Protein detail
SCN9A
Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)
Entry name SCN9A | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 24 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPredicted membrane proteinsTransportersVoltage-gated ion channels
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Voltage-gated ion channels:Voltage-Gated Sodium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
126..145; Helical; Name=S1 of repeat I; 151..172; Helical; Name=S2 of repeat I; 186..204; Helical; Name=S3 of repeat I; 211..227; Helical; Name=S4 of repeat I; 242..267; Helical; Name=S5 of repeat I; 377..402; Helical; Name=S6 of repeat I; 746..762; Helical; Name=S1 of repeat II; 772..796; Helical; Name=S2 of repeat II; 806..822; Helical; Name=S3 of repeat II; 832..848; Helical; Name=S4 of repeat II; 866..888; Helical; Name=S5 of repeat II; 941..967; Helical; Name=S6 of repeat II; 1188..1212; Helical; Name=S1 of repeat III; 1225..1250; Helical; Name=S2 of repeat III; 1253..1278; Helical; Name=S3 of repeat III; 1288..1304; Helical; Name=S4 of repeat III; 1318..1342; Helical; Name=S5 of repeat III; 1432..1457; Helical; Name=S6 of repeat III; 1515..1534; Helical; Name=S1 of repeat IV; 1546..1567; Helical; Name=S2 of repeat IV; 1577..1598; Helical; Name=S3 of repeat IV; 1608..1627; Helical; Name=S4 of repeat IV; 1641..1663; Helical; Name=S5 of repeat IV; 1734..1759; Helical; Name=S6 of repeat IV
Transmembrane Count
24
Ensembl
Entrez Gene Symbol
Gene Synonym
ETHANav1.7NE-NANENAPN1
Gene Description
Sodium voltage-gated channel alpha subunit 9
Chromosome
2
Position
166195185-166376001
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificadrenal glandBrain Regional Specificbasal gangliaCell SpecificBrain excitatory neuronsSingle-Nuclei Brain Specificmedium spiny neuron
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Voltage-gated ion channels:Voltage-Gated Sodium Channels
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| channels | transporter | Surfaceome | No | Yes | No | No | No |
| sodiumchannels | transporter | Surfaceome | No | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| voltage_gated_sodium | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | HGNC | No | Yes | No | No | No |
| voltage_gated | ion_channel | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FGF11 | Q92914 | SCN9A | Q15858 | Yes | No | Yes | SIGNOR | SIGNOR:20679355 |
| FYN | P06241 | SCN9A | Q15858 | Yes | Yes | No | PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:29790812SIGNOR:29790812 |
| NED4L | Q96PU5 | SCN9A | Q15858 | Yes | No | Yes | SIGNOR | SIGNOR:23778145 |
| FGF14 | Q92915 | SCN9A | Q15858 | Yes | No | Yes | SIGNOR | SIGNOR:20679355 |
| FGF12 | P61328 | SCN9A | Q15858 | Yes | No | Yes | SIGNOR | SIGNOR:20679355 |
| FGF13 | Q92913 | SCN9A | Q15858 | Yes | No | Yes | SIGNOR | SIGNOR:20679355 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMicrofluidics-Based Methods | Mass spectrometry | 22 | 39290459233764853150850034071777405459633944354437702715327954143038291738731868268019193007131832927759376863664120109030760538369823124031161640091455381366013861251541315767 |
Sequence, Structure & Domains
Sequences
Length
1,988
Mass
226,372
Sequence
MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEVIIDKATSDDSGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q15858-1; Sequence=Displayed; Name=2; IsoId=Q15858-2; Sequence=VSP_012028; Name=3; IsoId=Q15858-3; Sequence=VSP_012029; Name=4; IsoId=Q15858-4; Sequence=VSP_012028, VSP_012029
Alternative Sequence
200..229; YLTEFVNLGNVSALRTFRVLRALKTISVIP -> YVTEFVDLGNVSALRTFRVLRALKTISVIP (in isoform 2 and isoform 4); 648..658; Missing (in isoform 3 and isoform 4)
3D Structural Models
