Protein detail
HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1)
Entry name HERP1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 2 | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1)
Protein Class (4)
Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- Predicted intracellular proteins
- Cancer-related genes
Transmembrane
264..284; Helical; 290..310; Helical
Transmembrane Count
2
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
HERPKIAA0025Mif1SUP
Gene Description
Homocysteine inducible ER protein with ubiquitin like domain 1
Chromosome
16
Position
56932142-56944864
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue Specificskeletal muscleCell SpecificDistal convoluted tubule cellsBlood Cell Specificneutrophil
Function & Pathway8
Protein Function (2)
- Predicted intracellular proteins
- Cancer-related genes
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
Reactome (4)
Canonical Pathways (3)
- M5887 Naba basement membranes
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence21
Ligand-Receptor Signaling (14)
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
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Regulatory Interaction Network (3)
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SH3R1 | Q7Z6J0 | HERP1 | Q15011 | Yes | Yes | No | Lit-BM-17SIGNOR | Lit-BM-17:17420289SIGNOR:20976103 |
| HERP1 | Q15011 | BIP | P11021 | Yes | Yes | No | SIGNOR | SIGNOR:29295953 |
| SYVN1 | Q86TM6 | HERP1 | Q15011 | Yes | Yes | No | HINTSIGNOR | SIGNOR:28827405HINT:28827405HINT:16289116 |
Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 32560723 |
Sequence, Structure & Domains12
Sequences
Length
391
Mass
43,720
Sequence
MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN
Alternative Products
Event=Alternative splicing; Named isoforms=4; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q15011-1; Sequence=Displayed; Name=2; IsoId=Q15011-2; Sequence=VSP_006708; Name=3; IsoId=Q15011-3; Sequence=VSP_006708, VSP_006709; Name=4; IsoId=Q15011-4; Sequence=VSP_047333
Alternative Sequence
75..99; Missing (in isoform 4); 76; Missing (in isoform 2 and isoform 3); 145..302; Missing (in isoform 3)
3D Structural Models
Turn
51..53
Helix
34..44; 69..72
Beta Strand
11..15; 17..20; 24..27; 55..58; 65..67; 75..77; 79..85
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
112..124; Polar residues; 346..357; Basic and acidic residues
Domain (FT)
10..72; Ubiquitin-like
Region
100..126; Disordered; 115..200; Interaction with UBQLN1; 170..190; Interaction with SYVN1; 318..359; Disordered
Clinical Relevance2
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 33580572 | Human myeloma cell- and plasma-derived extracellular vesicles contribute to functional regulation of stromal cells. | No abstract available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 38490958 | Proteomic analysis of ascitic extracellular vesicles describes tumour microenvironment and predicts patient survival in ovarian cancer. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |