Protein detail

PTPRR

Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1)

Protein symbol PTPRR	UniProt ID Q15256	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1)

Protein Class

EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function

Enzymes
Predicted secreted proteins
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Transmembrane

228..248; Helical

Transmembrane Count

Ensembl

ENSG00000153233

Entrez Gene Symbol

PTPRR

Gene Synonym

EC-PTPPCPTP1PTP-SLPTPBR7PTPRQ

Gene Description

Protein tyrosine phosphatase receptor type R

Chromosome

Position

70638073-70920738

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificCardiomyocytesSingle-Nuclei Brain SpecificBergmann glia

Function & Pathway

Protein Function

Enzymes
Predicted secreted proteins
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04010 MAPK signaling pathway

Mediation Categories

Metabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

12 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PTPRR	PRKACA	P17612	S	339	phosphorylation	MIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper	SIGNOR:10601328 KEA:10601328 ProtMapper:10601328
PTPRR	PRKACA	P17612	S	94	phosphorylation	KEA	KEA:10601328
PTPRR	MAPK1	P28482	T	361	phosphorylation	Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEASIGNOR_ProtMapper	KEA:11493009 KEA:9857190 ProtMapper:11493009 SIGNOR:11493009
PTPRR	MAPK1	P28482	T	116	phosphorylation	KEA	KEA:11493009
PTPRR	MAPK1	P28482	Y	370	phosphorylation	KEA	KEA:18083107
PTPRR	MAPK1	P28482	Y	44	phosphorylation	KEA	KEA:CST-PHOSPHOSITE-5539963
PTPRR	MAPK1	P28482	Y	62	phosphorylation	KEA	KEA:CST-PHOSPHOSITE-5539967
PTPRR	MAPK3	P27361	T	116	phosphorylation	KEA	KEA:11493009
PTPRR	MAPK3	P27361	Y	370	phosphorylation	KEA	KEA:18083107
PTPRR	MAPK3	P27361	T	361	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper	KEA:11493009 KEA:9857190 ProtMapper:11493009 SIGNOR:11493009

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Ligand-Receptor Signaling

31 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Surfaceome	No	Yes	Yes	Yes	No
receptortypephosphatases	receptor	Surfaceome	No	Yes	Yes	Yes	No
receptor	receptor	OmniPath	No	Yes	Yes	Yes	No
extracellular	extracellular	OmniPath	No	No	Yes	Yes	No
intracellular	intracellular	ComPPI	No	No	Yes	Yes	No
intracellular	intracellular	GO_Intercell	No	No	Yes	Yes	No
intracellular	intracellular	UniProt_location	No	No	Yes	Yes	No
intracellular	intracellular	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	Yes	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	Yes	Yes	No

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Regulatory Interaction Network

