Protein detail
KPCD1
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein symbol KPCD1 | UniProt ID | EVMP score 0.72 |
Frequency 16 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Basic Information
Protein Names
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
PKC-muPKCMPKDPRKCM
Gene Description
Protein kinase D1
Chromosome
14
Position
29576479-30191898
Frequency
16
EVMP Score
0.72
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Cellular Component
Molecular Function
- GO:0004674 protein serine/threonine kinase activity
- GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0031072 heat shock protein binding
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0106310 protein serine kinase activity
- GO:0141038 phosphatidylinositol 3-kinase activator activity
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
68 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PRKD1 | TNF | P01375 | S | 742 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25000413 |
| PRKD1 | EDN1 | P05305 | S | 738 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:24219103 |
| PRKD1 | EDN1 | P05305 | S | 742 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:24219103 |
| PRKD1 | EGF | P01133 | S | 738 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25000413 |
| PRKD1 | EGF | P01133 | S | 742 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:25000413 |
| PRKD1 | HMOX1 | P09601 | S | 738 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:16814111 |
| PRKD1 | HMOX1 | P09601 | S | 742 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:16814111 |
| PRKD1 | F2 | P00734 | S | 738 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:16814111 |
| PRKD1 | F2 | P00734 | S | 742 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:16814111 |
| PRKD1 | BCR | P11274 | S | 910 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:10859332 |
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
59 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK13 | O15264 | KPCD1 | Q15139 | Yes | No | Yes | dbPTMSPIKE_LCiPTMnetSIGNOR | SIGNOR:19135240dbPTM:19369195dbPTM:19413330SPIKE_LC:19135240dbPTM:19135240 |
| KPCD1 | Q15139 | CERT | Q9Y5P4 | Yes | No | Yes | Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperReactome_ProtMapperdbPTMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:19005213ProtMapper:17591919dbPTM:17591919PhosphoSite:23676904PhosphoSite:29541394PhosphoSite:29848549PhosphoSite:17591919PhosphoSite:28652409ProtMapper:22226883ProtMapper:25889812SIGNOR:17591919ProtMapper:23608234PhosphoSite:17442665ProtMapper:19005213 |
| KPCD1 | Q15139 | CTNB1 | P35222 | Yes | Yes | No | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:22511927ProtMapper:29108267PhosphoSite:29108267SIGNOR:19141652ProtMapper:19141652ProtMapper:26895471 |
| KPCD1 | Q15139 | NOS1 | P29475 | Yes | Yes | No | Lit-BM-17SIGNORSparser_ProtMapperProtMapper | ProtMapper:24740233Lit-BM-17:24740233SIGNOR:24740233 |
| KPCD1 | Q15139 | CXCR4 | P61073 | Yes | No | Yes | RLIMS-P_ProtMapperREACH_ProtMapperSIGNORProtMapper | SIGNOR:27127886ProtMapper:27127886 |
| KPCD1 | Q15139 | DYL1 | P63167 | Yes | No | Yes | SIGNOR | SIGNOR:21087603 |
| KPCD1 | Q15139 | AP2B | Q92481 | Yes | No | Yes | REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper | ProtMapper:31492751SIGNOR:31492751 |
| KPCD1 | Q15139 | NLRP3 | Q96P20 | Yes | Yes | No | REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper | ProtMapper:33627128ProtMapper:33850310ProtMapper:31036962SIGNOR:28716882ProtMapper:30844378 |
| KPCD1 | Q15139 | BAD | Q92934 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:20179209PhosphoSite:12531792SIGNOR:20179209 |
| KPCD1 | Q15139 | ST17B | O94768 | Yes | Yes | No | SIGNOR | SIGNOR:21148796 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 32560723 |
Sequence, Structure & Domains
Sequences
Length
912
Mass
101,704
Sequence
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
3D Structural Models
Domain & Motif Annotations
Zinc Finger
146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2
Domain (FT)
422..541; PH; 583..839; Protein kinase
Region
377..402; Disordered
Protein Families
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- PKD subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Clinical Relevance
Disease Involvement
Disease variantEctodermal dysplasia
Related Diseases
Biomarker
Investigative
Drugs
Interaction Protein
ENSG00000065054ENSG00000108561ENSG00000125148
Interaction Count
3
Interaction Dataset
intact_biogrid