Protein detail

LASP1

LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)

Protein symbol LASP1	UniProt ID Q14847	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)

Protein Class

Cancer-related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
Cancer-related genes

Ensembl

ENSG00000002834

Entrez Gene Symbol

LASP1

Gene Synonym

Lasp-1MLN50

Gene Description

LIM and SH3 protein 1

Chromosome

Position

38869859-38921770

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificliverBrain Regional Specificchoroid plexusCell SpecificBasal keratinocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

Predicted intracellular proteins
Cancer-related genes

Cellular Component

Molecular Function

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

18 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LASP1	PRKG1	Q13976	S	146	phosphorylation	BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:12432067 KEA:12571245 phosphoELM:12571245 SIGNOR:12571245 ProtMapper:12571245
LASP1	CDK7	P50613	S	146	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEAphosphoELM	phosphoELM:12571245 KEA:12432067 HPRD:18088087 HPRD:20068231 KEA:18088087 KEA:12571245 HPRD:18212344 HPRD:18077418 HPRD:18669648 HPRD:17287340 HPRD:20166139 HPRD:12571245
LASP1	PRKG2	Q13237	S	146	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	phosphoELM:12571245 KEA:12432067 HPRD:18088087 HPRD:20068231 KEA:12571245 HPRD:18212344 HPRD:18077418 HPRD:18669648 HPRD:17287340 HPRD:20166139 SIGNOR:12571245 ProtMapper:12571245 HPRD:12571245
LASP1	PRKG2	Q13237	S	61	phosphorylation	MIMPHPRD_MIMPKEAPhosphoSite_MIMP	KEA:12571245
LASP1	PRKACA	P17612	S	146	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:12432067 ProtMapper:22665060 SIGNOR:22665060 SIGNOR:12432067 SIGNOR:12571245 ProtMapper:12571245
LASP1	PRKACA	P17612	S	99	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:12432067 SIGNOR:12432067
LASP1	ABL1	P00519	Y	171	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:17570479 SIGNOR:15138294 ProtMapper:15465019 ProtMapper:15138294
LASP1	SRC	P12931	Y	171	phosphorylation	Sparser_ProtMapperPhosphoSiteSIGNORProtMapper	SIGNOR:19718473 ProtMapper:25622104
LASP1	PRKCB	P05771	S	146	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:12571245 ProtMapper:12571245
LASP1	PRKAR2B	P31323	S	146	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA	KEA:12432067 HPRD:18088087 HPRD:20068231 KEA:12571245 HPRD:18212344 HPRD:18077418 HPRD:18669648 HPRD:17287340 HPRD:20166139 HPRD:12571245

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Ligand-Receptor Signaling

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
actin_regulation_adhesome	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ABL1	P00519	LASP1	Q14847	Yes	Yes	Yes	WangSparser_ProtMapperphosphoELM_MIMPAdhesomeMIMPPhosphoSite_MIMPHPRD_MIMPPhosphoSite_ProtMapperSIGNORiPTMnetProtMapperKEASIGNOR_ProtMapperREACH_ProtMapperSPIKENetworKIN_KEASPIKE_LC	SPIKE:15138294 Adhesome:15138294 ProtMapper:15465019 SPIKE_LC:20841568 SPIKE:20841568 ProtMapper:32872485 SPIKE_LC:15138294 ProtMapper:15138294 KEA:17570479 SIGNOR:15138294
KAPCA	P17612	LASP1	Q14847	Yes	Yes	Yes	WangphosphoELM_MIMPPhosphoSite_MIMPMIMPAdhesomeHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:25225353 PhosphoSite:22665060 PhosphoSite:12571245 PhosphoSite:26061439 ProtMapper:12432067 ProtMapper:22665060 SIGNOR:22665060 Adhesome:15465019 SIGNOR:12432067 SIGNOR:12571245 ProtMapper:12571245
KGP2	Q13237	LASP1	Q14847	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper	HPRD-phos:18088087 HPRD-phos:18669648 HPRD-phos:12571245 ProtMapper:18077418 HPRD-phos:20068231 ProtMapper:18088087 ProtMapper:18212344 HPRD:12571245 HPRD-phos:18212344 ProtMapper:17287340 phosphoELM:12571245 SIGNOR:12571245 ProtMapper:12571245 HPRD-phos:18077418 KEA:12432067 HPRD-phos:17287340 ProtMapper:20166139 ProtMapper:20068231 KEA:12571245 ProtMapper:18669648 HPRD-phos:20166139
SRC	P12931	LASP1	Q14847	Yes	Yes	No	Sparser_ProtMapperiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:19718473 SIGNOR:19718473 ProtMapper:25622104 ProtMapper:32075106 PhosphoSite:32872485 ProtMapper:32872485 PhosphoSite:24913448 PhosphoSite:32075106 PhosphoSite:15138294
KPCB	P05771	LASP1	Q14847	Yes	No	Yes	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	SIGNOR:12571245 ProtMapper:12571245
KGP1	Q13976	LASP1	Q14847	Yes	No	Yes	BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper	KEA:12432067 KEA:12571245 phosphoELM:12571245 SIGNOR:12571245 ProtMapper:12571245 HPRD:12571245

