Protein detail
KPCD1
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Entry name KPCD1 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 16 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (7)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
PKC-muPKCMPKDPRKCM
Gene Description
Protein kinase D1
Chromosome
14
Position
29576479-30191898
Supporting publications (n)
16
EVMP confidence score
0.60
Fluorescence & Localization
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (7)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Cellular Component (10)
Molecular Function (11)
- GO:0004674 protein serine/threonine kinase activity
- GO:0004697 diacylglycerol-dependent serine/threonine kinase activity
- GO:0005080 protein kinase C binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016301 kinase activity
- GO:0031072 heat shock protein binding
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0106310 protein serine kinase activity
Page 1 of 2
Biological Process (3)
KEGG (3)
Reactome (3)
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence137
Enzyme-Mediated Modification (68)
68 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PRKD1 | PKD2 | Q13563 | S | 910 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:20648625 |
| PRKD1 | AVP | P01185 | S | 910 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:18692497 |
| PRKD1 | AKT1 | P31749 | S | 205 | phosphorylation | KEA | KEA:17570479 |
| PRKD1 | ROS1 | P08922 | Y | 95 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:26998193 |
| PRKD1 | ATM | Q13315 | S | 249 | phosphorylation | KEA | KEA:17570479 |
| PRKD1 | PRKDC | P78527 | S | 249 | phosphorylation | KEA | KEA:17570479 |
| PRKD1 | RPS6KA3 | P51812 | S | 205 | phosphorylation | KEA | KEA:17570479 |
| PRKD1 | RPS6KA3 | P51812 | S | 249 | phosphorylation | KEA | KEA:17570479 |
Page 7 of 7Previous
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| receptor | receptor | scConnect | Yes |
Regulatory Interaction Network (59)
59 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KPCD1 | Q15139 | ARFP1 | P53367 | Yes | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:23695357PhosphoSite:25789876ProtMapper:22981988ProtMapper:25789876SIGNOR:23695357 | |
| KPCD1 | Q15139 | CADH1 | P12830 | Yes | Yes | WangSPIKE_LCSIGNOR | SIGNOR:15695390SPIKE_LC:15695390 | |
| KPCD1 | Q15139 | KCNH2 | Q12809 | Yes | Yes | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:29949809SIGNOR:29949809 | |
| KPCD1 | Q15139 | PKD2 | Q13563 | Yes | Yes | iPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapper | SIGNOR:20881056ProtMapper:20881056 | |
| KPCD1 | Q15139 | PTN7 | P35236 | Yes | Yes | SIGNOR | SIGNOR:16479000 | |
| KPCD1 | Q15139 | HDAC5 | Q9UQL6 | Yes | Yes | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEABioGRIDHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | ProtMapper:19655095ProtMapper:24219103SIGNOR:15367659HPRD:15367659KEA:15367659SIGNOR:22865920ProtMapper:11081517HPRD:11114197KEA:11114197HPRD:11081517ProtMapper:20621068ProtMapper:28681592BioGRID:26137861ProtMapper:25514029ProtMapper:22865920ProtMapper:25362149ProtMapper:21357900ProtMapper:31784580ProtMapper:15367659KEA:11081517ProtMapper:32683534ProtMapper:11114197 | |
| KPCD1 | Q15139 | CAC1C | Q13936 | Yes | Yes | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:22100296PhosphoSite:22100296PhosphoSite:22310722PhosphoSite:31759979SIGNOR:22100296 | |
| KPCD1 | Q15139 | REM1 | O75628 | Yes | Yes | Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:22076634SIGNOR:22076634ProtMapper:22076634 | |
| KPCD1 | Q15139 | TLR5 | O60602 | Yes | Yes | WangPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperdbPTMInnateDBSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper | dbPTM:17442957SIGNOR:17442957InnateDB:17442957ProtMapper:17442957 | |
| KPCD1 | Q15139 | RHG07 | Q96QB1 | Yes | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:21087603SIGNOR:21087603PhosphoSite:21087603 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Western blotting | 1 | 32560723 |
Sequence, Structure & Domains
Sequences
Length
912
Mass
101,704
Sequence
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEETEMKALGERVSIL
Domain & Motif Annotations
Zinc Finger
146..196; Phorbol-ester/DAG-type 1; 270..320; Phorbol-ester/DAG-type 2
Domain (FT)
422..541; PH; 583..839; Protein kinase
Region
377..402; Disordered
Protein Families (3)
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- PKD subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Clinical Relevance
Disease Involvement (2)
Disease variantEctodermal dysplasia
Related Diseases (3)
Biomarker
Investigative
Drugs (10)
Interaction Protein (3)
ENSG00000065054ENSG00000108561ENSG00000125148
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications16
| PMID | Title | Related sentences |
|---|---|---|
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No related sentences available |
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No related sentences available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No related sentences available |
| 32944193 | Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties. | No related sentences available |
| 33919183 | Multiple-Cycle Polymeric Extracellular Vesicle Precipitation and Its Evaluation by Targeted Mass Spectrometry. | No related sentences available |
| 34817906 | Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform. | No related sentences available |
| 37786918 | Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples. | No related sentences available |
Page 1 of 2Next