Protein detail

GAPD1

GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)

Entry name GAPD1	UniProt ID Q14C86	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000165219

Entrez Gene Symbol

GAPVD1

Gene Synonym (2)

DKFZP434C212KIAA1521

Gene Description

GTPase activating protein and VPS9 domains 1

Chromosome

Position

125261794-125367207

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (6)

Biological Process (3)

Reactome (5)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence14

Enzyme-Mediated Modification (5)

5 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
GAPVD1	PRKAA1	Q13131	S	902	phosphorylation	PhosphoSite
GAPVD1	CDK1	P06493	S	950	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
GAPVD1	CDK1	P06493	S	977	phosphorylation	MIMPHPRD_MIMPPhosphoSite_MIMP
GAPVD1	MAP3K7	O43318	T	1,013	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
GAPVD1	MAP3K7	O43318	S	1,012	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
CSNK1E GAPVD1 SNX22 SNX24	P49674 Q14C86 Q96L94 Q9Y343	0:0:0:0	hu.MAP
GAPVD1 HLCS LONRF2 SNX22 SNX24 SPATA46	P50747 Q14C86 Q1L5Z9 Q5T0L3 Q96L94 Q9Y343	0:0:0:0:0:0	hu.MAP2
GAPVD1 HLCS SPATA46	P50747 Q14C86 Q5T0L3	0:0:0	hu.MAP
GAPVD1 SNX22 SNX24	Q14C86 Q96L94 Q9Y343	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32396726

Sequence, Structure & Domains10

Sequences

Length

1,478

Mass

164,980

Sequence

MVKLDIHTLAHHLKQERLYVNSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPSQQEKLFGEKGSDRFRQKVQEMVESNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGSEEGDPRTKSSLGKFDKSCVAAFLDVVIGGRAVETPPLSSVNLLEGLSRTVVYITYSQLITLVNFMKSVMSGDQLREDRMALDNLLANLPPAKPGKSSSLEMTPYNTPQLSPATTPANKKNRLPIATRSRSRTNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNIDEDRLQEIAGAAAENMLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDEITHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTPAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEERELPPAAAIGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDEKSDRNRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDDPSPRLSAQAQVAEDILDKYRNAIKRTSPSDGAMANYESTGDNHDRDLSSKLLYHSDKEVMGDGESAHDSPRDEALQNISADDLPDSASQAAHPQDSAFSYRDAKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKNLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK

Alternative Products

Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q14C86-1; Sequence=Displayed; Name=2; IsoId=Q14C86-2; Sequence=VSP_032362; Name=3; IsoId=Q14C86-3; Sequence=VSP_032361, VSP_032362; Name=4; IsoId=Q14C86-4; Sequence=VSP_032358, VSP_032362; Name=5; IsoId=Q14C86-5; Sequence=VSP_032359; Name=6; IsoId=Q14C86-6; Sequence=VSP_032360, VSP_032362

Alternative Sequence

557..577; Missing (in isoform 4); 810..835; Missing (in isoform 5); 810; G -> DFLYILQPKQHFQHIEAEADMRIQLSSS (in isoform 6); 989..1015; Missing (in isoform 3); 1057..1074; Missing (in isoform 2, isoform 3, isoform 4 and isoform 6)

Domain & Motif Annotations

Compositional Bias

578..588; Polar residues; 758..777; Polar residues; 778..789; Basic and acidic residues; 889..902; Basic and acidic residues; 954..975; Basic and acidic residues; 997..1008; Basic and acidic residues; 1012..1023; Polar residues

Domain (FT)

147..385; Ras-GAP; 1338..1478; VPS9

Region

574..608; Disordered; 739..820; Disordered; 846..874; Disordered; 889..1023; Disordered; 1043..1064; Disordered

Protein Families

GAPVD1 family

Sequence Similarities

Belongs to the GAPVD1 family.

Clinical Relevance5

Drugs (2)

INTERFERON BETA-1A INTERFERON BETA-1B

Antibody (3)

HPA029386 HPA029387 HPA074882

Interaction Protein (6)

ENSG00000108953ENSG00000113712ENSG00000141551ENSG00000166913ENSG00000170027ENSG00000213923

Interaction Count

Interaction Dataset (2)

biogrid_opencellintact_biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
36394150	A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer.	No abstract available