Protein detail
PLSI
Plastin-1 (Intestine-specific plastin) (I-plastin)
Entry name PLSI | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Plastin-1 (Intestine-specific plastin) (I-plastin)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Ear disease
Ensembl
Entrez Gene Symbol
Gene Description
Plastin 1
Chromosome
3
Position
142596393-142713664
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M83 Pid cdc42 reg pathway
- M177 Pid epha fwdpathway
- M241 Pid rac1 reg pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
1 record.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ARF6LSM1LSM3LSM4LSM5LSM6LSM7LSM8PLS1PRPF3PRPF4SART3SNRPD3TXNL4AUBC | O15116O43172O43395O95777P0CG48P62310P62312P62318P62330P83876Q14651Q15020Q9UK45Q9Y4Y9Q9Y4Z0 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4980 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32396726 |
Sequence, Structure & Domains
Sequences
Length
629
Mass
70,253
Sequence
MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILSVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGKGLNRIK
3D Structural Models
Domain & Motif Annotations
Domain (FT)
11..46; EF-hand 1; 51..86; EF-hand 2; 122..238; Calponin-homology (CH) 1; 266..376; Calponin-homology (CH) 2; 395..504; Calponin-homology (CH) 3; 516..625; Calponin-homology (CH) 4
Region
108..380; Actin-binding 1; 381..625; Actin-binding 2