Protein detail
KPCD1
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein symbol KPCD1 | UniProt ID | EVMP score 0.72 |
Frequency 16 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Basic Information
Protein Names
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
PKC-muPKCMPKDPRKCM
Gene Description
Protein kinase D1
Chromosome
14
Position
29576479-30191898
Frequency
16
EVMP Score
0.72
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Cellular Component
Molecular Function
- GO:0004674 protein serine/threonine kinase activity
- GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0031072 heat shock protein binding
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0106310 protein serine kinase activity
- GO:0141038 phosphatidylinositol 3-kinase activator activity
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
68 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PRKD1 | PRKCG | P05129 | S | 249 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PRKD1 | PRRT2 | Q7Z6L0 | S | 910 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:10644509 |
| PRKD1 | PRRT2 | Q7Z6L0 | S | 738 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:12407104 |
| PRKD1 | POMC | P01189 | S | 910 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:19961896 |
| PRKD1 | DAPK1 | P53355 | S | 910 | phosphorylation | Sparser_ProtMapperProtMapper | |
| PRKD1 | AGT | P01019 | S | 910 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:19961896 |
| PRKD1 | WNT3A | P56704 | S | 738 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:15886323 |
| PRKD1 | SPG7 | Q9UQ90 | S | 738 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25000413 |
| PRKD1 | SPG7 | Q9UQ90 | S | 742 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25000413 |
| PRKD1 | TNF | P01375 | S | 738 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25000413 |
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
59 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCD1 | Q15139 | ARFP1 | P53367 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:23695357PhosphoSite:25789876ProtMapper:22981988ProtMapper:25789876SIGNOR:23695357 |
| KPCD1 | Q15139 | CADH1 | P12830 | Yes | Yes | No | WangSPIKE_LCSIGNOR | SIGNOR:15695390SPIKE_LC:15695390 |
| KPCD1 | Q15139 | KCNH2 | Q12809 | Yes | No | Yes | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:29949809SIGNOR:29949809 |
| KPCD1 | Q15139 | PKD2 | Q13563 | Yes | Yes | No | iPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapper | SIGNOR:20881056ProtMapper:20881056 |
| KPCD1 | Q15139 | PTN7 | P35236 | Yes | Yes | No | SIGNOR | SIGNOR:16479000 |
| KPCD1 | Q15139 | HDAC5 | Q9UQL6 | Yes | No | Yes | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEABioGRIDHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | ProtMapper:19655095ProtMapper:24219103SIGNOR:15367659HPRD:15367659KEA:15367659SIGNOR:22865920ProtMapper:11081517HPRD:11114197KEA:11114197HPRD:11081517ProtMapper:20621068ProtMapper:28681592BioGRID:26137861ProtMapper:25514029ProtMapper:22865920ProtMapper:25362149ProtMapper:21357900ProtMapper:31784580ProtMapper:15367659KEA:11081517ProtMapper:32683534ProtMapper:11114197 |
| KPCD1 | Q15139 | CAC1C | Q13936 | Yes | Yes | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:22100296PhosphoSite:22100296PhosphoSite:22310722PhosphoSite:31759979SIGNOR:22100296 |
| KPCD1 | Q15139 | REM1 | O75628 | Yes | Yes | No | Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:22076634SIGNOR:22076634ProtMapper:22076634 |
| KPCD1 | Q15139 | TLR5 | O60602 | Yes | Yes | No | WangPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperdbPTMInnateDBSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | dbPTM:17442957SIGNOR:17442957InnateDB:17442957ProtMapper:17442957 |
| KPCD1 | Q15139 | RHG07 | Q96QB1 | Yes | No | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:21087603SIGNOR:21087603PhosphoSite:21087603 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 32560723 |
Sequence, Structure & Domains
Sequences
Length
912
Mass
101,704
Sequence
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
3D Structural Models
Domain & Motif Annotations
Zinc Finger
146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2
Domain (FT)
422..541; PH; 583..839; Protein kinase
Region
377..402; Disordered
Protein Families
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- PKD subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Clinical Relevance
Disease Involvement
Disease variantEctodermal dysplasia
Related Diseases
Biomarker
Investigative
Drugs
Interaction Protein
ENSG00000065054ENSG00000108561ENSG00000125148
Interaction Count
3
Interaction Dataset
intact_biogrid