Protein detail

KANK1

KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)

Entry name KANK1	UniProt ID Q14678	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins

Ensembl

ENSG00000107104

Entrez Gene Symbol

KANK1

Gene Synonym (3)

ANKRD15KANKKIAA0172

Gene Description

KN motif and ankyrin repeat domains 1

Chromosome

Position

470291-746105

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificExtravillous trophoblastsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway7

Protein Function (3)

Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Reactome (6)

Canonical Pathways (2)

M92 Pid angiopoietin receptor pathway
M281 Pid fak pathway

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence13

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KANK1	Q14678	BAIP2	Q9UQB8	Yes	No	Yes	HPRDSIGNORIntAct	HPRD:19171758 SIGNOR:19171758 IntAct:19171758

Protein Complex Composition (6)

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
DYNLL1 FAM117B KANK1 KIF21A	P63167 Q14678 Q6P1L5 Q7Z4S6	0:0:0:0	hu.MAP
DYNLL1 DYNLL2 KANK1 KIF21A	P63167 Q14678 Q7Z4S6 Q96FJ2	0:0:0:0	hu.MAP
DYNLL1 KANK1 KIF21A TLK1	P63167 Q14678 Q7Z4S6 Q9UKI8	0:0:0:0	hu.MAP
DYNLL1 FBXO30 KANK1	P63167 Q14678 Q8TB52	0:0:0	hu.MAP2
KANK1	Q14678	4	PDB	PDB:8iw0
KANK1 KIF21A	Q14678 Q7Z4S6	1:1	hu.MAPPDB	PDB:5ybu

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	2	38731868 37922300

Sequence, Structure & Domains14

Sequences

Length

1,352

Mass

147,289

Sequence

MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGTSVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVCETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEAAVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD

Alternative Products

Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=Kank-L; IsoId=Q14678-1; Sequence=Displayed; Name=2; Synonyms=Kank-S; IsoId=Q14678-2; Sequence=VSP_043958

Alternative Sequence

1..158; Missing (in isoform 2)

3D Structural Models

Turn

1231..1234

Helix

36..38; 44..53; 1087..1099; 1103..1106; 1109..1126; 1133..1146; 1148..1155; 1165..1171; 1175..1183; 1199..1205; 1211..1223; 1237..1243; 1247..1255; 1270..1277; 1280..1287; 1304..1310; 1314..1324

Beta Strand

32..34; 40..42

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias

1..11; Polar residues; 22..31; Basic and acidic residues; 77..86; Polar residues; 87..97; Low complexity; 914..925; Low complexity; 979..989; Basic and acidic residues; 1008..1019; Low complexity

Repeat

1109..1146; ANK 0; degenerate; 1161..1191; ANK 1; 1195..1228; ANK 2; 1233..1262; ANK 3; 1266..1298; ANK 4; 1300..1329; ANK 5

Motif

41..44; Important for binding to TLN1; 43..52; Nuclear export signal 1 (NES 1); 65..68; Nuclear localization signal 1 (NLS 1); 125..134; Nuclear export signal 2 (NES 2); 613..622; Nuclear export signal 3 (NES 3); 979..992; Nuclear localization signal 2 (NLS 2)

Coiled Coil

258..316; 361..395; 446..500

Region

1..31; Disordered; 30..68; KN motif; Interaction with TLN1; 63..103; Disordered; 244..339; Interaction with PPFIBP1; 914..951; Disordered; 979..1026; Disordered; 1073..1352; Interaction with KIF21A; 1331..1352; Disordered

Clinical Relevance5

Disease Involvement

Tumor suppressor

Antibody (2)

HPA005539 HPA056090

Interaction Protein (3)

ENSG00000088986ENSG00000134308ENSG00000264364

Interaction Count

Interaction Dataset (2)

biogrid_opencellintact_biogrid

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available