Protein detail

FXYD3

FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3)

Protein symbol FXYD3	UniProt ID Q14802	EVMP score 0.38
Frequency	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3)

Protein Class

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Transporter channels and pores
Predicted intracellular proteins

Transmembrane

39..59; Helical

Transmembrane Count

Ensembl

ENSG00000089356

Entrez Gene Symbol

FXYD3

Gene Synonym

MAT-8PLML

Gene Description

FXYD domain containing ion transport regulator 3

Chromosome

Position

35115823-35124324

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificConjunctival goblet cells

Function & Pathway

Protein Function

Transporters:Transporter channels and pores
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Canonical Pathways

M99 Pid txa2pathway
M5493 Wnt signaling
M186 Pid pdgfrb pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No

Page 1 of 2Next

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32396726

Sequence, Structure & Domains

Sequences

Length

Mass

9,263

Sequence

MQKVTLGLLVFLAGFPVLDANDLEDKNSPFYYDWHSLQVGGLICAGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=FXYD3-sf; IsoId=Q14802-1; Sequence=Displayed; Name=2; Synonyms=FXYD3-lf; IsoId=Q14802-2; Sequence=VSP_034598; Name=3; IsoId=Q14802-3; Sequence=VSP_045716; Name=4; IsoId=Q14802-4; Sequence=VSP_034598, VSP_047287; Name=5; IsoId=Q14802-5; Sequence=VSP_047286

Alternative Sequence

1; M -> MGRGYSGALQARGGLEEPLERGLRGPSFTQSPLHGAAAAYLSAQRDASLPVPGQRSDM (in isoform 3); 33..87; DWHSLQVGGLICAGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS -> GESPCPLSPPHNPTYCLVPRVPIQGWGLT (in isoform 5); 58; S -> SEWRSSGEQAGRGWGSPPLTTQLSPTG (in isoform 2 and isoform 4); 71..87; Missing (in isoform 4)

3D Structural Models

Domain & Motif Annotations

Region

66..87; Disordered

Protein Families

FXYD family

Sequence Similarities

Belongs to the FXYD family.

Clinical Relevance

Antibody

HPA010856