Protein detail
S29A2
Equilibrative nucleoside transporter 2 (hENT2) (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)
Entry name S29A2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 11 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Equilibrative nucleoside transporter 2 (hENT2) (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)
Protein Class (3)
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
13..33; Helical; 70..90; Helical; 99..119; Helical; 124..144; Helical; 162..182; Helical; 193..213; Helical; 291..311; Helical; 324..344; Helical; 360..380; Helical; 386..406; Helical; 432..452; Helical
Transmembrane Count
11
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
DER12ENT2HNP36
Gene Description
Solute carrier family 29 member 2
Chromosome
11
Position
66362521-66372214
EVMP confidence score
0.38
Function & Pathway7
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (4)
Molecular Function (9)
- GO:0005326 neurotransmitter transmembrane transporter activity
- GO:0005337 nucleoside transmembrane transporter activity
- GO:0015205 nucleobase transmembrane transporter activity
- GO:0015207 adenine transmembrane transporter activity
- GO:0015208 guanine transmembrane transporter activity
- GO:0015210 uracil transmembrane transporter activity
- GO:0015211 purine nucleoside transmembrane transporter activity
- GO:0015212 cytidine transmembrane transporter activity
- GO:0015213 uridine transmembrane transporter activity
Biological Process (3)
Reactome (6)
- R-hsa-9748787 azathioprine adme
- R-hsa-9748784 drug adme
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-83936 transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
- R-hsa-382551 transport of small molecules
- R-hsa-425397 transport of vitamins nucleosides and related molecules
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence36
Ligand-Receptor Signaling (34)
34 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| basolateral_cell_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Ramilowski_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32396726 |
Sequence, Structure & Domains7
Sequences
Length
456
Mass
50,113
Sequence
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTGPEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAELLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLVFTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long; IsoId=Q14542-1; Sequence=Displayed; Name=2; Synonyms=Short, HNP36; IsoId=Q14542-2; Sequence=VSP_040728, VSP_040729; Name=3; Synonyms=hENT2A; IsoId=Q14542-3; Sequence=VSP_040730, VSP_040731; Name=4; IsoId=Q14542-4; Sequence=VSP_061920
Alternative Sequence
93..202; VPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVG -> AGQGGHEPRTLLLHHHGLRLLHQLLQCSPTGQPLRAAGHHALHLQHPLPQRPGPGWDLCCPCHAPVHGQWRGRRDLCPGVLYHALCGHPHVHRVLPEPASPEVCPLLPGQ (in isoform 2); 203..456; Missing (in isoform 2); 246..456; ENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLVFTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL -> LADSAVPCVGLHSHPVRLPRHHSHGDQLHQSWEVESVLQPHLLLPPLQHHGLAGTEPDLLLPVARRGQPAAAPAGLPAVPVRAPLHAVPRAPEVPAAHPLPTGCLLHHLHAALCRF (in isoform 4); 290..301; IWLTALCLVLVF -> SPCPSSPPSQPW (in isoform 3); 302..456; Missing (in isoform 3)
Domain & Motif Annotations
Protein Families
SLC29A/ENT transporter (TC 2.A.57) family
Sequence Similarities
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Clinical Relevance2
Antibody