Protein detail
RAGE
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Entry name RAGE | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Protein Class
Cancer-related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Transmembrane
343..363; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
RAGESCARJ1sRAGE
Gene Description
Advanced glycosylation end-product specific receptor
Chromosome
6
Position
32180968-32184322
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificFoveolar cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0004888 transmembrane signaling receptor activity
- GO:0005044 scavenger receptor activity
- GO:0005055 laminin receptor activity
- GO:0005515 protein binding
- GO:0038023 signaling receptor activity
- GO:0042802 identical protein binding
- GO:0044548 S100 protein binding
- GO:0044877 protein-containing complex binding
- GO:0050785 advanced glycation end-product receptor activity
- GO:0060090 molecular adaptor activity
Biological Process
KEGG
- hsa04148 Efferocytosis
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04933 AGE-RAGE signaling pathway in diabetic complications
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05415 Diabetic cardiomyopathy
- KEGG:hsa05417 Lipid and atherosclerosis
Reactome
- R-hsa-879415 advanced glycosylation endproduct receptor signaling
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-168928 ddx58 ifih1 mediated induction of interferon alpha beta
- R-hsa-168249 innate immune system
- R-hsa-446652 interleukin 1 family signaling
- R-hsa-9020702 interleukin 1 signaling
- R-hsa-166166 myd88 independent tlr4 cascade
- R-hsa-449147 signaling by interleukins
- R-hsa-445989 tak1 dependent ikk and nf kappa b activation
- R-hsa-168138 toll like receptor 9 tlr9 cascade
- R-hsa-168898 toll like receptor cascades
- R-hsa-168179 toll like receptor tlr1 tlr2 cascade
- R-hsa-933542 traf6 mediated nf kb activation
Canonical Pathways
M90 Pid wnt canonical pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AGER | ATM | Q13315 | S | 391 | phosphorylation | Sparser_ProtMapperProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:28977635 |
| AGER | PRKCZ | Q05513 | S | 391 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| ig | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | No |
| extracellular | extracellular | LOCATE | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | LOCATE | No | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
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Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| S10A8 | P05109 | RAGE | Q15109 | Yes | Yes | No | CellinkerCellTalkDBSIGNOR | Cellinker:28504650CellTalkDB:28504650SIGNOR:28137827 |
| ATM | Q13315 | RAGE | Q15109 | Yes | Yes | No | Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | ProtMapper:28977635SIGNOR:28977635 |
| HMGB1 | P09429 | RAGE | Q15109 | Yes | Yes | No | CellTalkDBSparser_ProtMapperSIGNORProtMapperHPRDHINTInnateDBCellinkerWang | HPRD:9812979Cellinker:20192808HINT:24474694InnateDB:19727205SIGNOR:25014009CellTalkDB:32296583 |
| COMPLEX:P05109_P06702 | RAGE | Q15109 | Yes | Yes | No | SIGNOR | SIGNOR:28137827 | |
| S10A9 | P06702 | RAGE | Q15109 | Yes | Yes | No | InnateDBCellinkerCellTalkDBSIGNOR | Cellinker:28504650InnateDB:23667563CellTalkDB:28504650SIGNOR:28137827 |
| KPCZ | Q05513 | RAGE | Q15109 | Yes | No | No | ProtMapperIntActInnateDBPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:25002577IntAct:21829704PhosphoSite:21829704InnateDB:21829704 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AGERS100B | P04271Q15109 | 4:1 | PDB | PDB:4xynPDB:5d7f | ||
| AGERHMGB1 | P09429Q15109 | 1:1 | PDB | PDB:8i9m | ||
| AGERS100P | P25815Q15109 | 2:2 | PDB | PDB:2mjw | ||
| AGER | Q15109 | 2 | PDB | PDB:6xq8PDB:6xq1PDB:7lmwPDB:4ofvPDB:6xq3PDB:6xq5PDB:6xq7PDB:4oi7PDB:4lp5PDB:4lp4PDB:6xq9PDB:7lmlPDB:4of5PDB:6xq6PDB:4oi8 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 32560723 |
Sequence, Structure & Domains
Sequences
Length
404
Mass
42,803
Sequence
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
Alternative Products
Event=Alternative splicing; Named isoforms=10; Name=1; IsoId=Q15109-1; Sequence=Displayed; Name=2; Synonyms=RAGESEC; IsoId=Q15109-2; Sequence=VSP_002551, VSP_002552; Name=3; IsoId=Q15109-3; Sequence=VSP_042011; Name=4; IsoId=Q15109-4; Sequence=VSP_043528, VSP_042011; Name=5; Synonyms=del exon3-7; IsoId=Q15109-5; Sequence=VSP_047884, VSP_047885; Name=6; IsoId=Q15109-6; Sequence=VSP_043528; Name=7; Synonyms=del exon3; IsoId=Q15109-7; Sequence=VSP_002551; Name=8; IsoId=Q15109-8; Sequence=VSP_047886, VSP_047888; Name=9; Synonyms=del exon8-9; IsoId=Q15109-9; Sequence=VSP_047887, VSP_047889; Name=10; Synonyms=delta-ICD, variant 20; IsoId=Q15109-10; Sequence=VSP_055321
Alternative Sequence
54..67; Missing (in isoform 2 and isoform 7); 113..121; YRVRVYQIP -> WWWSQKVEQ (in isoform 5); 122..404; Missing (in isoform 5); 140; K -> KVVEESRRSRKRPCEQE (in isoform 4 and isoform 6); 275..404; GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP -> VSDLERGAGRTRRGGANCRLCGRIRAGNSSPGPGDPGRPGDSRPAHWGHLVAKAATPRRGEEGPRKPGGRGGACRTESVGGT (in isoform 2); 275..325; GVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGE -> NQARRGQLQVRGLIKSGKQKIAPNTCDWGDGQQERNGRPQKTRRKRRSVQN (in isoform 8); 276..355; VPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAA -> LRTREPTAVWPPIPATGPRKAVLSASASSNQARRGQLQVRGLIKSGKQKIAPNTCDWGDGQQERNGRPQKTRRKRRSVQN (in isoform 9); 326..404; Missing (in isoform 8); 332..404; SVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP -> EGFDKVREAEDSPQHM (in isoform 3 and isoform 4); 356..404; Missing (in isoform 9); 374..404; KAPENQEEEEERAELNQSEEPEAGESSTGGP -> PQKTRRKRRSVQN (in isoform 10)
3D Structural Models
Turn
80..82; 104..106; 166..169; 181..183; 367..369
Helix
71..74; 91..93; 293..295
Beta Strand
24..29; 34..36; 43..46; 48..55; 58..60; 62..64; 76..78; 84..88; 95..102; 108..119; 125..128; 131..133; 139..151; 154..159; 162..164; 171..179; 186..194; 206..211; 213..216; 228..230; 237..244; 247..249; 251..253; 255..260; 262..264; 268..273; 284..288; 297..305; 308..312; 316..320; 322..324; 364..366; 371..373
3D Structure
Electron microscopy (1); NMR spectroscopy (10); X-ray crystallography (21)
Domain & Motif Annotations
Compositional Bias
378..396; Acidic residues
Domain (FT)
23..116; Ig-like V-type; 124..221; Ig-like C2-type 1; 227..317; Ig-like C2-type 2
Region
367..404; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 3; Phase 2/3
Drug Targets
Clinical trial target
Drugs