Protein detail

KPCD1

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Entry name KPCD1	UniProt ID Q15139	EVMP confidence score 0.72
Supporting publications (n) 16	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Ensembl

ENSG00000184304

Entrez Gene Symbol

PRKD1

Gene Synonym (4)

PKC-muPKCMPKDPRKCM

Gene Description

Protein kinase D1

Chromosome

Position

29576479-30191898

Supporting publications (n)

EVMP confidence score

0.72

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway7

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Cellular Component (10)

Molecular Function (11)

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Biological Process (3)

KEGG (3)

Reactome (3)

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence137

Enzyme-Mediated Modification (68)

68 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PRKD1	PKD2	Q13563	S	910	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:20648625
PRKD1	AVP	P01185	S	910	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:18692497
PRKD1	AKT1	P31749	S	205	phosphorylation	KEA	KEA:17570479
PRKD1	ROS1	P08922	Y	95	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:26998193
PRKD1	ATM	Q13315	S	249	phosphorylation	KEA	KEA:17570479
PRKD1	PRKDC	P78527	S	249	phosphorylation	KEA	KEA:17570479
PRKD1	RPS6KA3	P51812	S	205	phosphorylation	KEA	KEA:17570479
PRKD1	RPS6KA3	P51812	S	249	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network (59)

59 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCD1	Q15139	M4K1	Q92918	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:24362026 PhosphoSite:15743830
KPCD1	Q15139	VASP	P50552	Yes	Yes	No	Sparser_ProtMapperPhosphoSite_norefiPTMnetProtMapperRLIMS-P_ProtMapperWangPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:16197368 PhosphoSite:25001901 PhosphoSite:7925440 ProtMapper:24401601 PhosphoSite:18195108 PhosphoSite:30814249 PhosphoSite:26784437 PhosphoSite:15265792 PhosphoSite:18559661 PhosphoSite:23611601 PhosphoSite:33393955 PhosphoSite:10922374 PhosphoSite:11748216 PhosphoSite:15178555 PhosphoSite:9685341 PhosphoSite:23846685 PhosphoSite:20958117 PhosphoSite:26336132 PhosphoSite:17684063 ProtMapper:23846685 PhosphoSite:16283430 PhosphoSite:16339778 PhosphoSite:11919161 PhosphoSite:18079117 PhosphoSite:25961942 PhosphoSite:25759389 PhosphoSite:33737052 PhosphoSite:27620165 ProtMapper:28051168
KPCD1	Q15139	TLR4	O00206	Yes	No	No	PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:20557879
KPCD1	Q15139	AP2A	P05549	Yes	No	No	PhosphoSite_MIMPMIMPPhosphoSite_norefiPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:18845787 ProtMapper:18845787
KPCD1	Q15139	DNM1L	O00429	Yes	No	No	Sparser_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23185298 PhosphoSite:28436948 ProtMapper:30567380 PhosphoSite:27540013 PhosphoSite:29348461 PhosphoSite:34589283 PhosphoSite:17553808 PhosphoSite:34038722 ProtMapper:29313986 PhosphoSite:31494243
KPCD1	Q15139	AP2B1	P63010	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:31492751
KPCD1	Q15139	ITB4	P16144	Yes	Yes	No	WangiPTMnetPhosphoSite	PhosphoSite:22357621 PhosphoSite:26580203
KPCD1	Q15139	SPHK2	Q9NRA0	Yes	No	No	PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:17635916
KPCD1	Q15139	MBP	P02686	Yes	Yes	No	PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetWangPhosphoSite	PhosphoSite:17939756

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	32560723

Sequence, Structure & Domains8

Sequences

Length

912

Mass

101,704

Sequence

MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL

Domain & Motif Annotations

Zinc Finger

146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2

Domain (FT)

422..541; PH; 583..839; Protein kinase

Region

377..402; Disordered

Protein Families (3)

Protein kinase superfamily
CAMK Ser/Thr protein kinase family
PKD subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.

Clinical Relevance8

Disease Involvement (2)

Disease variantEctodermal dysplasia

Related Diseases (2)

Solid tumour/cancer Urinary system disease

Biomarker

Investigative

Drugs (10)

UCN-01 GSK-690693 SOTRASTAURIN ARGIPRESSIN BRYOSTATIN MIDOSTAURIN RESVERATROL BRYOSTATIN 1 CEP-2563 QUERCETIN

Antibody (2)

CAB018367 HPA029834

Interaction Protein (3)

ENSG00000065054ENSG00000108561ENSG00000125148

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications16

PMID	Title	Abstract
38168906	Defining the relationship between cellular and extracellular vesicle (EV) content in breast cancer via an integrative multi-omic analysis.	No abstract available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available
39558134	Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis.	No abstract available
39940641	Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.	No abstract available
39948040	Quantitative proteomics identifies possible flow of metastatic cues between progressive stages of colorectal cancer via transfer of ceramide-dependent exosomal cargoes.	No abstract available
40748658	Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.	No abstract available

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