Protein Complex Composition

10 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CLASP1 KNTC1 UGGT1 ZW10	O43264 P50748 Q7Z460 Q9NYU2	0:0:0:0	Havugimana2012	Havugimana2012:C_360
CLASP1 CLASP2	O75122 Q7Z460	0:0	hu.MAP
ARHGEF38 CLASP1 CLASP2	O75122 Q7Z460 Q9NXL2	0:0:0	hu.MAP2
CLASP1 CLIP1	P30622 Q7Z460	0:0	KEGG-MEDICUS
FHL3 LASP1 PRKAR2B PRKG1 PRKG2	P31323 Q13237 Q13643 Q13976 Q14847	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5518
LASP1 MYLK PRKAR2B PRKG1 PRKG2	P31323 Q13237 Q13976 Q14847 Q15746	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3695
LASP1 MANF PHF3 UACA	P55145 Q14847 Q92576 Q9BZF9	0:0:0:0	hu.MAP
EIF4A1 EIF4E3 EIF4G2 LASP1 THEMIS2	P60842 P78344 Q14847 Q5TEJ8 Q8N5X7	0:0:0:0:0	hu.MAP2
CLASP1	Q7Z460	2	PDB	PDB:6mq7PDB:6mq5PDB:4k92
ARHGEF38 CLASP1	Q7Z460 Q9NXL2	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass Spectrometry	1	38037300

Sequence, Structure & Domains

Sequences

Length

261

Mass

29,717

Sequence

MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14847-1; Sequence=Displayed; Name=2; IsoId=Q14847-2; Sequence=VSP_016554; Name=3; IsoId=Q14847-3; Sequence=VSP_054611

Alternative Sequence

1..83; MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQ -> MLPLRDLQDDTEHEELQGLREEALLQR (in isoform 3); 201..261; GGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI -> ICLQHIPRHRIRPGRDPSILQCLCFLKPATACDSYPSSSFFCQLKPSSATSAGSLLWQASPLIDFLVFSLDGTGMGLSGGGRGPWGRAGMGDLLACGPHLPLCSLPSHPPAQLLTYPHIPGLG (in isoform 2)

3D Structural Models

Turn

245..248

Helix

255..257

Beta Strand

207..211; 228..236; 239..244; 249..254; 258..260

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

121..130; Basic and acidic residues; 167..183; Low complexity

Repeat

61..95; Nebulin 1; 97..131; Nebulin 2

Domain (FT)

5..56; LIM zinc-binding; 202..261; SH3

Region

111..186; Disordered

Clinical Relevance

Disease Involvement

Cancer-related genes

Drug Targets

Literature-reported target

Antibody

HPA012072 CAB022049

Interaction Protein

ENSG00000027869

Interaction Count

Interaction Dataset

intact_biogrid