Protein detail
PTPRK
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)
Protein symbol PTPRK | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)
Protein Class
Cancer-related genesEnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
- Cancer-related genes
Transmembrane
753..774; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
R-PTP-kappa
Gene Description
Protein tyrosine phosphatase receptor type K
Chromosome
6
Position
127968785-128520616
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEpicardial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
- Cancer-related genes
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
51 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRK | Q15262 | PROM1 | O43490 | Yes | No | Yes | SIGNOR | SIGNOR:30947381 |
| PTPRK | Q15262 | EGFR | P00533 | Yes | No | Yes | WangSIGNORProtMapperDEPODSIGNOR_ProtMapperREACH_ProtMapper | SIGNOR:16263724DEPOD:16263724ProtMapper:16263724ProtMapper:19236842 |
| PTPRK | Q15262 | STAT3 | P40763 | Yes | No | Yes | SIGNOR | SIGNOR:25612622 |
| PTPRK | Q15262 | ZNRF3 | Q9ULT6 | Yes | Yes | No | SIGNOR | SIGNOR:31934854 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 37427430 |
Sequence, Structure & Domains
Sequences
Length
1,439
Mass
162,102
Sequence
MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q15262-1; Sequence=Displayed; Name=2; IsoId=Q15262-2; Sequence=VSP_024819; Name=3; IsoId=Q15262-3; Sequence=VSP_024819, VSP_042049; Name=4; IsoId=Q15262-4; Sequence=VSP_024819, VSP_054480, VSP_042049
Alternative Sequence
732; A -> AA (in isoform 2, isoform 3 and isoform 4); 831; Y -> LPNDPLVPTAVLVPITD (in isoform 4); 946; I -> IDIWLYR (in isoform 3 and isoform 4)
3D Structural Models
Turn
1150..1153
Helix
43..45; 82..84; 262..264; 869..871; 872..879; 887..892; 903..906; 908..913; 923..925; 936..939; 963..965; 966..976; 1058..1070; 1087..1105; 1110..1120; 1128..1144
Beta Strand
53..55; 58..60; 62..64; 75..81; 90..94; 105..113; 121..129; 138..143; 150..156; 164..172; 179..190; 204..207; 212..219; 227..232; 242..244; 247..257; 266..274; 277..280; 284..289; 293..296; 299..303; 305..311; 316..319; 325..332; 338..342; 345..352; 358..366; 380..383; 883..885; 942..948; 951..958; 980..983; 987..989; 1001..1006; 1009..1018; 1020..1031; 1038..1045; 1050..1053; 1078..1081; 1083..1086; 1106..1108
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
31..194; MAM; 196..281; Ig-like C2-type; 294..389; Fibronectin type-III 1; 392..488; Fibronectin type-III 2; 491..595; Fibronectin type-III 3; 597..680; Fibronectin type-III 4; 887..1141; Tyrosine-protein phosphatase 1; 1173..1435; Tyrosine-protein phosphatase 2
Protein Families
- Protein-tyrosine phosphatase family
- Receptor class 2B subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.