Protein detail
GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)
Protein symbol GAPD1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZP434C212KIAA1521
Gene Description
GTPase activating protein and VPS9 domains 1
Chromosome
9
Position
125261794-125367207
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GAPVD1 | PRKAA1 | Q13131 | S | 902 | phosphorylation | PhosphoSite | |
| GAPVD1 | CDK1 | P06493 | S | 950 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| GAPVD1 | CDK1 | P06493 | S | 977 | phosphorylation | MIMPHPRD_MIMPPhosphoSite_MIMP | |
| GAPVD1 | MAP3K7 | O43318 | T | 1,013 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| GAPVD1 | MAP3K7 | O43318 | S | 1,012 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CSNK1EGAPVD1SNX22SNX24 | P49674Q14C86Q96L94Q9Y343 | 0:0:0:0 | hu.MAP | |||
| GAPVD1HLCSLONRF2SNX22SNX24SPATA46 | P50747Q14C86Q1L5Z9Q5T0L3Q96L94Q9Y343 | 0:0:0:0:0:0 | hu.MAP2 | |||
| GAPVD1HLCSSPATA46 | P50747Q14C86Q5T0L3 | 0:0:0 | hu.MAP | |||
| GAPVD1SNX22SNX24 | Q14C86Q96L94Q9Y343 | 0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32396726 |
Sequence, Structure & Domains
Sequences
Length
1,478
Mass
164,980
Sequence
MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGSDRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNFMKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPIATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSPRLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDGESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q14C86-1; Sequence=Displayed; Name=2; IsoId=Q14C86-2; Sequence=VSP_032362; Name=3; IsoId=Q14C86-3; Sequence=VSP_032361, VSP_032362; Name=4; IsoId=Q14C86-4; Sequence=VSP_032358, VSP_032362; Name=5; IsoId=Q14C86-5; Sequence=VSP_032359; Name=6; IsoId=Q14C86-6; Sequence=VSP_032360, VSP_032362
Alternative Sequence
557..577; Missing (in isoform 4); 810..835; Missing (in isoform 5); 810; G -> DFLYILQPKQHFQHIEAEADMRIQLSSS (in isoform 6); 989..1015; Missing (in isoform 3); 1057..1074; Missing (in isoform 2, isoform 3, isoform 4 and isoform 6)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
578..588; Polar residues; 758..777; Polar residues; 778..789; Basic and acidic residues; 889..902; Basic and acidic residues; 954..975; Basic and acidic residues; 997..1008; Basic and acidic residues; 1012..1023; Polar residues
Domain (FT)
147..385; Ras-GAP; 1338..1478; VPS9
Region
574..608; Disordered; 739..820; Disordered; 846..874; Disordered; 889..1023; Disordered; 1043..1064; Disordered
Protein Families
GAPVD1 family
Sequence Similarities
Belongs to the GAPVD1 family.
Clinical Relevance
Interaction Protein
ENSG00000108953ENSG00000113712ENSG00000141551ENSG00000166913ENSG00000170027ENSG00000213923
Interaction Count
6
Interaction Dataset
biogrid_opencellintact_biogrid_opencell