Protein detail

LT4R1

Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7)

Protein symbol LT4R1	UniProt ID Q15722	EVMP score 0.25
Frequency 1	Transmembrane count 7	Protein classification Essential proteinsG-protein coupled receptorsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Leukotriene B4 receptor 1 (LTB4-R 1) (LTB4-R1) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) (P2Y purinoceptor 7) (P2Y7)

Protein Class

Essential proteinsG-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function

G-protein coupled receptors:Adenosine and adenine nucleotide receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

20..42; Helical; Name=1; 55..75; Helical; Name=2; 92..113; Helical; Name=3; 139..159; Helical; Name=4; 179..199; Helical; Name=5; 222..242; Helical; Name=6; 269..289; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000213903

Entrez Gene Symbol

LTB4R

Gene Synonym

BLTRCMKRL1GPR16LTB4R1P2RY7P2Y7

Gene Description

Leukotriene B4 receptor

Chromosome

Position

24311450-24318036

Frequency

EVMP Score

0.25

Fluorescence & Localization

Function & Pathway

Protein Function

G-protein coupled receptors:Adenosine and adenine nucleotide receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

GO:0005886 plasma membrane

Molecular Function

Biological Process

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Reactome

Mediation Categories

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
LTB4R	GRK6	P43250	T	308	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	HPRD:20058876 SIGNOR:12077128 HPRD:12077128 KEA:12077128 phosphoELM:12077128 ProtMapper:12077128
LTB4R	GRK6	P43250	S	310	phosphorylation	PhosphoNetworks
LTB4R	CSNK2A2	P19784	T	308	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

42 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GRK6	P43250	LT4R1	Q15722	Yes	No	Yes	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phos	PhosphoSite:12077128 HPRD-phos:20058876 PhosphoSite:30131369 HPRD-phos:12077128 PhosphoSite:22707565 ProtMapper:20058876 SIGNOR:12077128 HPRD:12077128 KEA:12077128 phosphoELM:12077128 ProtMapper:12077128
LT4R1	Q15722	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LT4R1	Q15722	GNA12	Q03113	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LT4R1	Q15722	GNAI1	P63096	Yes	Yes	No	HINTSIGNOR	SIGNOR:31160049 HINT:35241677
LT4R1	Q15722	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
LT4R1	Q15722	GNA14	O95837	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Small R sequencing (Illumi HiSeq 2000 (Solexa)Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

352

Mass

37,557

Sequence

MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN

3D Structural Models

Helix

14..44; 52..68; 71..80; 86..120; 122..128; 131..148; 152..155; 175..189; 191..208; 221..249; 260..277; 280..292; 294..296; 298..305

Beta Strand

156..160; 166..170; 257..259; 307..309

3D Structure

Electron microscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

310..326; Polar residues; 338..352; Polar residues

Region

310..352; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Related Diseases

Allergic/hypersensitivity disorder Asthma Cystic fibrosis Human immunodeficiency virus disease Indeterminate colitis Low bone mass disorder Pancreatic cancer Postoperative inflammation Prostate cancer Psoriasis Pulmonary disease Renal cell carcinoma Rheumatoid arthritis

Biomarker

Terminated; Discontinued in Phase 2; Phase 2; Discontinued in Phase 1; Phase 1

Drugs

AMELUBANT TELOTRISTAT ETHYL 6-FLUOROTRYPTOPHAN CP-195543 LP533401 NOMACOPAN TPT-004 RODATRISTAT ETALOCIB RECOMBINANT CYTOKINE DEXFENFLURAMINE COMPOUND 23A [PMID: 33417443]LTB4 NULL BIOMED 101 FENCLONINE &ALPHA -PROPYLDOPACETAMIDE

Antibody

HPA003873