Protein detail

I13R2

Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)

Entry name I13R2	UniProt ID Q14627	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Interleukin-13 receptor subunit alpha-2 (IL-13 receptor subunit alpha-2) (IL-13R subunit alpha-2) (IL-13R-alpha-2) (IL-13RA2) (Interleukin-13-binding protein) (CD antigen CD213a2)

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
CD markers

Transmembrane

344..363; Helical

Transmembrane Count

Ensembl

ENSG00000123496

Entrez Gene Symbol

IL13RA2

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificBergmann gliaSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion

Function & Pathway7

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
CD markers

Cellular Component (4)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (3)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence68

Ligand-Receptor Signaling (62)

62 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL13	P35225	I13R2	Q14627	Yes	Yes	No	iTALKICELLNETHINTSignaLink3InnateDBDIPUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbInnateDB_SignaLink3talklrHPRDCui2007IntActDLRP_talklrRamilowski2015_Baccin2019WangACSN_SignaLink3Ramilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019STRING_talklrCellCallCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	ICELLNET:8663118 DIP:20223216 SignaLink3:20184663 CellTalkDB:26471366 connectomeDB2020:12704343 connectomeDB2020:11003391 SignaLink3:18451175 SignaLink3:12401408 IntAct:20223216 HINT:8663118LRdb:11HPMR:12704343 IntAct:27629921 SignaLink3:12223527 SignaLink3:21097505 HINT:11313257 SignaLink3:14657224Baccin2019:1270434311003390SignaLink3:26192618 SignaLink3:26755705 SignaLink3:18250477 HINT:11003391 SignaLink3:9535722 HINT:20223216 SignaLink3:14985454 SignaLink3:23331499 DIP:8663118 HINT:27629921 SignaLink3:8663118 HPRD:11003391 HINT:23972995 LRdb:12704343 InnateDB:8663118 SignaLink3:14610620 SignaLink3:23180781 HINT:22952195 SignaLink3:15099563 IntAct:23972995

Protein Complex Composition (4)

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Chitinase 3-like-1-tmem219-interleukin-13 receptor-ligand alpha-2 signalling complex	CHI3L1 IL13 IL13RA2 TMEM219	P35225 P36222 Q14627 Q86XT9	1:1:1:1	ComplexPortal		32402213 32929074 27629921 36152905 38177294 14755292 23972995
TMEM219-Interleukin-13 decoy-receptor-ligand alpha 2 complex	IL13 IL13RA2 TMEM219	P35225 Q14627 Q86XT9	1:1:1	ComplexPortal	PDB:3LB6	32037147 35464460 20223216 12642602 31974500 14755292 31230370
	IL13 IL13RA2	P35225 Q14627	2:2	PDB	PDB:3lb6
	IL13RA2 TSHZ3 UCP2	P55851 Q14627 Q63HK5	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32396726

Sequence, Structure & Domains12

Sequences

Length

380

Mass

44,176

Sequence

MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLDHFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQSSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDHALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTGLLLRKPNTYPKMIPEFFCDT

3D Structural Models

Turn

149..151; 314..316

Helix

111..114; 232..234

Beta Strand

36..41; 44..54; 68..75; 82..94; 101..108; 115..117; 126..128; 141..148; 152..158; 168..174; 185..189; 194..198; 206..208; 210..217; 226..230; 235..237; 242..246; 256..259; 262..264; 270..274; 287..291; 308..312

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Motif

322..326; WSXWS motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The cytoplasmic domain functions as an inhibitor of IL-4 or IL-13-dependent activation of the Jak-Stat pathway (PubMed:11861389).

Domain (FT)

34..134; Fibronectin type-III 1; 139..235; Fibronectin type-III 2; 240..333; Fibronectin type-III 3

Protein Families (2)

Type I cytokine receptor family
Type 5 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Clinical Relevance6

Related Diseases (3)

Asthma Brain cancer Oesophagitis

Biomarker

Phase 1; Phase 3; Phase 2

Drugs (5)

CINTREDEKIN BESUDOTOX NULL CENDAKIMAB TRALOKINUMAB MULTI-GLIOBLASTOMA-PEPTIDE-TARGETING AUTOLOGOUS DENDRITIC CELL VACCINE ICT-107

Interaction Protein

ENSG00000169194

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available