Protein detail

PLSI

Plastin-1 (Intestine-specific plastin) (I-plastin)

Entry name PLSI	UniProt ID Q14651	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Plastin-1 (Intestine-specific plastin) (I-plastin)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Ear disease

Ensembl

ENSG00000120756

Entrez Gene Symbol

PLS1

Gene Description

Plastin 1

Chromosome

Position

142596393-142713664

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway7

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Ear disease

Cellular Component (9)

Molecular Function (3)

Biological Process (3)

Reactome (3)

Canonical Pathways (3)

M83 Pid cdc42 reg pathway
M177 Pid epha fwdpathway
M241 Pid rac1 reg pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence8

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	GO_Intercell	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARF6 LSM1 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 PLS1 PRPF3 PRPF4 SART3 SNRPD3 TXNL4A UBC	O15116 O43172 O43395 O95777 P0CG48 P62310 P62312 P62318 P62330 P83876 Q14651 Q15020 Q9UK45 Q9Y4Y9 Q9Y4Z0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4980

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32396726

Sequence, Structure & Domains5

Sequences

Length

629

Mass

70,253

Sequence

MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILSVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGKGLNRIK

Domain & Motif Annotations

Domain (FT)

11..46; EF-hand 1; 51..86; EF-hand 2; 122..238; Calponin-homology (CH) 1; 266..376; Calponin-homology (CH) 2; 395..504; Calponin-homology (CH) 3; 516..625; Calponin-homology (CH) 4

Region

108..380; Actin-binding 1; 381..625; Actin-binding 2

Clinical Relevance5

Disease Involvement (3)

DeafnessDisease variantNon-syndromic deafness

Antibody (3)

HPA000895 HPA055744 HPA061936

Interaction Protein

ENSG00000102024

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications2

PMID	Title	Abstract
36573687	Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes.	No abstract available
40596376	Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients.	No abstract available