Protein detail

I13R2

Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)

Protein symbol I13R2	UniProt ID Q14627	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers

Transmembrane

344..363; Helical

Transmembrane Count

Ensembl

ENSG00000123496

Entrez Gene Symbol

IL13RA2

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificbrainCell SpecificBergmann gliaSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion

Function & Pathway

Protein Function

Cancer-related genes:Candidate cancer biomarkers
CD markers

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

62 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	SignaLink_function	No	Yes	No	Yes	No
cytokine	receptor	Almen2009	No	Yes	No	Yes	No
ig_like	receptor	Almen2009	No	Yes	No	Yes	No
type1_ig_like_cytokine	receptor	Almen2009	No	Yes	No	Yes	No
cytokine_receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
interleukin	receptor	Baccin2019	No	Yes	No	Yes	No
cytokine_type_1	receptor	HPMR	No	Yes	No	Yes	No
il2rg_cytokine_type_1	receptor	HPMR	No	Yes	No	Yes	No
ig	receptor	Surfaceome	No	Yes	No	Yes	No
type1	receptor	Surfaceome	No	Yes	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL13	P35225	I13R2	Q14627	Yes	Yes	No	iTALKICELLNETHINTSignaLink3InnateDBDIPUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbInnateDB_SignaLink3talklrHPRDCui2007IntActDLRP_talklrRamilowski2015_Baccin2019WangACSN_SignaLink3Ramilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019STRING_talklrCellCallCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	ICELLNET:8663118 DIP:20223216 SignaLink3:20184663 CellTalkDB:26471366 connectomeDB2020:12704343 connectomeDB2020:11003391 SignaLink3:18451175 SignaLink3:12401408 IntAct:20223216 HINT:8663118LRdb:11HPMR:12704343 IntAct:27629921 SignaLink3:12223527 SignaLink3:21097505 HINT:11313257 SignaLink3:14657224Baccin2019:1270434311003390SignaLink3:26192618 SignaLink3:26755705 SignaLink3:18250477 HINT:11003391 SignaLink3:9535722 HINT:20223216 SignaLink3:14985454 SignaLink3:23331499 DIP:8663118 HINT:27629921 SignaLink3:8663118 HPRD:11003391 HINT:23972995 LRdb:12704343 InnateDB:8663118 SignaLink3:14610620 SignaLink3:23180781 HINT:22952195 SignaLink3:15099563 IntAct:23972995

Protein Complex Composition

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Chitinase 3-like-1-tmem219-interleukin-13 receptor-ligand alpha-2 signalling complex	CHI3L1 IL13 IL13RA2 TMEM219	P35225 P36222 Q14627 Q86XT9	1:1:1:1	ComplexPortal		32402213 32929074 27629921 36152905 38177294 14755292 23972995
TMEM219-Interleukin-13 decoy-receptor-ligand alpha 2 complex	IL13 IL13RA2 TMEM219	P35225 Q14627 Q86XT9	1:1:1	ComplexPortal	PDB:3LB6	32037147 35464460 20223216 12642602 31974500 14755292 31230370
	IL13 IL13RA2	P35225 Q14627	2:2	PDB	PDB:3lb6
	IL13RA2 TSHZ3 UCP2	P55851 Q14627 Q63HK5	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32396726

Sequence, Structure & Domains

Sequences

Length

380

Mass

44,176

Sequence

MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLDHFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQSSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDHALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTGLLLRKPNTYPKMIPEFFCDT

3D Structural Models

Turn

149..151; 314..316

Helix

111..114; 232..234

Beta Strand

36..41; 44..54; 68..75; 82..94; 101..108; 115..117; 126..128; 141..148; 152..158; 168..174; 185..189; 194..198; 206..208; 210..217; 226..230; 235..237; 242..246; 256..259; 262..264; 270..274; 287..291; 308..312

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Motif

322..326; WSXWS motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The cytoplasmic domain functions as an inhibitor of IL-4 or IL-13-dependent activation of the Jak-Stat pathway (PubMed:11861389).

Domain (FT)

34..134; Fibronectin type-III 1; 139..235; Fibronectin type-III 2; 240..333; Fibronectin type-III 3

Protein Families

Type I cytokine receptor family
Type 5 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Clinical Relevance

Related Diseases

Asthma Brain cancer Oesophagitis

Biomarker

Phase 1; Phase 3; Phase 2

Drugs

CINTREDEKIN BESUDOTOX NULL CENDAKIMAB TRALOKINUMAB MULTI-GLIOBLASTOMA-PEPTIDE-TARGETING AUTOLOGOUS DENDRITIC CELL VACCINE ICT-107

Interaction Protein

ENSG00000169194

Interaction Count

Interaction Dataset

intact_biogrid