Protein detail
I11RA
Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
Entry name I11RA | UniProt ID | EVMP score 0.38 |
Frequency 3 | Transmembrane count 1 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Disease related genes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Other congenital malformations
- FDA approved drug targets:Biotech drugs
Transmembrane
371..391; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Interleukin 11 receptor subunit alpha
Chromosome
9
Position
34652162-34661902
Frequency
3
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificoligodendrocyte precursor cell
Function & Pathway
Protein Function
- Disease related genes
- Predicted secreted proteins
- Human disease related genes:Congenital malformations:Other congenital malformations
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
M175 Pid erbb2 erbb3 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
66 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Baccin2019 | No | Yes | Yes | Yes | No |
| receptor | receptor | SignaLink_function | No | Yes | Yes | Yes | No |
| cytokine | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| ig_like | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| type1_ig_like_cytokine | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| cytokine_receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| interleukin | receptor | Baccin2019 | No | Yes | Yes | Yes | No |
| cytokine_type_1 | receptor | HPMR | No | Yes | Yes | Yes | No |
| cicytr_cytokine_type_1 | receptor | HPMR | No | Yes | Yes | Yes | No |
| ig | receptor | Surfaceome | No | Yes | Yes | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IL11 | P20809 | I11RA | Q14626 | Yes | Yes | No | iTALKKirouac2010SIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb | LRdb:10504396Baccin2019:10948192LRdb:10948192SIGNOR:10948192LRdb:7670098HINT:8940087Lit-BM-17:26551460HPRD:7670098InnateDB:8940087HINT:26551460Baccin2019:10504396HPRD:10504396DIP:8940087Lit-BM-17:8940087SignaLink3:23331499Baccin2019:7670098HINT:37985757connectomeDB2020:10948192SignaLink3:12740032CellTalkDB:10948192connectomeDB2020:10504396connectomeDB2020:7670098HPMR:10948192SPIKE_LC:16189514 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
422
Mass
45,222
Sequence
MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHRDSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAPNL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=HCR1; Synonyms=Membrane form, mIL11RA; IsoId=Q14626-1; Sequence=Displayed; Name=HCR2; Synonyms=Soluble form, sIL11RA; IsoId=Q14626-2; Sequence=VSP_011879
Alternative Sequence
391..422; Missing (in isoform HCR2)
3D Structural Models
Turn
86..88
Helix
212..215
Beta Strand
30..32; 35..38; 44..47; 57..61; 73..75; 78..83; 90..99; 101..109; 117..133; 139..141; 143..150; 178..183; 191..199; 204..210; 222..228; 236..241; 254..264; 269..271; 277..280; 289..297; 311..313
3D Structure
Electron microscopy (3); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
413..422; Basic and acidic residues
Motif
304..308; WSXWS motif
Domain (FT)
27..110; Ig-like C2-type; 112..219; Fibronectin type-III 1; 220..317; Fibronectin type-III 2
Region
335..355; Disordered; 398..422; Disordered
Protein Families
- Type I cytokine receptor family
- Type 3 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 3 subfamily.
Clinical Relevance
Disease Involvement
CraniosynostosisDisease variantFDA approved drug targets
Related Diseases
Biomarker
Phase 1; Approved
Drug Targets
FDA approved drug targets