Protein detail
DSC3
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Entry name DSC3 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 11 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Protein Class (4)
Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function (2)
- Disease related genes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
Transmembrane
691..711; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CDHF3 DSC4
Gene Description
Desmocollin 3
Chromosome
18
Position
30989365-31042815
Supporting publications (n)
11
EVMP confidence score
0.60
Fluorescence & Localization3
Tissue SpecifickidneyCell SpecificConjunctival goblet cellsSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway8
Protein Function (2)
- Disease related genes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
Cellular Component (8)
Molecular Function (2)
Biological Process (3)
Canonical Pathways (3)
- M269 Pid ras pathway
- M240 Pid syndecan 2 pathway
- M106 Pid hnf3b pathway
Mediation Categories (2)
Adhesion and uptake mediationImmune mediation
Relations & Evidence49
Ligand-Receptor Signaling (48)
48 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| ecm | ecm | MatrixDB | Yes | No | No | Yes | No |
| ecm | ecm | OmniPath | Yes | No | No | Yes | No |
| extracellular | extracellular | LOCATE | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32396726 |
Sequence, Structure & Domains7
Sequences
Length
896
Mass
99,969
Sequence
MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=3A; IsoId=Q14574-1; Sequence=Displayed; Name=3B; IsoId=Q14574-2; Sequence=VSP_000663, VSP_000664
Alternative Sequence
832..839; KLHRCNQN -> ESIRGHTG (in isoform 3B); 840..896; Missing (in isoform 3B)
Domain & Motif Annotations
Domain (CC)
Calcium may be bound by the cadherin-like repeats.; DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
136..243; Cadherin 1; 244..355; Cadherin 2; 356..471; Cadherin 3; 472..579; Cadherin 4; 580..690; Cadherin 5
Clinical Relevance3
Disease Involvement
Hypotrichosis
Supporting Publications11
| PMID | Title | Abstract |
|---|---|---|
| 33799461 | Proteomics Profiling of Neuron-Derived Small Extracellular Vesicles from Human Plasma: Enabling Single-Subject Analysis. | No abstract available |
| 36573687 | Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes. | No abstract available |
| 37403840 | Phosphoproteome analysis of cerebrospinal fluid extracellular vesicles in primary central nervous system lymphoma. | No abstract available |
| 37438638 | Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy. | No abstract available |
| 38871114 | Proteomic analysis of endothelial cells and extracellular vesicles in response to indoxyl sulfate: Mechanisms of endothelial dysfunction in chronic kidney disease. | No abstract available |
| 39408670 | Proteomic Characterization of Corneal Epithelial and Stromal Cell-Derived Extracellular Vesicles. | No abstract available |
| 39535266 | Divergent Proteomic Profiles and Uptake Mechanisms of Exosomes Derived from Human Dental Pulp Stem Cells, Endothelial Cells, and Fibroblasts. | No abstract available |
| 39778061 | Proteomic Analysis of Plasma Exosomes Enables the Identification of Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease. | No abstract available |
| 39996590 | Surface Double Dendritic Magnetic Microfibrils for Rapid Isolation and Proteomic Profiling of Extracellular Vesicles from Microliters of Biofluids. | No abstract available |
| 40596376 | Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients. | No abstract available |
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