Protein detail
DSC3
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Entry name DSC3 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 11 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Protein Class (4)
Disease related genesHuman disease related genesPlasma proteinsPredicted membrane proteins
Protein Function (2)
- Disease related genes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
Transmembrane
691..711; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CDHF3 DSC4
Gene Description
Desmocollin 3
Chromosome
18
Position
30989365-31042815
Supporting publications (n)
11
EVMP confidence score
0.60
Fluorescence & Localization3
Tissue SpecifickidneyCell SpecificConjunctival goblet cellsSingle-Nuclei Brain Specificcerebellar inhibitory
Function & Pathway8
Protein Function (2)
- Disease related genes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
Cellular Component (8)
Molecular Function (2)
Biological Process (3)
Canonical Pathways (3)
- M269 Pid ras pathway
- M240 Pid syndecan 2 pathway
- M106 Pid hnf3b pathway
Mediation Categories (2)
Adhesion and uptake mediationImmune mediation
Relations & Evidence49
Ligand-Receptor Signaling (48)
48 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| desmosomal_cadherin | cell_adhesion | Almen2009 | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Almen2009 | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Zhong2015 | No | Yes | No | Yes | No |
| focal_adhesion | matrix_adhesion | Zhong2015 | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32396726 |
Sequence, Structure & Domains7
Sequences
Length
896
Mass
99,969
Sequence
MAAAGPRRSVRGAVCLHLLLTLVIFSRAGEACKKVILNVPSKLEADKIIGRVNLEECFRSADLIRSSDPDFRVLNDGSVYTARAVALSDKKRSFTIWLSDKRKQTQKEVTVLLEHQKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIRVEDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHTRLKYSILQQTPRSPGLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFVEENAFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVGSKINGYKAYDPENRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYNITVLAIDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEPKFITLAEACTKR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=3A; IsoId=Q14574-1; Sequence=Displayed; Name=3B; IsoId=Q14574-2; Sequence=VSP_000663, VSP_000664
Alternative Sequence
832..839; KLHRCNQN -> ESIRGHTG (in isoform 3B); 840..896; Missing (in isoform 3B)
Domain & Motif Annotations
Domain (CC)
Calcium may be bound by the cadherin-like repeats.; DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
136..243; Cadherin 1; 244..355; Cadherin 2; 356..471; Cadherin 3; 472..579; Cadherin 4; 580..690; Cadherin 5
Clinical Relevance3
Disease Involvement
Hypotrichosis