Protein detail

RHG19

Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19)

Entry name RHG19	UniProt ID Q14CB8	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000213390

Entrez Gene Symbol

ARHGAP19

Gene Synonym (2)

FLJ00194MGC14258

Gene Description

Rho GTPase activating protein 19

Chromosome

Position

97222173-97292673

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificBergmann gliaSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (5)

Molecular Function (2)

Biological Process (3)

Reactome (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence16

Enzyme-Mediated Modification (7)

7 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ARHGAP19	CDK1	P06493	T	404	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
ARHGAP19	CDK1	P06493	T	476	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
ARHGAP19	ROCK1	Q13464	S	422	phosphorylation	Sparser_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:29420299
ARHGAP19	AKT1	P31749	S	422	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
ARHGAP19	CDK2	P24941	T	476	phosphorylation	MIMPPhosphoSite_MIMP
ARHGAP19	CDK2	P24941	T	478	phosphorylation	MIMPPhosphoSite_MIMP
ARHGAP19	ROCK2	O75116	S	422	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:29420299

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
RHG19	Q14CB8	RHOA	P61586	Yes	No	Yes	SIGNOR	SIGNOR:32203420
AKT1	P31749	RHG19	Q14CB8	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:29420299

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARHGAP19 CILP2 CLSTN1 DEFA5 GLCE	O94923 O94985 Q01523 Q14CB8 Q8IUL8	0:0:0:0:0	hu.MAP2
	ARHGAP19 DEFA5	Q01523 Q14CB8	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains8

Sequences

Length

494

Mass

55,756

Sequence

MATEAQSEGEVPARESGRSDAICSFVICNDSSLRGQPIIFNPDFFVEKLRHEKPEIFTELVVSNITRLIDLPGTELAQLMGEVDLKLPGGAGPASGFFRSLMSLKRKEKGVIFGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQILRDALNNGTDIDLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKIADLMQFDDKGNKTNIPDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVLWPKNVTANDLQENITKLNSGMAFMIKHSQKLFKAPAYIRECARLHYLGSRTQASKDDLDLIASCHTKSFQLAKSQKRNRVDSCPHQEETQHHTEEALRELFQHVHDMPESAKKKQLIRQFNKQSLTQTPGREPSTSQVQKRARSRSFSGLIKRKVLGNQMMSEKKKKNPTPESVAIGELKGTSKENRNLLFSGSPAVTMTPTRLKWSEGKKEGKKGFL

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q14CB8-1; Sequence=Displayed; Name=2; IsoId=Q14CB8-2; Sequence=VSP_023701; Name=3; IsoId=Q14CB8-3; Sequence=VSP_023696; Name=4; IsoId=Q14CB8-4; Sequence=VSP_023695; Name=5; IsoId=Q14CB8-5; Sequence=VSP_023698, VSP_023699; Name=6; IsoId=Q14CB8-6; Sequence=VSP_023697; Name=7; IsoId=Q14CB8-7; Sequence=VSP_023700

Alternative Sequence

1..382; Missing (in isoform 4); 1..19; MATEAQSEGEVPARESGRS -> MPHQKLSALI (in isoform 3); 281..309; Missing (in isoform 6); 281..301; VTANDLQENITKLNSGMAFMI -> GLVLLPTLEESNTITTHCSLI (in isoform 5); 302..494; Missing (in isoform 5); 332..346; Missing (in isoform 7); 493..494; FL -> NSMATTSLGSIRMTLRGSSSCGCCS (in isoform 2)

Domain & Motif Annotations

Compositional Bias

354..368; Basic and acidic residues; 399..415; Polar residues

Domain (FT)

102..308; Rho-GAP

Region

349..368; Disordered; 399..421; Disordered

Clinical Relevance4

Antibody (2)

HPA035777 HPA043231

Interaction Protein

ENSG00000170027

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
38250192	Bone-Targeting Peptide and RNF146 Modified Apoptotic Extracellular Vesicles Alleviate Osteoporosis.	No abstract available