Protein detail
CD226
CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226)
Protein symbol CD226 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226)
Protein Class
CD markersHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Endocrine and metabolic diseases:Diabetes
Transmembrane
255..275; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
DNAM-1DNAM1PTA1TLiSA1
Gene Description
CD226 molecule
Chromosome
18
Position
69831158-69961803
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Endocrine and metabolic diseases:Diabetes
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CD226 | PRKCA | P17252 | S | 329 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapper | KEA:9712030phosphoELM:9712030 |
| CD226 | FYN | P06241 | Y | 322 | phosphorylation | REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:21750737 |
Ligand-Receptor Signaling
48 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
Page 5 of 5Previous
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NECT2 | Q92692 | CD226 | Q15762 | Yes | Yes | No | CellChatDBCellPhoneDBUniProt_LRdbICELLNETSIGNORconnectomeDB2020HPRDHINTBaccin2019Lit-BM-17WangLRdb | HPRD:15536144Lit-BM-17:12913096connectomeDB2020:15607800HINT:21982860ICELLNET:27192565HINT:12913096SIGNOR:15039383Lit-BM-17:21982860HPRD:12913096 |
| PVR | P15151 | CD226 | Q15762 | Yes | Yes | No | CellChatDBSparser_ProtMapperCellPhoneDBUniProt_LRdbICELLNETSIGNORProtMapperconnectomeDB2020HPRDHINTWojtowicz2020IntActLit-BM-17WangLRdb | Lit-BM-17:12913096ProtMapper:33670993ICELLNET:15034010HINT:30591568HINT:21982860IntAct:21982860HINT:12913096connectomeDB2020:15607800IntAct:30591568SIGNOR:30591568HINT:31253644Lit-BM-17:21982860HPRD:12913096 |
| FYN | P06241 | CD226 | Q15762 | Yes | No | No | Sparser_ProtMapperiPTMnetPhosphoPointProtMapperHPRDSPIKE_LCREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:32265229ProtMapper:33670993HPRD:10591186PhosphoSite:10591186PhosphoSite:15684041ProtMapper:32774149ProtMapper:21750737SPIKE_LC:16713569PhosphoSite:12847109 |
| KPCA | P17252 | CD226 | Q15762 | Yes | No | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:9712030KEA:9712030phosphoELM:9712030iPTMnet:9712030 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31414377 |
Sequence, Structure & Domains
Sequences
Length
336
Mass
38,614
Sequence
MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQKAPNNYRSPISTSQPTNQSMDDTREDIYVNYPTFSRRPKTRV
3D Structural Models
Turn
65..67; 76..78; 127..129; 130..133; 200..205
Helix
73..75; 86..88; 100..102; 214..216
Beta Strand
23..28; 43..52; 54..56; 58..64; 68..71; 93..97; 104..113; 116..125; 139..142; 148..151; 160..168; 173..184; 191..193; 206..209; 218..229; 232..240
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
297..314; Polar residues
Domain (FT)
19..126; Ig-like C2-type 1; 135..239; Ig-like C2-type 2
Region
297..316; Disordered