Protein detail

KPCD1

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Protein symbol KPCD1	UniProt ID Q15139	EVMP score 0.72
Frequency 16	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Basic Information

Protein Names

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Protein Class

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Ensembl

ENSG00000184304

Entrez Gene Symbol

PRKD1

Gene Synonym

PKC-muPKCMPKDPRKCM

Gene Description

Protein kinase D1

Chromosome

Position

29576479-30191898

Frequency

EVMP Score

0.72

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

68 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PRKD1	PRKCA	P17252	S	742	phosphorylation	BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 ProtMapper:15212693 KEA:11948398 KEA:15383279 phosphoELM:15383279 SIGNOR:10197446 KEA:11741879 phosphoELM:11948398 KEA:17570479 ProtMapper:10197446
PRKD1	PRKCA	P17252	S	738	phosphorylation	BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 ProtMapper:15212693 KEA:11948398 KEA:15383279 phosphoELM:15383279 SIGNOR:10197446 KEA:11741879 phosphoELM:11948398 KEA:17570479 ProtMapper:10197446
PRKD1	PRKCA	P17252	S	412	phosphorylation	PhosphoSite
PRKD1	PRKCA	P17252	S	205	phosphorylation	PhosphoNetworks
PRKD1	PRKCA	P17252	S	420	phosphorylation	PhosphoNetworks
PRKD1	PRKCA	P17252	S	249	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:10867018
PRKD1	PRKCH	P24723	S	742	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 phosphoELM:15024053 KEA:11948398 KEA:15383279 SIGNOR:10197446 KEA:11741879 ProtMapper:10197446
PRKD1	PRKCH	P24723	S	738	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 phosphoELM:11741879 phosphoELM:15024053 KEA:11948398 KEA:15383279 SIGNOR:10197446 HPRD:10867018 KEA:11741879 ProtMapper:10197446 HPRD:11741879
PRKD1	PRKCH	P24723	S	549	phosphorylation	PhosphoNetworks
PRKD1	PRKCD	Q05655	S	742	phosphorylation	BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 SIGNOR:15024053 ProtMapper:15024053 ProtMapper:15212693 phosphoELM:15024053 KEA:11948398 KEA:15383279 KEA:11741879

