Protein detail

I11RA

Interleukin-11 receptor subunit alpha (IL-11 receptor subunit alpha) (IL-11R subunit alpha) (IL-11R-alpha) (IL-11RA) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]

Entry name I11RA	UniProt ID Q14626	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count 1	Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Protein Class (5)

Disease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteinsPredicted secreted proteins

Protein Function (4)

Disease related genes
Predicted secreted proteins
Human disease related genes:Congenital malformations:Other congenital malformations
FDA approved drug targets:Biotech drugs

Transmembrane

371..391; Helical

Transmembrane Count

Ensembl

ENSG00000137070

Entrez Gene Symbol

IL11RA

Gene Description

Interleukin 11 receptor subunit alpha

Chromosome

Position

34652162-34661902

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue SpecificbrainCell SpecificAstrocytesSingle-Nuclei Brain Specificoligodendrocyte precursor cell

Function & Pathway8

Protein Function (4)

Disease related genes
Predicted secreted proteins
Human disease related genes:Congenital malformations:Other congenital malformations
FDA approved drug targets:Biotech drugs

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG (3)

Reactome (4)

Canonical Pathways

M175 Pid erbb2 erbb3 pathway

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence69

Ligand-Receptor Signaling (66)

66 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ligand	ligand	Cellinker	Yes	No	Yes	Yes	No
ligand	ligand	OmniPath	Yes	No	Yes	Yes	No
receptor	receptor	talklr	No	Yes	Yes	Yes	No
receptor	receptor	scConnect	No	Yes	Yes	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	Yes	Yes	No
receptor	receptor	CellCall	No	Yes	Yes	Yes	No
receptor	receptor	iTALK	No	Yes	Yes	Yes	No
cytokine	receptor	iTALK	No	Yes	Yes	Yes	No
receptor	receptor	Almen2009	No	Yes	Yes	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	Yes	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL11	P20809	I11RA	Q14626	Yes	Yes	No	iTALKKirouac2010SIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	LRdb:10504396 Baccin2019:10948192 LRdb:10948192 SIGNOR:10948192 LRdb:7670098 HINT:8940087 Lit-BM-17:26551460 HPRD:7670098 InnateDB:8940087 HINT:26551460 Baccin2019:10504396 HPRD:10504396 DIP:8940087 Lit-BM-17:8940087 SignaLink3:23331499 Baccin2019:7670098 HINT:37985757 connectomeDB2020:10948192 SignaLink3:12740032 CellTalkDB:10948192 connectomeDB2020:10504396 connectomeDB2020:7670098 HPMR:10948192 SPIKE_LC:16189514

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IL11RA	Q14626	2	PDB	PDB:6o4p

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38716512

Sequence, Structure & Domains15

Sequences

Length

422

Mass

45,222

Sequence

MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHRDSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAPNL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=HCR1; Synonyms=Membrane form, mIL11RA; IsoId=Q14626-1; Sequence=Displayed; Name=HCR2; Synonyms=Soluble form, sIL11RA; IsoId=Q14626-2; Sequence=VSP_011879

Alternative Sequence

391..422; Missing (in isoform HCR2)

3D Structural Models

Turn

86..88

Helix

212..215

Beta Strand

30..32; 35..38; 44..47; 57..61; 73..75; 78..83; 90..99; 101..109; 117..133; 139..141; 143..150; 178..183; 191..199; 204..210; 222..228; 236..241; 254..264; 269..271; 277..280; 289..297; 311..313

3D Structure

Electron microscopy (3); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

413..422; Basic and acidic residues

Motif

304..308; WSXWS motif

Domain (FT)

27..110; Ig-like C2-type; 112..219; Fibronectin type-III 1; 220..317; Fibronectin type-III 2

Region

335..355; Disordered; 398..422; Disordered

Protein Families (2)

Type I cytokine receptor family
Type 3 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Clinical Relevance6

Disease Involvement (3)

CraniosynostosisDisease variantFDA approved drug targets

Related Diseases (2)

Prostate cancer Thrombocytopenia

Biomarker

Phase 1; Approved

Drug Targets

FDA approved drug targets

Drugs (2)

INTERLEUKIN-11 BONE METASTASIS TARGETING PEPTIDE-11

Antibody (4)

HPA013162 CAB032830 HPA036652 HPA036653

Supporting Publications3

PMID	Title	Abstract
29689087	Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes.	To assess the involvement of these RBPs in RNA-transfer into exosomes, the gene transcripts encoding six of the proteins identified in exosomes (HSP90AB1, XPO5, hnRNPH1, hnRNPM, hnRNPA2B1, and MVP) were silenced by siRNA and subsequent effect on esRNA was assessed.
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
32841894	Insight into the proteomic profiling of exosomes secreted by human OM-MSCs reveals a new potential therapy.	A total of 304 exosome-associated proteins were identified by LC-MS/MS, including plasminogen activator inhibitor 1 (SERPINE 1), insulin-like growth factor binding protein family members (IGFBP 4 and 5), epidermal growth factor receptor (EGFR), neurogenic locus notch homolog protein 2 (NOTCH 2), apolipoprotein E (APOE), and heat shock protein HSP90-beta (HSP90AB1). Similar to other exosomes, OM-MSC exosomes were CD63- and CD81-positive and calnexin-negative.