Protein detail
NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Entry name NHRF2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Protein Class
Predicted intracellular proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Synonym
E3KARPNHERF-2SIP-1TKA-1
Gene Description
SLC9A3 regulator 2
Chromosome
16
Position
2025356-2039026
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificpDCs
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0008013 beta-catenin binding
- GO:0019902 phosphatase binding
- GO:0031799 type 2 metabotropic glutamate receptor binding
- GO:0031800 type 3 metabotropic glutamate receptor binding
- GO:0042802 identical protein binding
- GO:0043495 protein-membrane adaptor activity
- GO:0045296 cadherin binding
Biological Process
Canonical Pathways
- M201 Pid erbb network pathway
- M251 Pid syndecan 3 pathway
- M184 Pid ecadherin keratinocyte pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ARAF | P10398 | NHRF2 | Q15599 | Yes | Yes | No | iPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:26251448SIGNOR:26310448PhosphoSite:26310448 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| LPA(2)-NHERF2-PLC-beta3 complex | LPAR2NHERF2PLCB3 | Q01970Q15599Q9HBW0 | 0:0:0 | CORUM | CORUM:6250 | 15143197 |
| LPAR2-TRIP6-NHERF2 complexLPA stimulated | LPAR2NHERF2TRIP6 | Q15599Q15654Q9HBW0 | 0:0:0 | CORUM | CORUM:6794 | 19293149 |
| NHERF2NPC2NUDT19NUSAP1 | A8MXV4P61916Q15599Q9BXS6 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_309 | ||
| LGALS9LGALS9BNHERF2PBK | O00182Q15599Q3B8N2Q96KB5 | 0:0:0:0 | hu.MAP | |||
| HPDLLSM12NHERF2NUSAP1TACO1TST | Q15599Q16762Q3MHD2Q96IR7Q9BSH4Q9BXS6 | 0:0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_524 |
Sequence, Structure & Domains
Sequences
Length
337
Mass
37,414
Sequence
MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15599-1; Sequence=Displayed; Name=2; IsoId=Q15599-2; Sequence=VSP_009378; Name=3; IsoId=Q15599-3; Sequence=VSP_046849, VSP_046850
Alternative Sequence
1..27; MAAPEPLRPRLCRLVRGEQGYGFHLHG -> MARSGSATPPARAPGAPPRSPPQRLVQ (in isoform 3); 28..138; Missing (in isoform 3); 286..296; Missing (in isoform 2)
3D Structural Models
Helix
44..47; 69..78; 184..188; 209..216; 327..336
Beta Strand
10..15; 23..27; 34..39; 55..59; 82..88; 150..155; 163..167; 169..179; 195..199; 219..228
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
134..144; Basic and acidic residues; 255..275; Polar residues; 327..337; Basic and acidic residues
Domain (FT)
11..90; PDZ 1; 150..230; PDZ 2
Region
107..144; Disordered; 240..337; Disordered
Clinical Relevance
Interaction Protein
ENSG00000001626ENSG00000006740ENSG00000018408ENSG00000064547ENSG00000092820ENSG00000128567ENSG00000129675ENSG00000130402ENSG00000137693ENSG00000167977ENSG00000171862ENSG00000184304
Interaction Count
12
Interaction Dataset
intact_biogridintact_biogrid_opencell