-phos	Adhesome:10880513 Lit-BM-17:10880513 HPRD:10880513 SIGNOR:10880513 KEA:10880513 SPIKE:10880513 SPIKE_LC:10880513 HPRD-phos:10880513 ProtMapper:10880513 DEPOD:10880513 NetPath:10880513
FAK2	Q14289	PAXI	P49023	Yes	No	Yes	WangSparser_ProtMapperAdhesomeNetPathPhosphoPointSIGNORProtMapperREACH_ProtMapperHPRDELMCui2007HINTLMPIDSPIKE_LCLit-BM-17SPIKE	Adhesome:11820787 ELM:14527389 ELM:19358827 HPRD:9099734 Lit-BM-17:9422762 Adhesome:9422762 HINT:19358827 HINT:9422762 Adhesome:9366396 HINT:32707033 Adhesome:9099734 Adhesome:11036077 NetPath:9091579 HINT:9099734 SPIKE:9091579 LMPID:19358827 SPIKE_LC:9091579 Lit-BM-17:9099734 SIGNOR:15263022 HINT:25174335 ProtMapper:29438996 SPIKE:16713569 ProtMapper:20116462 ProtMapper:22581436 ProtMapper:30571746 Lit-BM-17:11036077 SPIKE_LC:16713569 Lit-BM-17:10980697
SRC	P12931	FAK2	Q14289	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTdbPTMSignaLink3InnateDBLi2012HPRDCui2007Kinexus_KEAIntActCancerCellMapWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointELMKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteTCRcuration_SignaLink3Sparser_ProtMapperAdhesomeNetPathSPIKE_LCSPIKE	SPIKE_LC:14963038 HINT:14963038 Adhesome:10777553 Adhesome:14739300 SignaLink3:23109003 ProtMapper:12967635 PhosphoSite:15778498 dbPTM:19534553 PhosphoSite:12231407 SignaLink3:12495636 dbPTM:20028775 PhosphoSite:15105428 PhosphoSite:15166227 HINT:11149930 dbPTM:20521079 InnateDB:14963038 HINT:10521452 Adhesome:14963038 Adhesome:12345678 PhosphoSite:12526812 IntAct:10521452 dbPTM:17192257 Adhesome:11149930 SPIKE:14963038 ProtMapper:20521079 dbPTM:19369195 CancerCellMap:14963038 ELM:11149930 dbPTM:18083107 ELM:10521452 PhosphoSite:15070849 dbPTM:20381867 SignaLink3:10593973 PhosphoSite:22581436 dbPTM:17389395 HINT:8849729 ELM:10867021 PhosphoSite:25349423 Adhesome:19380485 PhosphoSite:12486027 IntAct:11149930 ProtMapper:23587524 NetPath:14963038 PhosphoSite:15585656 Adhesome:10329689 KEA:15070849 SIGNOR:15695828 SPIKE:16713569 HPRD:10777553 Adhesome:11274221 PhosphoSite:19919693 KEA:15585656 PhosphoSite:31979355 ProtMapper:26866924 IntAct:8849729 ProtMapper:20001213 ProtMapper:15695828 Adhesome:10521452 HPRD:8849729 Adhesome:9560226 ELM:8849729 SPIKE_LC:16713569 SignaLink3:7529876 Adhesome:8849729 Adhesome:9556630 dbPTM:12522270
FAK2	Q14289	SRC	P12931	Yes	Yes	No	KEGG-MEDICUSProtMapperHINTSignaLink3InnateDBLi2012NCI-PID_ProtMapperHPRDCui2007CA1IntActCancerCellMapWangELMTCRcuration_SignaLink3AdhesomeNetPathSPIKE_LCSPIKE	SPIKE_LC:14963038 HINT:14963038 Adhesome:10777553 Adhesome:14739300 SignaLink3:23109003 CA1:10329689 HINT:11149930 InnateDB:14963038 HINT:10521452 Adhesome:14963038 Adhesome:12345678 IntAct:10521452 Adhesome:11149930 SPIKE:14963038 CancerCellMap:14963038 ELM:11149930 ELM:10521452 HINT:8849729 CA1:9560226 ELM:10867021 Adhesome:19380485 IntAct:11149930 SignaLink3:9148935 NetPath:14963038 Adhesome:10329689 CA1:8849729 SPIKE:16713569 HPRD:10777553 Adhesome:11274221 IntAct:8849729 CA1:11274221 Adhesome:10521452 HPRD:8849729 Adhesome:9560226 ELM:8849729 SPIKE_LC:16713569 Adhesome:8849729 Adhesome:9556630
JAK3	P52333	FAK2	Q14289	Yes	Yes	No	WangNetPathPhosphoPointHPRDSignaLink3SPIKE_LCSPIKE	HPRD:9512511 SignaLink3:9512511 NetPath:9512511 SPIKE_LC:9512511 SignaLink3:23331499 SPIKE:9512511 SignaLink3:21071413
FGR	P09769	FAK2	Q14289	Yes	Yes	No	WangSignaLink3TCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:12495636 SignaLink3:10593973 SignaLink3:7529876
FAK2	Q14289	FGR	P09769	Yes	Yes	No	PhosphoNetworksNCI-PID_ProtMapperProtMapperSignaLink3WangTCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:9148935
HCK	P08631	FAK2	Q14289	Yes	Yes	No	KEASignaLink3WangNetworKIN_KEATCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:12495636 SignaLink3:7529876 KEA:17570479 SignaLink3:10593973
FAK2	Q14289	HCK	P08631	Yes	Yes	No	NCI-PID_ProtMapperProtMapperSignaLink3WangTCRcuration_SignaLink3	SignaLink3:23109003 SignaLink3:9148935

