Protein detail

PTPRK

Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)

Protein symbol PTPRK	UniProt ID Q15262	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)

Protein Class

Cancer-related genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases
Cancer-related genes

Transmembrane

753..774; Helical

Transmembrane Count

Ensembl

ENSG00000152894

Entrez Gene Symbol

PTPRK

Gene Synonym

R-PTP-kappa

Gene Description

Protein tyrosine phosphatase receptor type K

Chromosome

Position

127968785-128520616

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificEpicardial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases
Cancer-related genes

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

51 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No

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Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTPRK	Q15262	PROM1	O43490	Yes	No	Yes	SIGNOR	SIGNOR:30947381
PTPRK	Q15262	EGFR	P00533	Yes	No	Yes	WangSIGNORProtMapperDEPODSIGNOR_ProtMapperREACH_ProtMapper	SIGNOR:16263724 DEPOD:16263724 ProtMapper:16263724 ProtMapper:19236842
PTPRK	Q15262	STAT3	P40763	Yes	No	Yes	SIGNOR	SIGNOR:25612622
PTPRK	Q15262	ZNRF3	Q9ULT6	Yes	Yes	No	SIGNOR	SIGNOR:31934854

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PTPRK	Q15262	2	PDB	PDB:8a1f
	AMIGO3 ARSG PTPRK	Q15262 Q86WK7 Q96EG1	0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	37427430

Sequence, Structure & Domains

Sequences

Length

1,439

Mass

162,102

Sequence

MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q15262-1; Sequence=Displayed; Name=2; IsoId=Q15262-2; Sequence=VSP_024819; Name=3; IsoId=Q15262-3; Sequence=VSP_024819, VSP_042049; Name=4; IsoId=Q15262-4; Sequence=VSP_024819, VSP_054480, VSP_042049

Alternative Sequence

732; A -> AA (in isoform 2, isoform 3 and isoform 4); 831; Y -> LPNDPLVPTAVLVPITD (in isoform 4); 946; I -> IDIWLYR (in isoform 3 and isoform 4)

3D Structural Models

Turn

1150..1153

Helix

43..45; 82..84; 262..264; 869..871; 872..879; 887..892; 903..906; 908..913; 923..925; 936..939; 963..965; 966..976; 1058..1070; 1087..1105; 1110..1120; 1128..1144

Beta Strand

53..55; 58..60; 62..64; 75..81; 90..94; 105..113; 121..129; 138..143; 150..156; 164..172; 179..190; 204..207; 212..219; 227..232; 242..244; 247..257; 266..274; 277..280; 284..289; 293..296; 299..303; 305..311; 316..319; 325..332; 338..342; 345..352; 358..366; 380..383; 883..885; 942..948; 951..958; 980..983; 987..989; 1001..1006; 1009..1018; 1020..1031; 1038..1045; 1050..1053; 1078..1081; 1083..1086; 1106..1108

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

31..194; MAM; 196..281; Ig-like C2-type; 294..389; Fibronectin type-III 1; 392..488; Fibronectin type-III 2; 491..595; Fibronectin type-III 3; 597..680; Fibronectin type-III 4; 887..1141; Tyrosine-protein phosphatase 1; 1173..1435; Tyrosine-protein phosphatase 2

Protein Families

Protein-tyrosine phosphatase family
Receptor class 2B subfamily

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genes

Antibody

HPA054056 HPA054822

Interaction Protein

ENSG00000113083ENSG00000167900

Interaction Count

Interaction Dataset

intact_biogrid