Protein detail
LRC32
Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32)
Entry name LRC32 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32)
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Predicted intracellular proteins
Transmembrane
628..648; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
4
EVMP confidence score
0.25
Fluorescence & Localization1
Cell SpecificAlveolar cells type 1
Function & Pathway7
Protein Function (3)
- Disease related genes
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
- M13 Pid erbb4 pathway
- M70 Pid ps1 pathway
- M237 Pid vegfr1 2 pathway
Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence34
Ligand-Receptor Signaling (32)
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| ecm | ecm | MatrixDB | Yes | No | No | Yes | No |
| ecm | ecm | OmniPath | Yes | No | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| growth_factor_binder | ligand_regulator | UniProt_keyword | Yes | No | No | Yes | No |
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Protein Complex Composition (1)
Sequence, Structure & Domains11
Sequences
Length
662
Mass
71,979
Sequence
MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLICRFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQYKA
3D Structural Models
Turn
90..94; 190..195; 293..295; 313..316; 338..340; 382..384; 403..407; 460..465; 483..488; 490..492; 553..555
Helix
66..69; 109..111; 112..115; 140..144; 261..263; 332..337; 510..512; 559..561; 579..586
Beta Strand
27..34; 37..39; 45..47; 52..55; 76..79; 101..103; 106..108; 116..118; 128..130; 153..155; 158..160; 177..179; 201..203; 211..214; 222..224; 231..233; 247..249; 269..271; 319..321; 343..345; 353..356; 362..364; 367..369; 376..380; 390..392; 414..416; 428..430; 433..435; 447..449; 469..472; 495..497; 518..520; 540..542; 565..567; 575..577; 587..590
3D Structure
Electron microscopy (5); X-ray crystallography (1)
Domain & Motif Annotations
Repeat
50..73; LRR 1; 74..95; LRR 2; 98..119; LRR 3; 125..145; LRR 4; 150..171; LRR 5; 174..195; LRR 6; 198..219; LRR 7; 220..240; LRR 8; 244..265; LRR 9; 266..286; LRR 10; 316..339; LRR 11; 340..363; LRR 12; 364..385; LRR 13; 387..408; LRR 14; 411..432; LRR 15; 444..465; LRR 16; 467..488; LRR 17; 492..513; LRR 18; 515..536; LRR 19; 537..558; LRR 20
Domain (FT)
21..48; LRRNT; 571..620; LRRCT
Protein Families
LRRC32/LRRC33 family
Sequence Similarities
Belongs to the LRRC32/LRRC33 family.
Clinical Relevance3
Related Diseases
Biomarker
Phase 1
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 28963552 | Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40928027 | Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes. | No abstract available |