Protein detail

TLR1

Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)

Entry name TLR1	UniProt ID Q15399	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)

Protein Function (3)

Predicted intracellular proteins
CD markers
Transporters:Accessory Factors Involved in Transport

Transmembrane

581..601; Helical

Transmembrane Count

Ensembl

ENSG00000174125

Entrez Gene Symbol

TLR1

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization2

Cell SpecificExtravillous trophoblastsBlood Cell Specificintermediate monocyte

Function & Pathway7

Protein Function (3)

Predicted intracellular proteins
CD markers
Transporters:Accessory Factors Involved in Transport

Cellular Component (7)

Molecular Function (7)

Biological Process (3)

KEGG (2)

Reactome (18)

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Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence49

Ligand-Receptor Signaling (38)

38 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
toll_like	receptor	Almen2009	No	Yes	No	Yes	No
toll	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No

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Protein Complex Composition (10)

10 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Ndc80p complex	NDC80 NIN NINL NUF2 TLR1	O14777 Q15399 Q8N4C6 Q9BZD4 Q9Y2I6	1:1:1:1:1	Compleat	Compleat:HC2762	11266451
TLR1-TLR10 toll-like receptor complex	TLR1 TLR10	Q15399 Q9BXR5	1:1	ComplexPortal		34180006 14755292 33576548
	CDC5L DHX16 EFTUD2 PLRG1 PRPF19 PRPF8 SF3A2 SF3B1 SF3B2 SF3B3 SNRNP200 SNW1 SRRM2 TLR1 TRAP1	O43660 O60231 O75533 O75643 Q12931 Q13435 Q13573 Q15029 Q15393 Q15399 Q15428 Q6P2Q9 Q99459 Q9UMS4 Q9UQ35	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6347
	CDC5L DHX16 DHX36 EFTUD2 PLRG1 PRPF19 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SNW1 SRRM2 TLR1	O43660 O60231 O75533 Q12874 Q13435 Q13573 Q15029 Q15393 Q15399 Q15428 Q15459 Q99459 Q9H2U1 Q9UMS4 Q9UQ35	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6409
	CDC5L EFTUD2 PLRG1 PRPF19 PRPF8 SF3A2 SF3B1 SF3B2 SF3B3 SNRNP200 SNRPB SNW1 SRRM2 TLR1 TRAP1	O43660 O75533 O75643 P14678 Q12931 Q13435 Q13573 Q15029 Q15393 Q15399 Q15428 Q6P2Q9 Q99459 Q9UMS4 Q9UQ35	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7656
	TLR1 TRAP1 VIPAS39 VPS33B	Q12931 Q15399 Q9H267 Q9H9C1	1:1:1:1	NetworkBlastCompleat	Compleat:HC9041
	ALDH16A1 IQUB TLR1 TLR6	Q15399 Q8IZ83 Q8NA54 Q9Y2C9	0:0:0:0	hu.MAP2
	IQUB TLR1 TLR6	Q15399 Q8NA54 Q9Y2C9	0:0:0	hu.MAP2
	TLR1 TLR6	Q15399 Q9Y2C9	0:0	hu.MAP2
	TLR10	Q9BXR5	2	PDB	PDB:2j67

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blotting	1	32560723

Sequence, Structure & Domains12

Sequences

Length

786

Mass

90,291

Sequence

MTSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAKK

3D Structural Models

Turn

173..178; 227..230; 362..367; 487..491; 517..520; 529..531; 661..663; 669..671

Helix

62..65; 86..89; 133..137; 153..159; 181..184; 231..238; 239..242; 258..269; 317..324; 387..394; 414..416; 437..441; 462..466; 504..516; 536..538; 628..630; 645..647; 648..653; 655..660; 679..688; 699..704; 706..713; 736..738; 744..751; 762..764; 765..777

Beta Strand

28..30; 48..51; 73..75; 83..85; 97..99; 107..109; 117..120; 143..150; 164..171; 189..195; 198..200; 214..218; 221..223; 248..257; 274..285; 301..309; 329..336; 352..354; 376..378; 402..404; 427..429; 449..451; 472..474; 521..523; 631..633; 637..642; 666..668; 690..698; 726..732; 755..757

3D Structure

NMR spectroscopy (1); X-ray crystallography (5)

Domain & Motif Annotations

Repeat

54..77; LRR 1; 78..101; LRR 2; 102..125; LRR 3; 126..150; LRR 4; 151..175; LRR 5; 176..199; LRR 6; 200..223; LRR 7; 224..250; LRR 8; 251..278; LRR 9; 279..308; LRR 10; 309..337; LRR 11; 338..361; LRR 12; 362..388; LRR 13; 389..414; LRR 14; 415..437; LRR 15; 438..457; LRR 16; 458..478; LRR 17; 479..500; LRR 18; 501..524; LRR 19

Domain (FT)

525..579; LRRCT; 635..776; TIR

Region

313..316; Interaction with bacterial lipopeptide

Protein Families

Toll-like receptor family

Sequence Similarities

Belongs to the Toll-like receptor family.

Supporting Publications1

PMID	Title	Abstract
37573658	Exosomes derived from menstrual blood stromal cells ameliorated premature ovarian insufficiency and granulosa cell apoptosis by regulating SMAD3/AKT/MDM2/P53 pathway via delivery of thrombospondin-1.	No abstract available