Protein detail

KPCD1

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Protein symbol KPCD1	UniProt ID Q15139	EVMP score 0.72
Frequency 16	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Basic Information

Protein Names

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Protein Class

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Ensembl

ENSG00000184304

Entrez Gene Symbol

PRKD1

Gene Synonym

PKC-muPKCMPKDPRKCM

Gene Description

Protein kinase D1

Chromosome

Position

29576479-30191898

Frequency

EVMP Score

0.72

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

68 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PRKD1	PRKCD	Q05655	S	738	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15024053 KEA:10867018 SIGNOR:15024053 ProtMapper:15024053 phosphoELM:15024053 KEA:11948398 KEA:15383279 ProtMapper:23109817 KEA:11741879
PRKD1	PRKCD	Q05655	S	412	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
PRKD1	PRKCD	Q05655	S	205	phosphorylation	PhosphoNetworks
PRKD1	PRKCD	Q05655	S	420	phosphorylation	PhosphoNetworks
PRKD1	PRKCD	Q05655	S	910	phosphorylation	PhosphoNetworks
PRKD1	PRKCD	Q05655	S	249	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PRKD1	ABL1	P00519	Y	502	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapper	KEA:12637538 ProtMapper:12637538 phosphoELM:12637538 SIGNOR:12637538
PRKD1	ABL1	P00519	Y	463	phosphorylation	BEL-Large-Corpus_ProtMapperSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:12637538 ProtMapper:15024053 ProtMapper:15212693 SIGNOR:12637538 KEA:12637538 ProtMapper:23329794 phosphoELM:12505989 phosphoELM:12637538 KEA:12505989 ProtMapper:12505989 ProtMapper:28174535
PRKD1	ABL1	P00519	Y	432	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapper	KEA:12637538 ProtMapper:12637538 phosphoELM:12637538 SIGNOR:12637538
PRKD1	ABL1	P00519	S	742	phosphorylation	RLIMS-P_ProtMapperProtMapper	ProtMapper:15024053

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Ligand-Receptor Signaling

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

59 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCD1	Q15139	M4K1	Q92918	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:24362026 PhosphoSite:15743830
KPCD1	Q15139	VASP	P50552	Yes	Yes	No	Sparser_ProtMapperPhosphoSite_norefiPTMnetProtMapperRLIMS-P_ProtMapperWangPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:16197368 PhosphoSite:25001901 PhosphoSite:7925440 ProtMapper:24401601 PhosphoSite:18195108 PhosphoSite:30814249 PhosphoSite:26784437 PhosphoSite:15265792 PhosphoSite:18559661 PhosphoSite:23611601 PhosphoSite:33393955 PhosphoSite:10922374 PhosphoSite:11748216 PhosphoSite:15178555 PhosphoSite:9685341 PhosphoSite:23846685 PhosphoSite:20958117 PhosphoSite:26336132 PhosphoSite:17684063 ProtMapper:23846685 PhosphoSite:16283430 PhosphoSite:16339778 PhosphoSite:11919161 PhosphoSite:18079117 PhosphoSite:25961942 PhosphoSite:25759389 PhosphoSite:33737052 PhosphoSite:27620165 ProtMapper:28051168
KPCD1	Q15139	TLR4	O00206	Yes	No	No	PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:20557879
KPCD1	Q15139	AP2A	P05549	Yes	No	No	PhosphoSite_MIMPMIMPPhosphoSite_norefiPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:18845787 ProtMapper:18845787
KPCD1	Q15139	DNM1L	O00429	Yes	No	No	Sparser_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23185298 PhosphoSite:28436948 ProtMapper:30567380 PhosphoSite:27540013 PhosphoSite:29348461 PhosphoSite:34589283 PhosphoSite:17553808 PhosphoSite:34038722 ProtMapper:29313986 PhosphoSite:31494243
KPCD1	Q15139	AP2B1	P63010	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:31492751
KPCD1	Q15139	ITB4	P16144	Yes	Yes	No	WangiPTMnetPhosphoSite	PhosphoSite:22357621 PhosphoSite:26580203
KPCD1	Q15139	SPHK2	Q9NRA0	Yes	No	No	PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:17635916
KPCD1	Q15139	MBP	P02686	Yes	Yes	No	PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetWangPhosphoSite	PhosphoSite:17939756

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Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	32560723

Sequence, Structure & Domains

Sequences

Length

912

Mass

101,704

Sequence

MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL

3D Structural Models

Domain & Motif Annotations

Zinc Finger

146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2

Domain (FT)

422..541; PH; 583..839; Protein kinase

Region

377..402; Disordered

Protein Families

Protein kinase superfamily
CAMK Ser/Thr protein kinase family
PKD subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.

Clinical Relevance

Disease Involvement

Disease variantEctodermal dysplasia

Related Diseases

Solid tumour/cancer Urinary system disease

Biomarker

Investigative

Drugs

UCN-01 GSK-690693 SOTRASTAURIN ARGIPRESSIN BRYOSTATIN MIDOSTAURIN RESVERATROL BRYOSTATIN 1 CEP-2563 QUERCETIN

Antibody

CAB018367 HPA029834

Interaction Protein

ENSG00000065054ENSG00000108561ENSG00000125148

Interaction Count

Interaction Dataset

intact_biogrid