Protein detail

FLNC

Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)

Protein symbol FLNC	UniProt ID Q14315	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)

Protein Class

Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters

Protein Function

Predicted intracellular proteins
Potential drug targets
Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transporters:Accessory Factors Involved in Transport
Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases

Ensembl

ENSG00000128591

Entrez Gene Symbol

FLNC

Gene Synonym

ABP-280ABPLFLN2

Gene Description

Filamin C

Chromosome

Position

128830406-128859274

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificepididymisCell SpecificEpididymal efferent duct absorptive cells

Function & Pathway

Protein Function

Predicted intracellular proteins
Potential drug targets
Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transporters:Accessory Factors Involved in Transport
Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04820 Cytoskeleton in muscle cells

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

5 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FLNC	PRKCA	P17252	S	2,236	phosphorylation	SIGNOR	SIGNOR:32444788
FLNC	PRKCA	P17252	S	2,624	phosphorylation	PhosphoSite
FLNC	PRKCA	P17252	S	2,623	phosphorylation	PhosphoSite
FLNC	AKT2	P31751	S	2,233	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
FLNC	AKT1	P31749	S	2,233	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FBLI1	Q8WUP2	FLNC	Q14315	Yes	Yes	No	HINTSIGNOR	HINT:19074766 HINT:33961781 SIGNOR:24165133
KPCA	P17252	FLNC	Q14315	Yes	Yes	No	PhosphoSite_norefSIGNORProtMapperHPRDSIGNOR_ProtMapperPhosphoSite_ProtMapper	HPRD:12704190 ProtMapper:32444788 SIGNOR:32444788
FIL1L	Q4L180	FLNC	Q14315	Yes	No	Yes	SIGNOR	SIGNOR:32444788

Protein Complex Composition

7 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FLNC GP1BA	P07359 Q14315	1:1	PDB	PDB:4mgx
DDB1 EEF1D FLNC NUP133 SAP30BP TAF15	P29692 Q14315 Q16531 Q8WUM0 Q92804 Q9UHR5	0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_517
FLNC OGDH PFKP	Q01813 Q02218 Q14315	0:0:0	hu.MAP
FLNC	Q14315	2	PDB	PDB:7p0ePDB:7ouvPDB:3v8oPDB:7ouu
FBLIM1 FLNC	Q14315 Q8WUP2	1:1	PDB	PDB:2k9u
DPH5 FLNC HSPB7	Q14315 Q9H2P9 Q9UBY9	0:0:0	hu.MAP2
FLNC HSPB7	Q14315 Q9UBY9	1:1	hu.MAP2PDB	PDB:8pa0

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	37886648

Sequence, Structure & Domains

Sequences

Length

2,725

Mass

291,022

Sequence

MMNNSGYSDAGLGLGDETDEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAPGLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPAMEGPHTVHVAFAGAPITRSPFPVHVSEACNPNACRASGRGLQPKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSPEAGVQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKIKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACDPLPHEEEPSEVPQLRQPYAPPRPGARPTHWATEEPVVPVEPMESMLRPFNLVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVKVP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14315-1; Sequence=Displayed; Name=2; IsoId=Q14315-2; Sequence=VSP_007579

Alternative Sequence

1734..1766; Missing (in isoform 2)

3D Structural Models

Turn

1671..1673; 1885..1887; 2313..2316; 2323..2325; 2531..2533

Helix

579..581; 601..603; 667..669; 675..677; 1539..1541; 1547..1549; 1636..1638; 1867..1870; 2407..2410; 2505..2507; 2513..2515; 2635..2637; 2643..2645

Beta Strand

574..578; 583..585; 590..599; 604..612; 617..620; 622..630; 636..644; 653..659; 671..674; 678..680; 688..693; 697..699; 702..708; 717..720; 722..730; 734..744; 753..759; 1543..1546; 1554..1558; 1560..1565; 1569..1571; 1574..1579; 1589..1592; 1594..1602; 1606..1616; 1625..1631; 1640..1645; 1648..1653; 1656..1659; 1664..1669; 1678..1683; 1689..1692; 1694..1696; 1698..1706; 1710..1720; 1729..1735; 1785..1789; 1794..1796; 1798..1803; 1813..1816; 1818..1820; 1822..1826; 1832..1843; 1849..1854; 1863..1866; 1871..1873; 1878..1883; 1895..1900; 1910..1918; 1924..1929; 1931..1934; 1941..1947; 2303..2308; 2318..2322; 2332..2338; 2344..2355; 2358..2362; 2365..2374; 2377..2389; 2396..2404; 2427..2432; 2440..2445; 2447..2449; 2463..2468; 2474..2484; 2491..2496; 2509..2512; 2517..2519; 2524..2529; 2538..2546; 2549..2555; 2558..2564; 2569..2580; 2587..2594; 2639..2642; 2654..2659; 2663..2665; 2668..2673; 2675..2677; 2680..2686; 2691..2697; 2702..2710; 2719..2724

3D Structure

NMR spectroscopy (6); X-ray crystallography (8)

Domain & Motif Annotations

Compositional Bias

2240..2258; Polar residues

Repeat

270..368; Filamin 1; 370..468; Filamin 2; 469..565; Filamin 3; 566..658; Filamin 4; 662..758; Filamin 5; 759..861; Filamin 6; 862..960; Filamin 7; 961..1056; Filamin 8; 1057..1149; Filamin 9; 1150..1244; Filamin 10; 1245..1344; Filamin 11; 1345..1437; Filamin 12; 1438..1533; Filamin 13; 1534..1630; Filamin 14; 1635..1734; Filamin 15; 1759..1853; Filamin 16; 1854..1946; Filamin 17; 1947..2033; Filamin 18; 2036..2128; Filamin 19; 2244..2306; Filamin 20; mediates interaction with XIRP1; 2309..2401; Filamin 21; 2403..2496; Filamin 22; 2500..2592; Filamin 23; 2630..2724; Filamin 24

Domain (FT)

36..142; Calponin-homology (CH) 1; 159..262; Calponin-homology (CH) 2

Region

1..259; Actin-binding; 1..28; Disordered; 1735..1758; Hinge 1; 1740..1765; Disordered; 1947..2401; Required for interaction with PGM5; 2162..2243; Intradomain insert; mediate targeting to Z lines; 2240..2260; Disordered; 2403..2724; Interaction with INPPL1; 2593..2725; Self-association site, tail; 2593..2629; Hinge 2

Protein Families

Filamin family

Sequence Similarities

Belongs to the filamin family.

Clinical Relevance

Disease Involvement

CardiomyopathyDisease variantMyofibrillar myopathy

Antibody

HPA006135 HPA071007

Interaction Protein

ENSG00000102683ENSG00000135636ENSG00000168334ENSG00000170624ENSG00000177791ENSG00000197361

Interaction Count

Interaction Dataset

intact_biogrid