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Protein Complex Composition

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ArgBP2a-CBL-PTK2B complex	CBL PTK2B SORBS2	O94875 P22681 Q14289	1:1:1	CompleatCORUM	CORUM:5709Compleat:HC1811	15128873
	LPXN PTK2B	O60711 Q14289	4:2	PDB	PDB:4xefPDB:4xevPDB:4xek
	PTK2B PXN	P49023 Q14289	4:2	PDB	PDB:3u3fPDB:3gm1PDB:4r32
	PTK2B	Q14289	6	PDB	PDB:6lf3
	PTK2B UFC1	Q14289 Q9Y3C8	0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Label-free LC-MS/MS	2	32384937 38071653

Sequence, Structure & Domains

Sequences

Length

1,009

Mass

115,875

Sequence

MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14289-1; Sequence=Displayed; Name=2; Synonyms=PYK2H; IsoId=Q14289-2; Sequence=VSP_004981

Alternative Sequence

739..780; Missing (in isoform 2)

3D Structural Models

Turn

77..80; 119..121; 138..140; 166..169; 187..189; 314..316; 518..520; 620..622; 625..628; 963..965

Helix

35..37; 52..54; 67..76; 87..89; 111..117; 124..126; 141..144; 148..165; 172..186; 194..196; 198..207; 210..212; 216..221; 224..238; 243..254; 302..304; 338..355; 422..424; 465..481; 510..517; 523..542; 552..554; 570..572; 589..591; 594..599; 604..619; 631..633; 634..640; 652..661; 666..668; 672..691; 879..897; 898..900; 903..905; 906..927; 928..930; 933..962; 969..1004

Beta Strand

38..45; 48..50; 55..62; 90..99; 102..105; 127..133; 263..273; 277..282; 285..289; 297..300; 310..313; 317..322; 331..336; 356..360; 425..433; 435..445; 447..449; 451..458; 461..463; 489..493; 495..497; 499..503; 546..548; 555..559; 562..565

3D Structure

NMR spectroscopy (2); X-ray crystallography (24)

Domain & Motif Annotations

Compositional Bias

712..725; Pro residues

Domain (FT)

39..359; FERM; 425..683; Protein kinase; 870..1000; Focal AT

Region

701..725; Disordered; 801..1009; Interaction with TGFB1I1; 868..1009; Focal adhesion targeting (FAT)

Protein Families

Protein kinase superfamily
Tyr protein kinase family
FAK subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.

Clinical Relevance

Drug Targets

Literature-reported target

Antibody

CAB003850 HPA026091 HPA026276

Interaction Protein

ENSG00000010810

Interaction Count

1

Interaction Dataset

intact_biogrid

Protein symbol FAK2	UniProt ID Q14289	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Disease related genesEnzymesPlasma proteinsPotential drug targetsPredicted intracellular proteins