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MK03	P27361	PTPRR	Q15256	Yes	Yes	No	WangPhosphoSite_MIMPMIMPNetPathHPRD_MIMPPhosphoPointSIGNORProtMapperHPRDHINTKEAKinexus_KEAHPRD_KEASIGNOR_ProtMapperSPIKESPIKE_LC	KEA:11493009 SPIKE_LC:9857190 HPRD:10419510 ProtMapper:11493009 HINT:9857190 KEA:18083107 SPIKE:9857190 NetPath:9857190 HINT:10419510 HPRD:10066421 SIGNOR:11493009 KEA:9857190 HPRD:9857190
MK01	P28482	PTPRR	Q15256	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAHuRILit-BM-17HPRDKinexus_KEAIntActWangPhosphoSite_MIMPMIMPPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperNetPathSPIKE_LCSPIKE	KEA:11493009 HINT:9857190 NetPath:9857190 IntAct:10601328 IntAct:25241761 SPIKE:9857190 HINT:10419510 SIGNOR:11493009 KEA:9857190 SPIKE_LC:9857190 Lit-BM-17:26186194 HPRD:10419510 ProtMapper:11493009 Lit-BM-17:10601328 KEA:18083107 HINT:16148006 HINT:33961781 Lit-BM-17:25241761 HINT:10601328 HPRD:16148006 HPRD:9857190 Lit-BM-17:9857190
PTPRR	Q15256	MK01	P28482	Yes	No	Yes	WangNetPathSIGNORProtMapperHPRDHINTHuRIIntActSIGNOR_ProtMapperLit-BM-17SPIKESPIKE_LC	HINT:9857190 NetPath:9857190 IntAct:10601328 IntAct:25241761 SPIKE:9857190 HINT:10419510 SIGNOR:11493009 SPIKE_LC:9857190 Lit-BM-17:26186194 HPRD:10419510 ProtMapper:11493009 Lit-BM-17:10601328 HINT:16148006 HINT:33961781 Lit-BM-17:25241761 HINT:10601328 HPRD:16148006 HPRD:9857190 Lit-BM-17:9857190
PTPRR	Q15256	STAT3	P40763	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:17360477 SIGNOR:17360477
PTPRR	Q15256	PAXI	P49023	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:20133777 SIGNOR:20133777
PTPRR	Q15256	MK14	Q16539	Yes	No	Yes	SIGNORELMHINTIntActDIPWang	HINT:23932588 IntAct:10601328 ELM:23932588 HINT:10601328 IntAct:23932588 SIGNOR:11711538 DIP:23932588 HINT:33961781
KAPCA	P17612	PTPRR	Q15256	Yes	No	Yes	MIMPHPRD_MIMPPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper	HPRD:10601328 SIGNOR:10601328 ProtMapper:10601328 KEA:10601328 KEA:11749379
PTPRR	Q15256	MK07	Q13164	Yes	No	Yes	NetPathSIGNORProtMapperDEPODHPRDCancerCellMapSIGNOR_ProtMapper	SIGNOR:12042304 CancerCellMap:12042304 DEPOD:12042304 NetPath:12042304 HPRD:12042304 ProtMapper:12042304

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DUSP16 HOXA10 HOXA9 HOXB9 MAPK11 MAPK14 MAPKAPK3 MKNK1 MKNK2 MYLK2 MYLK3 OBSL1 PTPRR RHBDF1 RPS6KA4 RPS6KA5 SLX4IP	O75147 O75582 O75676 P17482 P31260 P31269 Q15256 Q15759 Q16539 Q16644 Q32MK0 Q5VYV7 Q96CC6 Q9BUB5 Q9BY84 Q9H1R3 Q9HBH9	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western BlottingMass Spectrometry	1	36573687

Sequence, Structure & Domains

Sequences

Length

657

Mass

73,834

Sequence

MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=Alpha; IsoId=Q15256-1; Sequence=Displayed; Name=Gamma; IsoId=Q15256-3; Sequence=VSP_005156; Name=Delta; IsoId=Q15256-4; Sequence=VSP_005155, VSP_005158; Name=4; IsoId=Q15256-5; Sequence=VSP_046352, VSP_046353

Alternative Sequence

1..245; Missing (in isoform Gamma); 1..206; Missing (in isoform Delta); 1..7; MRRAVCF -> MQSISKQ (in isoform 4); 8..119; Missing (in isoform 4); 207..209; SPE -> MNQ (in isoform Delta)

3D Structural Models

Helix

380..386; 390..398; 407..409; 415..418; 428..430; 442..445; 455..457; 470..472; 473..483; 562..576; 593..611; 616..626; 634..648

Beta Strand

431..433; 446..452; 461..465; 487..492; 494..499; 507..512; 515..524; 529..537; 540..549; 554..556; 584..587; 589..592; 612..614

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

393..647; Tyrosine-protein phosphatase

Protein Families

Protein-tyrosine phosphatase family
Receptor class 7 subfamily

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.

Clinical Relevance

Antibody

CAB011461 HPA011851 HPA071067

Interaction Protein

ENSG00000100030ENSG00000112062ENSG00000141736ENSG00000171105

Interaction Count

Interaction Dataset

intact_biogrid