Protein detail
PLSI
Plastin-1 (Intestine-specific plastin) (I-plastin)
Entry name PLSI | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Plastin-1 (Intestine-specific plastin) (I-plastin)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Ear disease
Ensembl
Entrez Gene Symbol
Gene Description
Plastin 1
Chromosome
3
Position
142596393-142713664
Supporting publications (n)
2
EVMP confidence score
0.40
Function & Pathway
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (9)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Canonical Pathways (3)
- M83 Pid cdc42 reg pathway
- M177 Pid epha fwdpathway
- M241 Pid rac1 reg pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence8
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | ||||
| ecm | ecm | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (1)
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ARF6LSM1LSM3LSM4LSM5LSM6LSM7LSM8PLS1PRPF3PRPF4SART3SNRPD3TXNL4AUBC | O15116O43172O43395O95777P0CG48P62310P62312P62318P62330P83876Q14651Q15020Q9UK45Q9Y4Y9Q9Y4Z0 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4980 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32396726 |
Sequence, Structure & Domains
Sequences
Length
629
Mass
70,253
Sequence
MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILSVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGKGLNRIK
Domain & Motif Annotations
Domain (FT)
11..46; EF-hand 1; 51..86; EF-hand 2; 122..238; Calponin-homology (CH) 1; 266..376; Calponin-homology (CH) 2; 395..504; Calponin-homology (CH) 3; 516..625; Calponin-homology (CH) 4
Region
108..380; Actin-binding 1; 381..625; Actin-binding 2
Clinical Relevance
Disease Involvement (3)
DeafnessDisease variantNon-syndromic deafness
Related Diseases (2)
Interaction Protein
ENSG00000102024
Interaction Count
1
Interaction Dataset
biogrid_bioplex
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 36573687 | Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes. | No related sentences available |
| 40596376 | Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients. | No related sentences available |