Protein detail

DIP2A

Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1)

Entry name DIP2A	UniProt ID Q14689	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1)

Protein Class (3)

EnzymesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (3)

Enzymes
ENZYME proteins:Ligase
Predicted intracellular proteins

Ensembl

ENSG00000160305

Entrez Gene Symbol

DIP2A

Gene Synonym (3)

C21orf106Dip2KIAA0184

Gene Description

Disco interacting protein 2 homolog A

Chromosome

Position

46458891-46570015

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Single-Nuclei Brain Specificcommitted oligodendrocyte precursorBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway5

Protein Function (3)

Enzymes
ENZYME proteins:Ligase
Predicted intracellular proteins

Cellular Component (5)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence24

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	ICELLNET	No	Yes	No	No	No
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DIP2A	Q14689	SODC	P00441	Yes	Yes	No	SIGNOR	SIGNOR:33781892
DIP2A	Q14689	SRC8	Q14247	Yes	Yes	No	SIGNOR	SIGNOR:31600191
FSTL1	Q12841	DIP2A	Q14689	Yes	Yes	No	ICELLNETSIGNORconnectomeDB2020IntActLit-BM-17	ICELLNET:20054002 IntAct:20860622 connectomeDB2020:20054002 SIGNOR:20054002 Lit-BM-17:20860622
DIP2A	Q14689	SODM	P04179	Yes	Yes	No	SIGNOR	SIGNOR:33781892
DIP2A	Q14689	ABL2	P42684	Yes	Yes	No	SIGNOR	SIGNOR:33622779

Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
DIP2A GTF2A1 GTF2A2 HSPA1L TAF1 TAF11 TAF12 TAF13 TAF2 TAF4 TAF5 TAF6 TAF7 TAF8 TBPL1	O00268 P21675 P34931 P49848 P52655 P52657 P62380 Q14689 Q15542 Q15543 Q15544 Q15545 Q16514 Q6P1X5 Q7Z7C8	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7871
DIP2A NYAP2 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PKN3 PLEKHH3 WDR6	O00329 O00459 P27986 P42336 P42338 Q14689 Q6P5Z2 Q7Z736 Q92569 Q9NNW5 Q9P242	0:0:0:0:0:0:0:0:0:0:0	hu.MAP
ACTL6A DIP2A DMAP1 EPC2 HSPA1L ING3 KAT5 MEAF6 MORF4L1 MORF4L2 MRGBP RUVBL1 TRRAP VPS72 YEATS4	O95619 O96019 P34931 Q14689 Q15014 Q15906 Q52LR7 Q92993 Q9HAF1 Q9NPF5 Q9NV56 Q9NXR8 Q9UBU8 Q9Y265 Q9Y4A5	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8440

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	31	31196968 32284825 33204424 35611462 36797805 32489530 34623918 39766158 30379855 36398564 37786918 38168906 40748658 39940923 37205098 34817906 28986585 27894104 28590090 30646616 30950185 31941606 32295833 33709510 38321535 39558134 39569406 40089067 29148239 30408591 32089743

Sequence, Structure & Domains11

Sequences

Length

1,571

Mass

170,369

Sequence

MADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAKLLARYIPLIQGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQAALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTPLQSHSSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHIDLHSAPPDVTTGLVEHSYFERPQVASVRSVPRGCSGSMLETADGVPVNSRVSSKIQQLLNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPSLLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPLLKPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQQVGFLLGSCGVFLALTTDACQKGLPKAQTGEVAAFKGWPPLSWLVIDGKHLAKPPKDWHPLAQDTGTGTAYIEYKTSKEGSTVGVTVSHASLLAQCRALTQACGYSEAETLTNVLDFKRDAGLWHGVLTSVMNRMHVVSVPYALMKANPLSWIQKVCFYKARAALVKSRDMHWSLLAQRGQRDVSLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRPPDLGGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGANVCVVKLEGTPYLCKTDEVGEICVSSSATGTAYYGLLGITKNVFEAVPVTTGGAPIFDRPFTRTGLLGFIGPDNLVFIVGKLDGLMVTGVRRHNADDVVATALAVEPMKFVYRGRIAVFSVTVLHDDRIVLVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLGGIHISETKQRFLEGTLHPCNVLMCPHTCVTNLPKPRQKQPEVGPASMIVGNLVAGKRIAQASGRELAHLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTATCVQLHKRAERVAAALMEKGRLSVGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVKMIVEVSKSACVLTTQAVTRLLRSKEAAAAVDIRTWPTILDTDDIPKKKIASVFRPPSPDVLAYLDFSVSTTGILAGVKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGAQTGVLRMKGVNLSCVRTCMVVAEERPRIALTQSFSKLFKDLGLPARAVSTTFGCRVNVAICLQGTAGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYYTVYGEEALHADHFSARLSFGDTQTIWARTGYLGFLRRTELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWTNLLVVVVELDGLEQDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMHLRDGFLADQLDPIYVAYNM

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q14689-1; Sequence=Displayed; Name=2; IsoId=Q14689-2; Sequence=VSP_007749; Name=3; IsoId=Q14689-3; Sequence=VSP_007748, VSP_007749; Name=4; IsoId=Q14689-4; Sequence=VSP_007750, VSP_007751; Name=5; IsoId=Q14689-5; Sequence=VSP_045408, VSP_045409, VSP_045410; Name=6; IsoId=Q14689-6; Sequence=VSP_047246

Alternative Sequence

31..94; Missing (in isoform 5); 219..261; Missing (in isoform 3); 302..305; Missing (in isoform 6); 842..1571; Missing (in isoform 2 and isoform 3); 880..889; AIDSIHQVGV -> VGAPARPMVR (in isoform 4); 890..1571; Missing (in isoform 4); 1167..1174; MSHAATSA -> AGRGGSRL (in isoform 5); 1175..1571; Missing (in isoform 5)

Domain & Motif Annotations

Compositional Bias

86..98; Basic and acidic residues; 127..139; Polar residues; 152..162; Polar residues; 174..203; Low complexity

Motif

283..286; PXXP motif; required for interaction with CTTN; 307..310; PXXP motif; required for interaction with CTTN

Domain (FT)

9..127; DMAP1-binding

Region

60..203; Disordered; 302..327; Disordered

Protein Families

DIP2 family

Sequence Similarities

Belongs to the DIP2 family.

Clinical Relevance1

Antibody (2)

HPA044692 HPA052516

Supporting Publications1

PMID	Title	Abstract
38014595	Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia.	No abstract available