Protein detail
RHG19
Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19)
Protein symbol RHG19 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ00194MGC14258
Gene Description
Rho GTPase activating protein 19
Chromosome
10
Position
97222173-97292673
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBergmann gliaSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ARHGAP19 | CDK1 | P06493 | T | 404 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARHGAP19 | CDK1 | P06493 | T | 476 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARHGAP19 | ROCK1 | Q13464 | S | 422 | phosphorylation | Sparser_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:29420299 |
| ARHGAP19 | AKT1 | P31749 | S | 422 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARHGAP19 | CDK2 | P24941 | T | 476 | phosphorylation | MIMPPhosphoSite_MIMP | |
| ARHGAP19 | CDK2 | P24941 | T | 478 | phosphorylation | MIMPPhosphoSite_MIMP | |
| ARHGAP19 | ROCK2 | O75116 | S | 422 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:29420299 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RHG19 | Q14CB8 | RHOA | P61586 | Yes | No | Yes | SIGNOR | SIGNOR:32203420 |
| AKT1 | P31749 | RHG19 | Q14CB8 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:29420299 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
494
Mass
55,756
Sequence
MATEAQSEGEVPARESGRSDAICSFVICNDSSLRGQPIIFNPDFFVEKLRHEKPEIFTELVVSNITRLIDLPGTELAQLMGEVDLKLPGGAGPASGFFRSLMSLKRKEKGVIFGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKIADLMQFDDKGNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTANDLQENITKLNSGMAFMIKHSQKLFKAPAYIRECARLHYLGSRTQASKDDLDLIASCHTKSFQLAKSQKRNRVDSCPHQEETQHHTEEALRELFQHVHDMPESAKKKQLIRQFNKQSLTQTPGREPSTSQVQKRARSRSFSGLIKRKVLGNQMMSEKKKKNPTPESVAIGELKGTSKENRNLLFSGSPAVTMTPTRLKWSEGKKEGKKGFL
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q14CB8-1; Sequence=Displayed; Name=2; IsoId=Q14CB8-2; Sequence=VSP_023701; Name=3; IsoId=Q14CB8-3; Sequence=VSP_023696; Name=4; IsoId=Q14CB8-4; Sequence=VSP_023695; Name=5; IsoId=Q14CB8-5; Sequence=VSP_023698, VSP_023699; Name=6; IsoId=Q14CB8-6; Sequence=VSP_023697; Name=7; IsoId=Q14CB8-7; Sequence=VSP_023700
Alternative Sequence
1..382; Missing (in isoform 4); 1..19; MATEAQSEGEVPARESGRS -> MPHQKLSALI (in isoform 3); 281..309; Missing (in isoform 6); 281..301; VTANDLQENITKLNSGMAFMI -> GLVLLPTLEESNTITTHCSLI (in isoform 5); 302..494; Missing (in isoform 5); 332..346; Missing (in isoform 7); 493..494; FL -> NSMATTSLGSIRMTLRGSSSCGCCS (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
354..368; Basic and acidic residues; 399..415; Polar residues
Domain (FT)
102..308; Rho-GAP
Region
349..368; Disordered; 399..421; Disordered