Protein detail
GPNMB
Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type)
Entry name GPNMB | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information7
Protein Names
Transmembrane glycoprotein NMB (Hematopoietic growth factor inducible neurokinin-1 type)
Protein Function (3)
- Disease related genes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted intracellular proteins
Transmembrane
499..519; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (3)
- Disease related genes
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Predicted intracellular proteins
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
Canonical Pathways (2)
- M15 Pid lysophospholipid pathway
- M186 Pid pdgfrb pathway
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence23
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GPNMB | HIF1A | Q16665 | Y | 525 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:26751287 |
| GPNMB | EGFR | P00533 | Y | 525 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:26751287 |
| GPNMB | PTK6 | Q13882 | Y | 525 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:26751287 |
Ligand-Receptor Signaling (19)
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32396726 |
Sequence, Structure & Domains11
Sequences
Length
572
Mass
63,923
Sequence
MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFVTMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVNHTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLELSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTSTLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14956-1; Sequence=Displayed; Name=2; IsoId=Q14956-2; Sequence=VSP_013001
Alternative Sequence
340..351; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
321..335; Pro residues; 338..351; Polar residues
Motif
64..66; Cell attachment site
Domain (FT)
240..327; PKD
Region
320..362; Disordered
Protein Families
PMEL/NMB family
Sequence Similarities
Belongs to the PMEL/NMB family.