Protein detail
GP176
G-protein coupled receptor 176 (HB-954)
Entry name GP176 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
G-protein coupled receptor 176 (HB-954)
Protein Class (2)
G-protein coupled receptorsPredicted membrane proteins
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
43..63; Helical; Name=1; 83..103; Helical; Name=2; 119..139; Helical; Name=3; 161..181; Helical; Name=4; 208..228; Helical; Name=5; 268..288; Helical; Name=6; 300..320; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
Gm1012
Gene Description
G protein-coupled receptor 176
Chromosome
15
Position
39799008-39920266
Supporting publications (n)
2
EVMP confidence score
0.25
Function & Pathway6
Protein Function
G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function
Biological Process (3)
Mediation Categories
Receptor-signaling mediation
Relations & Evidence38
Ligand-Receptor Signaling (37)
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpcr | receptor | Surfaceome | No | Yes | No | Yes | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_orphan | receptor | GPCRdb | No | Yes | No | Yes | No |
| class_a_rhodopsin_orphan_class_a_orphans | receptor | GPCRdb | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryR Sequencing | 1 | 32390047 |
Sequence, Structure & Domains9
Sequences
Length
515
Mass
56,998
Sequence
MGHNGSWISPNASEPHNASGAEAAGVNRSALGEFGEAQLYRQFTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWWIYTMLFCKVVKFLHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCLIGTLVQLHHRYSRRNVVSTGSGMAEASLEPSIRSGSQLLEMFHIGQQQIFKPTEDEEESEAKYIGSADFQAKEIFSTCLEGEQGPQFAPSAPPLSTVDSVSQVAPAAPVEPETFPDKYSLQFGFGPFELPPQWLSETRNSKKRLLPPLGNTPEELIQTKVPKVGRVERKMSRNNKVSIFPKVDS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14439-1; Sequence=Displayed; Name=2; IsoId=Q14439-2; Sequence=VSP_058845; Name=3; IsoId=Q14439-3; Sequence=VSP_058846
Alternative Sequence
1..56; MGHNGSWISPNASEPHNASGAEAAGVNRSALGEFGEAQLYRQFTTTVQVVIFIGSL -> MPAPLLLISRT (in isoform 2); 58..78; GNFMVLWSTCRTTVFKSVTNR -> EFGNMEVTRKLDKSRLPGIK (in isoform 3)
Domain & Motif Annotations
Compositional Bias
1..16; Polar residues
Region
1..20; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.