Protein detail

PTCA

Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein)

Protein symbol PTCA	UniProt ID Q14761	EVMP score 0.50
Frequency 8	Transmembrane count 1	Protein classification Predicted intracellular proteins

Basic Information

Protein Names

Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Transmembrane

34..54; Helical

Transmembrane Count

Ensembl

ENSG00000213402

Entrez Gene Symbol

PTPRCAP

Gene Synonym

CD45-APLPAP

Gene Description

Protein tyrosine phosphatase receptor type C associated protein

Chromosome

Position

67435510-67437682

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005515 protein binding

Biological Process

Canonical Pathways

M18895 Sa trka receptor
M187 Pid trkr pathway
M153 Pid p75 ntr pathway

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
PTPRCAP	CSNK2A1	P68400	S	153	phosphorylation	PhosphoSite
PTPRCAP	MAPK3	P27361	S	163	phosphorylation	PhosphoSite
PTPRCAP	MAPK1	P28482	S	163	phosphorylation	PhosphoSite

Ligand-Receptor Signaling

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CSK21	P68400	PTCA	Q14761	Yes	Yes	No	SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper	SIGNOR:30482149 PhosphoSite:30482149 PhosphoSite:31661482 PhosphoSite:28827793
MK01	P28482	PTCA	Q14761	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:31537385

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32396726

Sequence, Structure & Domains

Sequences

Length

206

Mass

21,196

Sequence

MALPCTLGLGMLLALPGALGSGGSAEDSVGSSSVTVVLLLLLLLLLATGLALAWRRLSRDSGGYYHPARLGAALWGRTRRLLWASPPGRWLQARAELGSTDNDLERQEDEQDTDYDHVADGGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLVLGSPGPASAGGSAEALLSDLHAFAGSAAWDDSARAAGGQGLHVTAL

3D Structural Models

Domain & Motif Annotations

Compositional Bias

161..173; Low complexity

Region

98..173; Disordered

Clinical Relevance

Antibody

HPA043734