Protein detail

LRC32

Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32)

Entry name LRC32	UniProt ID Q14392	EVMP confidence score 0.28
Supporting publications (n) 4	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32)

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Predicted intracellular proteins

Transmembrane

628..648; Helical

Transmembrane Count

Ensembl

ENSG00000137507

Entrez Gene Symbol

LRRC32

Supporting publications (n)

EVMP confidence score

0.28

Fluorescence & Localization

Cell SpecificAlveolar cells type 1

Function & Pathway

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04350 TGF-beta signaling pathway

Canonical Pathways (3)

M13 Pid erbb4 pathway
M70 Pid ps1 pathway
M237 Pid vegfr1 2 pathway

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence34

Ligand-Receptor Signaling (32)

32 records.

Category	Parent	Database	Transmitter	Receiver	Plasma Membrane (Transmembrane)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome			Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA			Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath			Yes
cell_surface	cell_surface	Surfaceome			Yes
cell_surface	cell_surface	OmniPath			Yes
ligand	ligand	GO_Intercell	Yes		Yes
ligand	ligand	OmniPath	Yes		Yes
receptor	receptor	scConnect		Yes	Yes
transmembrane	transmembrane_predicted	Phobius			Yes
transmembrane_phobius	transmembrane_predicted	Almen2009			Yes

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	LRRC32 TGFB3	P10600 Q14392	2:1	PDB	PDB:8vsb

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Label-free LC-MS/MS	2	32384937 38071653

Sequence, Structure & Domains

Sequences

Length

662

Mass

71,979

Sequence

MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLICRFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQYKA

3D Structural Models

Turn

90..94; 190..195; 293..295; 313..316; 338..340; 382..384; 403..407; 460..465; 483..488; 490..492; 553..555

Helix

66..69; 109..111; 112..115; 140..144; 261..263; 332..337; 510..512; 559..561; 579..586

Beta Strand

27..34; 37..39; 45..47; 52..55; 76..79; 101..103; 106..108; 116..118; 128..130; 153..155; 158..160; 177..179; 201..203; 211..214; 222..224; 231..233; 247..249; 269..271; 319..321; 343..345; 353..356; 362..364; 367..369; 376..380; 390..392; 414..416; 428..430; 433..435; 447..449; 469..472; 495..497; 518..520; 540..542; 565..567; 575..577; 587..590

3D Structure

Electron microscopy (5); X-ray crystallography (1)

Domain & Motif Annotations

Repeat

50..73; LRR 1; 74..95; LRR 2; 98..119; LRR 3; 125..145; LRR 4; 150..171; LRR 5; 174..195; LRR 6; 198..219; LRR 7; 220..240; LRR 8; 244..265; LRR 9; 266..286; LRR 10; 316..339; LRR 11; 340..363; LRR 12; 364..385; LRR 13; 387..408; LRR 14; 411..432; LRR 15; 444..465; LRR 16; 467..488; LRR 17; 492..513; LRR 18; 515..536; LRR 19; 537..558; LRR 20

Domain (FT)

21..48; LRRNT; 571..620; LRRCT

Protein Families

LRRC32/LRRC33 family

Sequence Similarities

Belongs to the LRRC32/LRRC33 family.

Clinical Relevance

Related Diseases

Solid tumour/cancer

Biomarker

Phase 1

Drugs (5)

QUISINOSTAT KA1010 SS-208 FIMEPINOSTAT VORINOSTAT

Supporting Publications4

PMID	Title	Related sentences
28963552	Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No related sentences available
40928027	Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.	No related sentences available