Protein detail

PTCA

Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein)

Entry name PTCA	UniProt ID Q14761	EVMP confidence score 0.50
Supporting publications (n) 8	Transmembrane count 1	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein tyrosine phosphatase receptor type C-associated protein (PTPRC-associated protein) (CD45-associated protein) (CD45-AP) (Lymphocyte phosphatase-associated phosphoprotein)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Transmembrane

34..54; Helical

Transmembrane Count

Ensembl

ENSG00000213402

Entrez Gene Symbol

PTPRCAP

Gene Synonym (2)

CD45-APLPAP

Gene Description

Protein tyrosine phosphatase receptor type C associated protein

Chromosome

Position

67435510-67437682

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificAdrenal cortex cellsSingle-Nuclei Brain SpecificBergmann glia

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005515 protein binding

Biological Process (3)

Canonical Pathways (3)

M18895 Sa trka receptor
M187 Pid trkr pathway
M153 Pid p75 ntr pathway

Mediation Categories

Other mediation

Relations & Evidence21

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
PTPRCAP	CSNK2A1	P68400	S	153	phosphorylation	PhosphoSite
PTPRCAP	MAPK3	P27361	S	163	phosphorylation	PhosphoSite
PTPRCAP	MAPK1	P28482	S	163	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CSK21	P68400	PTCA	Q14761	Yes	Yes	No	SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper	SIGNOR:30482149 PhosphoSite:30482149 PhosphoSite:31661482 PhosphoSite:28827793
MK01	P28482	PTCA	Q14761	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:31537385

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32396726

Sequence, Structure & Domains5

Sequences

Length

206

Mass

21,196

Sequence

MALPCTLGLGMLLALPGALGSGGSAEDSVGSSSVTVVLLLLLLLLLATGLALAWRRLSRDSGGYYHPARLGAALWGRTRRLLWASPPGRWLQARAELGSTDNDLERQEDEQDTDYDHVADGGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLVLGSPGPASAGGSAEALLSDLHAFAGSAAWDDSARAAGGQGLHVTAL

Domain & Motif Annotations

Compositional Bias

161..173; Low complexity

Region

98..173; Disordered

Clinical Relevance1

Antibody

HPA043734

Supporting Publications8

PMID	Title	Abstract
29740045	Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy.	Untargeted proteomics detected markers of exosomes (CD9, CD63, CD81), immune activation (CD14, CRP, HLA-A, HLA-B), oxidative stress (CAT, PRDX1, PRDX2, TXN), and Notch4 in plasma exosomes.
30760538	Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.	No abstract available
31196968	Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
38490958	Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer.	No abstract available
39443544	Profiling of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma in a cross-sectional study.	No abstract available