Protein detail
KPCD1
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Entry name KPCD1 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 16 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (7)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
PKC-muPKCMPKDPRKCM
Gene Description
Protein kinase D1
Chromosome
14
Position
29576479-30191898
Supporting publications (n)
16
EVMP confidence score
0.72
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (7)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Cellular Component (10)
Molecular Function (11)
- GO:0004674 protein serine/threonine kinase activity
- GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0031072 heat shock protein binding
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0106310 protein serine kinase activity
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Biological Process (3)
KEGG (3)
Reactome (3)
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence137
Enzyme-Mediated Modification (68)
68 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PRKD1 | PRKCG | P05129 | S | 249 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PRKD1 | PRRT2 | Q7Z6L0 | S | 910 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:10644509 |
| PRKD1 | PRRT2 | Q7Z6L0 | S | 738 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:12407104 |
| PRKD1 | POMC | P01189 | S | 910 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:19961896 |
| PRKD1 | DAPK1 | P53355 | S | 910 | phosphorylation | Sparser_ProtMapperProtMapper | |
| PRKD1 | AGT | P01019 | S | 910 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:19961896 |
| PRKD1 | WNT3A | P56704 | S | 738 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:15886323 |
| PRKD1 | SPG7 | Q9UQ90 | S | 738 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25000413 |
| PRKD1 | SPG7 | Q9UQ90 | S | 742 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25000413 |
| PRKD1 | TNF | P01375 | S | 738 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25000413 |
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network (59)
59 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PKHUO | C0HM02 | KPCD1 | Q15139 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDKinexus_KEAPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos | KEA:15024053HPRD-phos:10867018KEA:10867018ProtMapper:10867018phosphoELM:11741879phosphoELM:15024053KEA:11948398KEA:15383279SIGNOR:10197446HPRD:10867018HPRD-phos:11741879KEA:11741879ProtMapper:11741879ProtMapper:10197446HPRD:11741879 |
| KPCD1 | Q15139 | OSBP1 | P22059 | Yes | No | Yes | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | ProtMapper:23830809ProtMapper:21152398SIGNOR:21285358ProtMapper:21285358ProtMapper:22875984ProtMapper:20444975 |
| KPCD1 | Q15139 | COF1 | P23528 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_ProtMapper | SIGNOR:19329994 |
| KPCD1 | Q15139 | PAK4 | O96013 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:26218748PhosphoSite:11668177SIGNOR:24840177ProtMapper:26068882PhosphoSite:27903866 |
| SRC | P12931 | KPCD1 | Q15139 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapper | ProtMapper:12637538SIGNOR:12637538KEA:17804414KEA:12637538PhosphoSite:28842658ProtMapper:28361035ProtMapper:29933512ProtMapper:12505989HPRD:12637538ProtMapper:28174535PhosphoSite:17804414ProtMapper:17804414SIGNOR:17804414phosphoELM:17804414 |
| KPCD1 | Q15139 | KAT7 | O95251 | Yes | Yes | No | PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:33014433PhosphoSite:34535630SIGNOR:33014433 |
| KPCD1 | Q15139 | PTH2 | Q9Y3E5 | Yes | Yes | No | WangPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:18703509SIGNOR:18703509 |
| KPCD1 | Q15139 | PI42A | P48426 | Yes | No | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:16563698SIGNOR:16563698 |
| KPCD1 | Q15139 | KDIS | Q9ULH0 | Yes | Yes | No | WangPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEASIGNOR_ProtMapperHPRD-phos | HPRD-phos:10998417ProtMapper:18578522SIGNOR:10998417KEA:10998417HPRD-phos:18578522ProtMapper:10998417ProtMapper:20068231HPRD:10998417HPRD-phos:20068231HPRD-phos:18669648ProtMapper:18669648 |
| KPCD1 | Q15139 | PI4KB | Q9UBF8 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16912074PhosphoSite:33090289PhosphoSite:26459638PhosphoSite:28495678SIGNOR:16912074ProtMapper:23572552 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 32560723 |
Sequence, Structure & Domains8
Sequences
Length
912
Mass
101,704
Sequence
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
Domain & Motif Annotations
Zinc Finger
146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2
Domain (FT)
422..541; PH; 583..839; Protein kinase
Region
377..402; Disordered
Protein Families (3)
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- PKD subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Clinical Relevance8
Disease Involvement (2)
Disease variantEctodermal dysplasia
Related Diseases (2)
Biomarker
Investigative
Drugs (10)
Interaction Protein (3)
ENSG00000065054ENSG00000108561ENSG00000125148
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications16
| PMID | Title | Abstract |
|---|---|---|
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No abstract available |
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 32944193 | Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties. | No abstract available |
| 33919183 | Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry. | No abstract available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No abstract available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No abstract available |
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