Protein detail
ARHG6
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Entry name ARHG6 | UniProt ID | EVMP score 0.38 |
Frequency 5 | Transmembrane count | Protein classification Cancer-related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Protein Class
Cancer-related genesPredicted intracellular proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
alpha-PIXalphaPIXCool-2Cool2KIAA0006MRX46
Gene Description
Rac/Cdc42 guanine nucleotide exchange factor 6
Chromosome
X
Position
136665547-136780932
Frequency
5
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-1500931 cell cell communication
- R-hsa-204998 cell death signalling via nrage nrif and nade
- R-hsa-446353 cell extracellular matrix interactions
- R-hsa-446728 cell junction organization
- R-hsa-73887 death receptor signaling
- R-hsa-416482 g alpha 12 13 signalling events
- R-hsa-8964616 g beta gamma signalling through cdc42
- R-hsa-397795 g protein beta gamma signalling
- R-hsa-193648 nrage signals death through jnk
- R-hsa-193704 p75 ntr receptor mediated signalling
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-446388 regulation of cytoskeletal remodeling and cell spreading by ipp complex components
- R-hsa-9013420 rhou gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-372790 signaling by gpcr
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ARHGEF6 | PRKCQ | Q04759 | S | 225 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARHGEF6 | PRKCQ | Q04759 | S | 488 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARHGEF6 | PRKACA | P17612 | S | 684 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARHGEF6 | PRKG1 | Q13976 | S | 684 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| ARHGEF6 | GSK3B | P49841 | S | 225 | phosphorylation | KEA | KEA:17570479 |
| ARHGEF6 | MAPK9 | P45984 | S | 225 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | ARHG6 | Q15052 | Yes | No | Yes | iPTMnetPhosphoSite_norefSIGNORProtMapperPhosphoSite_ProtMapper | SIGNOR:26507661 |
| ASAP3 | Q8TDY4 | ARHG6 | Q15052 | Yes | Yes | No | SIGNOR | SIGNOR:23776207 |
| KPCT | Q04759 | ARHG6 | Q15052 | Yes | Yes | No | PhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:25694429SIGNOR:25694429 |
| GIT1 | Q9Y2X7 | ARHG6 | Q15052 | Yes | Yes | No | AdhesomeSIGNORHPRDHINTWangLit-BM-17 | Adhesome:10428811Adhesome:21900206Lit-BM-17:21900206Adhesome:10592173HPRD:10896954HINT:10896954Adhesome:16373173SIGNOR:26507661Adhesome:10896954Lit-BM-17:10428811HINT:33961781 |
| ARHG6 | Q15052 | RAC1 | P63000 | Yes | Yes | No | WangSIGNORAdhesome | Adhesome:16492808SIGNOR:26507661Adhesome:10592173 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyPolymer PrecipitationImmunoaffinity Capture | Mass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF]Small R sequencing (Illumi HiSeq 2000 (Solexa) | 52 | 31196968322848253234135733204424356114623679780532489530327598203294419334623918366121723976615839940641294367803037985536398564377869183816890636217952407486583994092339505756394090153720509834817906331694212723450528986585405634752163046222740476278941042859009029045505296876282974004530646616309501853108114931941606322958333457182838321535395581343956940634445582200316102914823930408591320897432914823939569406 |
Sequence, Structure & Domains
Sequences
Length
776
Mass
87,499
Sequence
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15052-1; Sequence=Displayed; Name=2; IsoId=Q15052-2; Sequence=VSP_015782
Alternative Sequence
1..154; Missing (in isoform 2)
3D Structural Models
Turn
211..213
Helix
4..14; 27..37; 39..48; 63..80; 87..91; 96..110; 219..222
Beta Strand
163..166; 187..191; 194..196; 198..202; 205..209; 214..216
3D Structure
NMR spectroscopy (2)
Domain & Motif Annotations
Compositional Bias
121..151; Polar residues; 561..572; Low complexity
Domain (FT)
1..111; Calponin-homology (CH); 160..219; SH3; 241..421; DH; 443..548; PH
Region
115..151; Disordered; 561..581; Disordered