Turn
51..53; 68..70; 93..95; 106..108; 300..302; 337..341; 389..391; 743..745; 831..833; 863..866; 1344..1347; 1353..1356; 1427..1430; 1467..1469; 1600..1602; 1696..1699; 1712..1714; 1787..1789; 1806..1808; 1811..1813; 1832..1834
Helix
9..11; 17..33; 61..63; 80..84; 114..123; 126..143; 150..152; 153..174; 183..185; 189..205; 210..221; 223..227; 231..244; 246..267; 270..272; 286..291; 296..299; 347..359; 363..374; 376..378; 379..388; 392..434; 729..740; 746..761; 768..772; 800..803; 807..824; 828..830; 834..846; 852..862; 867..894; 896..899; 913..925; 929..939; 941..972; 973..976; 987..1013; 1176..1189; 1192..1209; 1216..1218; 1220..1254; 1257..1277; 1284..1290; 1291..1299; 1300..1303; 1305..1343; 1367..1376; 1392..1403; 1408..1417; 1431..1433; 1434..1444; 1446..1466; 1476..1488; 1503..1512; 1515..1534; 1541..1568; 1570..1575; 1577..1599; 1606..1612; 1613..1616; 1617..1621; 1623..1626; 1631..1639; 1641..1665; 1684..1695; 1700..1707; 1733..1767; 1776..1786; 1799..1805; 1820..1825; 1838..1850; 1855..1870; 1874..1876; 1883..1890
Beta Strand
54..58; 71..73; 85..91; 96..101; 111..113; 176..182; 186..188; 228..230; 273..278; 281..283; 317..321; 328..332; 344..346; 765..767; 825..827; 901..903; 910..912; 981..984; 1278..1280; 1348..1352; 1361..1364; 1378..1384; 1386..1388; 1389..1391; 1421..1423; 1472..1474; 1628..1630; 1666..1669; 1672..1674; 1677..1683; 1722..1724; 1795..1798; 1829..1831; 1835..1837; 1879..1882
3D Structure
Electron microscopy (39); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
26..39; Basic and acidic residues; 461..471; Low complexity; 474..486; Basic residues; 489..510; Basic and acidic residues; 573..585; Basic and acidic residues; 1120..1131; Polar residues; 1137..1148; Acidic residues; 1948..1961; Low complexity; 1962..1988; Basic and acidic residues
Repeat
112..410; I; 726..989; II; 1180..1488; III; 1497..1795; IV
Domain (CC)
The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
Domain (FT)
1889..1918; IQ
Region
26..55; Disordered; 461..543; Disordered; 565..611; Disordered; 1102..1148; Disordered; 1934..1988; Disordered
Protein Families
- Sodium channel (TC 1.A.1.10) family
- Nav1.7/SCN9A subfamily
Sequence Similarities
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily.
Clinical Relevance
Disease Involvement
Disease variantEpilepsyFDA approved drug targets
Related Diseases
Biomarker
Discontinued in Phase 2; Phase 2; Phase 1
Drug Targets
FDA approved drug targets
Drugs
QUINIDINE SULFATETETRACAINETOCAINIDE HYDROCHLORIDENULLMORICIZINE HYDROCHLORIDEAM-6120PROPARACAINE HYDROCHLORIDEFUNAPIDEABBV-318CHLOROPROCAINENERISPIRDINELIDOCAINELACOSAMIDEMEPHENYTOINPROPOFOLDRONEDARONE HYDROCHLORIDEETIDOCAINE HYDROCHLORIDERUFINAMIDEPROPAFENONE HYDROCHLORIDEINDECAINIDE HYDROCHLORIDEESLICARBAZEPINE ACETATEDSP-2230ETHOTOINZONISAMIDEEVENAMIDECENOBAMATESAFINAMIDEPROCAINE HYDROCHLORIDERALFINAMIDEHEXYLCAINE HYDROCHLORIDEDISOPYRAMIDE PHOSPHATEMEPIVACAINE HYDROCHLORIDEPROPOXYCAINE HYDROCHLORIDEESLICARBAZEPINELIDOCAINE HYDROCHLORIDETETRODOTOXINPRIMIDONEVIXOTRIGINEXEN907QUINIDINE GLUCONATECD2+SAXITOXINCOCAINE HYDROCHLORIDEPRILOCAINERG7893ORPHENADRINE CITRATEDICHLOROBENZYL ALCOHOLRANOLAZINEORPHENADRINE HYDROCHLORIDEPRILOCAINE HYDROCHLORIDERG6029PF‐06526290PROCAINAMIDE HYDROCHLORIDEIRAMPANELPHENAZOPYRIDINE HYDROCHLORIDERILUZOLETOPIRAMATEMERETHOXYLLINE PROCAINEDYCLONINE HYDROCHLORIDEPF-05089771QUINIDINE POLYGALACTURONATEBATRACHOTOXINPYRROLOPYRIMIDINE 48 [PMID: 22318156]PF-05241328AZD3161ROPIVACAINE HYDROCHLORIDEMEXILETINE HYDROCHLORIDEDS-1971APHENYTOIN SODIUMARTICAINE HYDROCHLORIDEENCAINIDE HYDROCHLORIDEXEN403PHENACEMIDECARBAMAZEPINENKTR-171OXCARBAZEPINEBENOXINATE HYDROCHLORIDEN-ME-AMINOPYRIMIDINONE 9VERATRIDINEGNE-616FOSPHENYTOINLAMOTRIGINEGNE-131