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Ligand-Receptor Signaling

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

59 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCD1	Q15139	HSPB1	P04792	Yes	Yes	No	SPIKESparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetphosphoELMProtMapperRLIMS-P_ProtMapperHINTInnateDBSPIKE_LCREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:34498800 ProtMapper:28361035 PhosphoSite:18510930 PhosphoSite:12740362 PhosphoSite:25189701 ProtMapper:18440775 ProtMapper:22357851 ProtMapper:24323422 SPIKE:19767773 ProtMapper:19767773 HINT:15728188 PhosphoSite:15249501 ProtMapper:25747583 PhosphoSite:33477989 ProtMapper:20621068 PhosphoSite:11912188 HINT:18440775 phosphoELM:15728188 PhosphoSite:1730670 PhosphoSite:24816797 ProtMapper:18720982 InnateDB:18440775 ProtMapper:33557752 PhosphoSite:14749215 SPIKE_LC:19767773 PhosphoSite:25525152
KPCD1	Q15139	HDAC7	Q8WUI4	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAHPRDWangPhosphoSite_ProtMapperHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperSPIKE_LCSPIKE	HPRD:15738054 PhosphoSite:15623513 ProtMapper:15623513 PhosphoSite:20166139 HPRD:15623513 dbPTM:17962809 HPRD-phos:18669648 ProtMapper:18617643 HPRD-phos:18767875 ProtMapper:18509061 HPRD-phos:15623513 KEA:16956611 ProtMapper:21680539 ProtMapper:15738054 ProtMapper:28174229 SIGNOR:15623513 HPRD-phos:20068231 PhosphoSite:18617643 ProtMapper:28577984 PhosphoSite:22251793 KEA:15738054 SIGNOR:15738054 ProtMapper:18767875 PhosphoSite:18509061 phosphoELM:15623513 dbPTM:16980613 phosphoELM:18509061 ProtMapper:16956611 SIGNOR:18617643 phosphoELM:18617643 HPRD-phos:16956611 SPIKE:15623513 KEA:15623513 HPRD-phos:15738054 ProtMapper:20068231 SPIKE_LC:15623513 PhosphoSite:16980613 SIGNOR:18509061
KPCD1	Q15139	PLCG1	P19174	Yes	Yes	Yes	SPIKEWangphosphoELM_MIMPPhosphoSite_MIMPMIMPNetPathHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosSPIKE_LC	HPRD-phos:8885868 KEA:1370476 SPIKE_LC:8885868 SPIKE:8885868 ProtMapper:19651622 ProtMapper:20068231 HPRD-phos:20068231 ProtMapper:1370476 NetPath:8885868 HPRD:8885868 SIGNOR:1370476 KEA:8885868 HPRD-phos:19651622 ProtMapper:8885868
ABL1	P00519	KPCD1	Q15139	Yes	Yes	No	KEGG-MEDICUSHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEALi2012HPRDKinexus_KEAPhosphoSite_ProtMapperBEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperSPIKE_LCSPIKE	PhosphoSite:12505989 HPRD:12637538 ProtMapper:15024053 ProtMapper:15212693 KEA:12637538 ProtMapper:23329794 SPIKE_LC:20841568 PhosphoSite:12637538 ProtMapper:23717204 ProtMapper:12505989 ProtMapper:28174535 ProtMapper:12637538 SIGNOR:12637538 phosphoELM:12637538 KEA:12505989 SPIKE:12637538 PhosphoSite:16891660 phosphoELM:12505989 SPIKE_LC:12637538 ProtMapper:29933512 SPIKE:20841568
1433T	P27348	KPCD1	Q15139	Yes	Yes	No	HPRDHINTSignaLink3SPIKE_LC	HPRD:10092600 HINT:10831594 SPIKE_LC:16713569 SignaLink3:23331499 HINT:10092600 SignaLink3:10092600
KPCD1	Q15139	PP14A	Q96A00	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperphosphoELMHPRDPhosphoSite_KEAKEAHPRD_KEAInnateDBSIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper	PhosphoSite:15184667 PhosphoSite:16472257 SIGNOR:32471307 KEA:15665049 KEA:11287002 phosphoELM:15003508 HPRD-phos:15003508 ProtMapper:32471307 ProtMapper:15003508 PhosphoSite:12495628 KEA:15184667 PhosphoSite:15003508 PhosphoSite:11287002 HPRD:15003508 InnateDB:15003508 KEA:12604330 KEA:12030846 KEA:15003508
KPCD1	Q15139	SSH1	Q8WYL5	Yes	Yes	Yes	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:19329994 SIGNOR:19567672 SIGNOR:21525957 ProtMapper:26873625 PhosphoSite:15159416 PhosphoSite:21525957 PhosphoSite:19567672 SIGNOR:21832093 ProtMapper:19329994 PhosphoSite:23737525 ProtMapper:33324642 ProtMapper:23688773 SIGNOR:23841590 PhosphoSite:24962708 PhosphoSite:24840177 ProtMapper:21525957 ProtMapper:25266776 ProtMapper:23153585 ProtMapper:19567672
KPCD1	Q15139	MFF	Q9GZY8	Yes	Yes	No	PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:34010649 PhosphoSite:34010649
KPCD1	Q15139	RIN1	Q13671	Yes	No	Yes	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperdbPTMphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:21357900 SIGNOR:21209314 ProtMapper:12829240 ProtMapper:11784866 PhosphoSite:11784866 SIGNOR:11784866 ProtMapper:21209314 phosphoELM:11784866 dbPTM:11784866 dbPTM:18669648
KPCL	P24723	KPCD1	Q15139	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDKinexus_KEAPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos	KEA:15024053 HPRD-phos:10867018 KEA:10867018 ProtMapper:10867018 phosphoELM:11741879 phosphoELM:15024053 KEA:11948398 KEA:15383279 SIGNOR:10197446 HPRD:10867018 HPRD-phos:11741879 KEA:11741879 ProtMapper:11741879 ProtMapper:10197446 HPRD:11741879

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Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	32560723

Sequence, Structure & Domains

Sequences

Length

912

Mass

101,704

Sequence

MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL

3D Structural Models

Domain & Motif Annotations

Zinc Finger

146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2

Domain (FT)

422..541; PH; 583..839; Protein kinase

Region

377..402; Disordered

Protein Families

Protein kinase superfamily
CAMK Ser/Thr protein kinase family
PKD subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.

Clinical Relevance

Disease Involvement

Disease variantEctodermal dysplasia

Related Diseases

Solid tumour/cancer Urinary system disease

Biomarker

Investigative

Drugs

UCN-01 GSK-690693 SOTRASTAURIN ARGIPRESSIN BRYOSTATIN MIDOSTAURIN RESVERATROL BRYOSTATIN 1 CEP-2563 QUERCETIN

Antibody

CAB018367 HPA029834

Interaction Protein

ENSG00000065054ENSG00000108561ENSG00000125148

Interaction Count

Interaction Dataset

intact_biogrid