Protein detail
KANK1
KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)
Entry name KANK1 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ANKRD15KANKKIAA0172
Gene Description
KN motif and ankyrin repeat domains 1
Chromosome
9
Position
470291-746105
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificExtravillous trophoblastsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-8939211 esr mediated signaling
- R-hsa-9018519 estrogen dependent gene expression
- R-hsa-9673768 signaling by membrane tethered fusions of pdgfra or pdgfrb
- R-hsa-9006931 signaling by nuclear receptors
- R-hsa-9671555 signaling by pdgfr in disease
Canonical Pathways
- M92 Pid angiopoietin receptor pathway
- M281 Pid fak pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KANK1 | Q14678 | BAIP2 | Q9UQB8 | Yes | No | Yes | HPRDSIGNORIntAct | HPRD:19171758SIGNOR:19171758IntAct:19171758 |
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DYNLL1FAM117BKANK1KIF21A | P63167Q14678Q6P1L5Q7Z4S6 | 0:0:0:0 | hu.MAP | |||
| DYNLL1DYNLL2KANK1KIF21A | P63167Q14678Q7Z4S6Q96FJ2 | 0:0:0:0 | hu.MAP | |||
| DYNLL1KANK1KIF21ATLK1 | P63167Q14678Q7Z4S6Q9UKI8 | 0:0:0:0 | hu.MAP | |||
| DYNLL1FBXO30KANK1 | P63167Q14678Q8TB52 | 0:0:0 | hu.MAP2 | |||
| KANK1 | Q14678 | 4 | PDB | PDB:8iw0 | ||
| KANK1KIF21A | Q14678Q7Z4S6 | 1:1 | hu.MAPPDB | PDB:5ybu |
Sequence, Structure & Domains
Sequences
Length
1,352
Mass
147,289
Sequence
MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGTSVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVCETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEAAVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD
Alternative Products
Event=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=Kank-L; IsoId=Q14678-1; Sequence=Displayed; Name=2; Synonyms=Kank-S; IsoId=Q14678-2; Sequence=VSP_043958
Alternative Sequence
1..158; Missing (in isoform 2)
3D Structural Models
Turn
1231..1234
Helix
36..38; 44..53; 1087..1099; 1103..1106; 1109..1126; 1133..1146; 1148..1155; 1165..1171; 1175..1183; 1199..1205; 1211..1223; 1237..1243; 1247..1255; 1270..1277; 1280..1287; 1304..1310; 1314..1324
Beta Strand
32..34; 40..42
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
1..11; Polar residues; 22..31; Basic and acidic residues; 77..86; Polar residues; 87..97; Low complexity; 914..925; Low complexity; 979..989; Basic and acidic residues; 1008..1019; Low complexity
Repeat
1109..1146; ANK 0; degenerate; 1161..1191; ANK 1; 1195..1228; ANK 2; 1233..1262; ANK 3; 1266..1298; ANK 4; 1300..1329; ANK 5
Motif
41..44; Important for binding to TLN1; 43..52; Nuclear export signal 1 (NES 1); 65..68; Nuclear localization signal 1 (NLS 1); 125..134; Nuclear export signal 2 (NES 2); 613..622; Nuclear export signal 3 (NES 3); 979..992; Nuclear localization signal 2 (NLS 2)
Coiled Coil
258..316; 361..395; 446..500
Region
1..31; Disordered; 30..68; KN motif; Interaction with TLN1; 63..103; Disordered; 244..339; Interaction with PPFIBP1; 914..951; Disordered; 979..1026; Disordered; 1073..1352; Interaction with KIF21A; 1331..1352; Disordered