Protein detail

KPCD1

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Entry name KPCD1	UniProt ID Q15139	EVMP confidence score 0.60
Supporting publications (n) 16	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Basic Information

Protein Names

Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Ensembl

ENSG00000184304

Entrez Gene Symbol

PRKD1

Gene Synonym (4)

PKC-muPKCMPKDPRKCM

Gene Description

Protein kinase D1

Chromosome

Position

29576479-30191898

Supporting publications (n)

EVMP confidence score

0.60

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Kinases:CAMK Ser/Thr protein kinases
Disease related genes

Cellular Component (10)

Molecular Function (11)

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Biological Process (3)

KEGG (3)

Reactome (3)

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence137

Enzyme-Mediated Modification (68)

68 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PRKD1	PRKD3	O94806	S	742	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
PRKD1	PRKACA	P17612	S	421	phosphorylation	PhosphoSite
PRKD1	PRKCE	Q02156	S	738	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
PRKD1	PRKCE	Q02156	S	742	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:12407104
PRKD1	PRKCE	Q02156	S	249	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PRKD1	PKD1	P98161	S	205	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:15755722 KEA:10867018
PRKD1	PKD1	P98161	S	910	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEA	KEA:10867018 KEA:16563698 KEA:11741879 KEA:10473617 ProtMapper:28577984
PRKD1	PKD1	P98161	S	738	phosphorylation	KEA	KEA:11741879
PRKD1	PKD1	P98161	S	742	phosphorylation	KEA	KEA:11741879
PRKD1	PRKCB	P05771	S	249	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

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Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Receiver
receptor	receptor	OmniPath	Yes
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath
receptor	receptor	scConnect	Yes

Regulatory Interaction Network (59)

59 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Database	References
KPCD1	Q15139	M4K1	Q92918	Yes		phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:24362026 PhosphoSite:15743830
KPCD1	Q15139	VASP	P50552	Yes	Yes	Sparser_ProtMapperPhosphoSite_norefiPTMnetProtMapperRLIMS-P_ProtMapperWangPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:16197368 PhosphoSite:25001901 PhosphoSite:7925440 ProtMapper:24401601 PhosphoSite:18195108 PhosphoSite:30814249 PhosphoSite:26784437 PhosphoSite:15265792 PhosphoSite:18559661 PhosphoSite:23611601 PhosphoSite:33393955 PhosphoSite:10922374 PhosphoSite:11748216 PhosphoSite:15178555 PhosphoSite:9685341 PhosphoSite:23846685 PhosphoSite:20958117 PhosphoSite:26336132 PhosphoSite:17684063 ProtMapper:23846685 PhosphoSite:16283430 PhosphoSite:16339778 PhosphoSite:11919161 PhosphoSite:18079117 PhosphoSite:25961942 PhosphoSite:25759389 PhosphoSite:33737052 PhosphoSite:27620165 ProtMapper:28051168
KPCD1	Q15139	TLR4	O00206	Yes		PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:20557879
KPCD1	Q15139	AP2A	P05549	Yes		PhosphoSite_MIMPMIMPPhosphoSite_norefiPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:18845787 ProtMapper:18845787
KPCD1	Q15139	DNM1L	O00429	Yes		Sparser_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23185298 PhosphoSite:28436948 ProtMapper:30567380 PhosphoSite:27540013 PhosphoSite:29348461 PhosphoSite:34589283 PhosphoSite:17553808 PhosphoSite:34038722 ProtMapper:29313986 PhosphoSite:31494243
KPCD1	Q15139	AP2B1	P63010	Yes		PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:31492751
KPCD1	Q15139	ITB4	P16144	Yes	Yes	WangiPTMnetPhosphoSite	PhosphoSite:22357621 PhosphoSite:26580203
KPCD1	Q15139	SPHK2	Q9NRA0	Yes		PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:17635916
KPCD1	Q15139	MBP	P02686	Yes	Yes	PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetWangPhosphoSite	PhosphoSite:17939756

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	32560723

Sequence, Structure & Domains

Sequences

Length

912

Mass

101,704

Sequence

MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL

Domain & Motif Annotations

Zinc Finger

146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2

Domain (FT)

422..541; PH; 583..839; Protein kinase

Region

377..402; Disordered

Protein Families (3)

Protein kinase superfamily
CAMK Ser/Thr protein kinase family
PKD subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.

Clinical Relevance

Disease Involvement (2)

Disease variantEctodermal dysplasia

Related Diseases (3)

Ectodermal dysplasia Solid tumour/cancer Urinary system disease

Biomarker

Investigative

Drugs (10)

UCN-01 GSK-690693 SOTRASTAURIN ARGIPRESSIN BRYOSTATIN MIDOSTAURIN RESVERATROL BRYOSTATIN 1 CEP-2563 QUERCETIN

Antibody (2)

CAB018367 HPA029834

Interaction Protein (3)

ENSG00000065054ENSG00000108561ENSG00000125148

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications16

PMID	Title	Related sentences
27863537	High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.	No related sentences available
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No related sentences available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No related sentences available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
30950185	Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer.	No related sentences available
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No related sentences available
32944193	Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties.	No related sentences available
33919183	Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry.	No related sentences available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No related sentences available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No related sentences available

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